Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives [0.03%]
钙信号通路在癌症进展中的作用：扩展维度和视角
Mélanie Robitaille,Gregory R Monteith
Mélanie Robitaille
Calcium signaling is a key controller of numerous cellular events and is intricately linked to many processes that are critical pathways in cancer progression. This review revisits the calcium signaling toolkit in cancer, with a focus on ca...
Mendel's Pea Genes [0.03%]
孟德尔的豌豆基因
Julie M I Hofer,Noel Ellis
Julie M I Hofer
Mendel conducted his studies on the transmission of genetic elements from one generation to the next using pea varieties commercially available at that time. He presented segregation data for seven character differences in detail. The molec...
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics [0.03%]
人类端粒酶的调控：从分子作用到群体遗传学
Annika Martin,Dirk Hockemeyer
Annika Martin
Human telomeres play critical roles in protecting chromosome ends and preserving genomic integrity. Telomerase, essential for maintaining telomere length and cellular replicative capacity, is only expressed in a small subset of human cells:...
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning [0.03%]
单细胞迁移的现代建模方法：从膜张力和电压导向性运动到机器学习
Wenzheng Shi,Alex Mogilner
Wenzheng Shi
Cell migration phenomenon has inspired and benefited from computational modeling for decades. Here, we review recent applications of traditional bottom-up modeling to three aspects of cell migration: the role of membrane tension (MT) in org...
How Shelterin Orchestrates the Replication and Protection of Telomeres [0.03%]
shelterin蛋白如何调控端粒的复制与保护
Titia de Lange
Titia de Lange
Efforts to determine how telomeres solve the end-protection problem led to the discovery of shelterin, a conserved six-subunit protein complex that specifically binds to the long arrays of telomeric TTAGGG repeats at vertebrate chromosome e...
Jozef Nosek,Ľubomír Tomáška
Jozef Nosek
Mitochondria are the masters of evolutionary tinkering, which can be exemplified by both the remarkable variability of the mitochondrial genome architectures and numerous noncanonical features involved in the mitochondrial gene expression. ...
Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development [0.03%]
邻近细胞作为引导发育过程中集体细胞迁移的活底物
Hoang Anh Le,Roberto Mayor
Hoang Anh Le
As cells migrate inside the body, they encounter various biochemical and physical cues that provide them with directional guidance. In the past 20 years or so, there has been a significant shift in the effort to understand how physical fact...
Epigenetics Beyond the Cell: Supracellular Organization of Fate and Form in Morphogenesis [0.03%]
细胞外表观遗传学：形态发生中超细胞的命运和形态组织
Rubens Sautchuk Jr,Sichen Yang,Amy Shyer et al.
Rubens Sautchuk Jr et al.
How biological systems obtain their shape and structure is a fundamental question with many practical implications. Like much of biology, over the last several decades, tissue and organ morphogenesis has focused on uncovering regulatory mec...
Peter K Koo,Christian Dallago,Ananthan Nambiar et al.
Peter K Koo et al.
Recent years have seen significant breakthroughs at the intersection of machine learning and protein science. Tools such as AlphaFold have revolutionized protein structure prediction. They are also enabling variant effect prediction and fun...
Justas Dauparas
Justas Dauparas
A protein is defined by its amino acid sequence. This sequence and environmental factors shape a protein's 3D structural landscape, which is crucial for the protein's function and activity. Protein design aims to develop novel protein seque...