Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments [0.03%]
软物质物理与细胞生物学的交叉：三维环境中集体细胞迁移的转变
Mirjam M Zegers,Pablo Gottheil,Josef Käs et al.
Mirjam M Zegers et al.
Plasticity of cell migration is a hallmark of cell movement during morphogenesis, tissue repair, and cancer metastasis. Interconversions of migration modes are tissue context-dependent and range from (1) collective migration of cohesive cel...
Traveling in a Pack: The Border Cells' Collective Journey Guided by Landscapes and Chemical Cues [0.03%]
群策群力：边境细胞在景观和化学信号引导下的集体旅程
Alexander George,Michelle Starz-Gaiano
Alexander George
Many cell types migrate collectively, a process critical for animal development and co-opted in some medical disorders. Thus, uncovering the molecular regulation of collective cell migration is of broad interest, yet this process remains un...
Laura C Andreae,Justus M Kebschull,Anthony M Zador
Laura C Andreae
The collection of articles on the theme Evolution and Development of Neural Circuits explores how brains are built, diversified, and adapted in a variety of species, integrating perspectives from evolutionary biology, developmental neurosci...
Camille Rabesahala de Meritens,Nicolas Demaurex
Camille Rabesahala de Meritens
Neutrophils are highly motile white blood cells that protect our body against bacterial and fungal infections. Local and global cytosolic Ca2+ elevations enhance the ability of neutrophils to phagocytose and kill microbes, but how Ca2+ sign...
Modulation of Inositol 1,4,5-Trisphosphate Receptors by Their Primary Physiological Ligands, IP3, Ca2+, and ATP [0.03%]
肌醇 1,4,5-三磷酸受体被其主要生理配基肌醇 1,4,5-三磷酸、Ca2+和ATP调节的作用机制
Vikas Arige,Xiaoxuan Lin,David M MacLean et al.
Vikas Arige et al.
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are ubiquitously expressed intracellular calcium (Ca2+) release channels predominantly localized to the endoplasmic reticulum. There are three IP3R subtypes, which assemble as homo-/heter...
Tatsuki Nonomura,Xiaoxuan Liu,Megan Chiu et al.
Tatsuki Nonomura et al.
Calcium ions (Ca2+) are essential second messengers intimately implicated in a variety of biological processes, ranging from short-term events such as muscle contraction to long-term effects like gene expression. Dysregulated Ca2+ signaling...
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca2+- and Membrane-Binding Proteins [0.03%]
黏附于膜：钙离子和膜结合蛋白的结构、功能及细胞作用力： annexin 家族综述
Carsten Alexander Raabe,Volker Gerke,Ursula Rescher
Carsten Alexander Raabe
Intracellular calcium (Ca2+) signaling is shaped by the coordinated action of pumps, channels, transporters, and Ca2+-binding proteins including the cytosolic annexins, which decode changes in cellular Ca2+ levels and are crucial components...
Telomerase RNA Shapes the Evolutionary Diversity of Telomerase Ribonucleoproteins (RNPs) [0.03%]
端粒酶RNA塑造了端粒酶核糖核蛋白(RNP)的进化多样性
Julian J-L Chen,Raymund J Wellinger
Julian J-L Chen
Telomerase emerged in early eukaryotes as a highly specialized reverse transcriptase for maintaining chromosome integrity. The telomerase enzyme contains an integral RNA, providing the template for DNA repeat synthesis. This central telomer...
Panagiotis Poulis,Marina V Rodnina
Panagiotis Poulis
Ribosomal frameshifting is a recoding mechanism that allows the ribosome to alter its reading frame during translation, often in response to specific messenger RNA (mRNA) elements or cellular conditions. While essential for the life cycle o...
Guiding Cell Migration with Electric Fields: Mechanisms and Applications of Galvanotaxis [0.03%]
电场引导细胞迁移：伽伐尼趋性机制与应用
Min Zhao,Yan Zhang,Kan Zhu et al.
Min Zhao et al.
Electric field-guided cell migration, known as galvanotaxis or electrotaxis, has garnered great interest as an engineering manipulation but has not been widely considered physiologically relevant. Here we provide experimental evidence provi...