Ivan Sorokin,Andrei A Korostelev
Ivan Sorokin
Ribosomes decode 3-nucleotide codons and move in 1-codon increments to maintain the messenger RNA (mRNA) frame thereby accurately producing the encoded protein. In special cases, including viral genomes and regulatory cellular proteins, fra...
Pulling the Back to Steer Cell Migration: Mechanisms of Structural Polarity in Confining Signaling and Protrusion [0.03%]
牵与拉：细胞迁移中限制信号传导和突起的结构极性机制
Bo Gong,Tobias Meyer
Bo Gong
Directed cell migration is a coordinated process mediated by membrane protrusion at the front and contractile retraction at the back. This review compares a local excitation and global inhibition (LEGI) model and an emerging structural pola...
Organized Randomness: How Hierarchical Coupling of an Excitable System and a Bistable Switch Shape Spontaneous Cell Migration [0.03%]
层级耦合的兴奋系统和双稳态开关如何塑造自发细胞迁移中的组织随机性
Masahiro Ueda,Hiroaki Takagi,Satomi Matsuoka
Masahiro Ueda
In various eukaryotic organisms, amoeboid cells undergoing spontaneous migration generate membrane protrusions and establish front-rear polarity in an autonomous manner through signal transduction networks that couple excitable Ras dynamics...
Exploring Self-Organization of Development in the Zebrafish Posterior Lateral Line Primordium with Computer Models [0.03%]
用计算机模型探索斑马鱼后侧线生源细胞团发育的自组织现象
Ajay Chitnis
Ajay Chitnis
The zebrafish posterior lateral line (pLL) primordium migrates under the skin, from the ear to the tip of the tail, periodically forming and depositing neuromasts to spearhead formation of the pLL system. Cellular, molecular, genetic, and p...
Xu Li,Jin Jiang
Xu Li
Originally discovered in Drosophila, the Hippo pathway has emerged as an evolutionarily conserved signaling pathway that controls tissue growth and organ size in species ranging from insects to human. Unsurprisingly, dysregulation of Hippo ...
Many Cells Make Light Work: Self-Generated Gradients Organize Dictyostelium Aggregates and Neutrophil Swarms [0.03%]
多个细胞轻松工作：自生成梯度组织黏菌聚集和中性粒细胞群集
Evelyn Strickland,John F Durel,Allyson E Sgro et al.
Evelyn Strickland et al.
Cells work together to accomplish complex tasks. For example, both neutrophils and Dictyostelid collectives use self-generated multicellular signaling gradients to coordinate aggregation over large areas through local interactions. However,...
Neutrophil Migration: Using All the Tricks of Mesenchymal and Amoeboid Cells to Navigate Many Environments [0.03%]
中性粒细胞迁移：利用间充质样和变形虫样运动方式穿越不同组织屏障 tricks——策略、诡计）
Martina Lerche,Clare M Waterman
Martina Lerche
Humans encounter numerous pathogens every day and therefore rely heavily on the innate immune system that acts as the first line of defense against infectious agents. Neutrophils make up more than half of the circulating leukocytes in human...
Calcium Signaling and Pathogenesis of Neurodegenerative Disorders: Potential Therapeutic Opportunities [0.03%]
钙信号与神经退行性疾病发病机制及潜在治疗机会
Ilya Bezprozvanny
Ilya Bezprozvanny
Alzheimer's disease and other neurodegenerative disorders are major health and economic problems. The main emphasis on treating these disorders has been based on the idea of targeting the amyloid pathway, but these efforts have not yielded ...
Lacy J Barton,Benjamin Lin
Lacy J Barton
Primordial germ cells (PGCs) are embryonic germline precursors of sperm and egg that connect one generation to the next. In many animals, maintaining this intergenerational connection requires long-distance PGC migration across varied tissu...
Leukocyte Chemotaxis and the Elusive Negative Signals that Make It Work [0.03%]
白细胞趋化作用及其难以捉摸的负向信号机制
Kwabena A Badu-Nkansah,Sean R Collins
Kwabena A Badu-Nkansah
The recruitment of leukocytes to target locations in the body is central to both effective immune responses and pathological inflammation. Leukocytes use chemotaxis to find their way, following shallow gradients of attractants through compl...