William Castle's Guinea Pigs and the Spread of Mendelian Teaching [0.03%]
威廉·Castle的实验小鼠及其对孟德尔教学法的传播的影响
Amir Teicher
Amir Teicher
One of the prime examples of the applicability of Mendel's laws to the animal world involves the characteristics of guinea pig coat color. The paper retraces the history of an especially illustrious example of Mendelian mechanisms in guinea...
Illuminating Mammalian Cell Migration in Native Tissues at Subcellular and Molecular Resolution [0.03%]
在亚细胞和分子水平上解析天然组织中的哺乳动物细胞迁移
Bhagawat C Subramanian,Marco Heydecker,Yeap Ng et al.
Bhagawat C Subramanian et al.
Although cell migration has been extensively investigated using in vitro model systems, the mechanisms underlying mammalian cell migration in native tissue environments remain underexplored. Moreover, efforts to directly manipulate and visu...
Collective Cell Migration Strategies: Patterning, Motility, and Directionality of the Posterior Lateral Line Primordium in Zebrafish [0.03%]
斑马鱼后侧线原基的图案化、运动和定向性及其集体细胞迁移机制
Alex V Nechiporuk,Holger Knaut
Alex V Nechiporuk
During development and homeostasis, tissues move and rearrange to form organs, seal wounds, or-in the case of cancer-spread in the body. To accomplish this, cells in tissues need to communicate with each other, generate force to push themse...
From Signals to Protrusions: Modeling Excitable Systems in Cell Migration [0.03%]
从信号到突起——细胞迁移中的可激活性系统的模型研究
Pablo A Iglesias,Parijat Banerjee
Pablo A Iglesias
Cell migration is a fundamental biological process critical for development, immune response, and wound healing, but its dysregulation contributes to pathological conditions such as cancer metastasis. Recent research has demonstrated that m...
Katherine M Young,Santiago Lopez,Keefer Boone et al.
Katherine M Young et al.
Cell migration is greatly affected by both the physical properties of the motile cell itself and the environment through which the cell is moving. In addition to studying cellular and extracellular mechanical properties in the context of ce...
Arkarup Banerjee,Steven M Phelps,Justus M Kebschull
Arkarup Banerjee
This perspective advocates for "evolutionary systems neuroscience" as a framework combining evolutionary biology with neural circuit analysis. Evolution creates natural circuit modifications that preserve essential functions while enabling ...
Jonathan H Schrope,Tanner F Robertson,Milka Sarris et al.
Jonathan H Schrope et al.
Directed leukocyte motility is essential for immunity and host defense. Dysregulated leukocyte migration is implicated in clinical immunodeficiency and hyperinflammatory conditions. Leukocytes sense both chemical and physical cues within th...
Kenneth C Keiler,Akanksha Varshney,Christine M Dunham
Kenneth C Keiler
trans-Translation is a recoding event in which a translating ribosome switches from the engaged messenger RNA (mRNA) to a specialized reading frame within transfer-messenger RNA (tmRNA) without releasing the nascent polypeptide, producing a...
Lucia Barazzuol,Marisa Brini,Tito Calì
Lucia Barazzuol
The calcium ion (Ca2+) is a pivotal second messenger orchestrating diverse cellular functions, including metabolism, signaling, and apoptosis. Membrane contact sites (MCSs) are critical hubs for Ca2+ exchange, enabling rapid and localized s...
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications [0.03%]
钙信号和代谢重编程在癌症中的作用机制及治疗意义
Evan Courmont,Anna Rita Cantelmo
Evan Courmont
Calcium is essential for cellular homeostasis, orchestrating a vast array of physiological processes through tightly regulated storage, flux, and signaling pathways. Dysregulation of calcium homeostasis disrupts these finely tuned processes...