Meihua Lu,Xuelian Luo
Meihua Lu
The Hippo signaling pathway represents a critical regulatory mechanism governing organ size control, tissue homeostasis, and tumor suppression through modulation of the transcriptional coactivators Yes-associated protein (YAP) and transcrip...
The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis [0.03%]
肠道再生、重编程及肿瘤发生过程中的Hippo信号通路研究进展
Vanessa Man,Jeffrey L Wrana
Vanessa Man
The Hippo signaling pathway, first identified in Drosophila, is a conserved regulator of organ size and tissue homeostasis that balances proliferation and apoptosis. In mammals, its core kinases mammalian Sterile 20-like kinases 1 and 2 (MS...
A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway [0.03%]
遗传学和生物化学的结合揭示了Hippo信号通路的分子架构
Yonggang Zheng,Duojia Pan
Yonggang Zheng
The Hippo signaling pathway is a central regulator of tissue growth in animal development and adult tissue homeostasis, integrating diverse upstream cues to coordinate proliferation and apoptosis. Its discovery stemmed from innovative genet...
Bipin Kumar Tripathi,Kenneth D Irvine
Bipin Kumar Tripathi
Cells are not only biochemical machines but also mechanical entities, which experience physical cues ranging from extracellular matrix (ECM) stiffness to cytoskeletal tension and intercellular adhesion. The Hippo signaling network is a key ...
Robbe Van Gorp,Tihomir Tomašič,Jan B Parys et al.
Robbe Van Gorp et al.
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are an important class of ion channels that mediate calcium (Ca2+) release from the endoplasmic reticulum and other organelles, thereby critically controlling cell function. Dysregulation of th...
Roles and Regulation of the Hippo Signaling Pathway in Mammalian Preimplantation Development [0.03%]
Hippo信号通路在哺乳动物早期胚胎发育中的作用及调控机制研究进展
Hiroshi Sasaki
Hiroshi Sasaki
During preimplantation development, mammalian embryos form blastocysts. Studies in mouse embryos have revealed multiple roles of the Hippo signaling pathway in this process. Among them, the process of TEA domain transcription factor 4 (TEAD...
Recent Developments in (Archaeal) Pyrrolysine and Selenocysteine Specification and Metabolism [0.03%]
近年(selenocysteine和pyrrolysine的合成与代谢的新进展
Nils Peiter,Michael Rother,Joseph A Krzycki
Nils Peiter
Although many naturally occurring modified amino acids have been identified in living organisms, only two, selenocysteine and pyrrolysine, are genetically encoded. Each amino acid is inserted cotranslationally into proteins imparting cataly...
Tian-Xiang Wang,Kun-Liang Guan
Tian-Xiang Wang
The Hippo signaling pathway is an evolutionarily conserved regulatory module that orchestrates a wide range of cellular and physiological processes. It integrates diverse upstream signals and through a sequential kinase cascade to control t...
Corrigendum: Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments [0.03%]
软物质物理与细胞生物学的结合：三维环境中集体细胞迁移的转变（勘误）
Mirjam Zegers,Pablo Gottheil,Josef Käs et al.
Mirjam Zegers et al.
Modeling Collective Cell Migration in a Data-Rich Age: Challenges and Opportunities for Data-Driven Modeling [0.03%]
大数据背景下的集体细胞迁移建模：数据驱动模型的挑战和机遇
Ruth E Baker,Rebecca M Crossley,Carles Falcó et al.
Ruth E Baker et al.
Mathematical modeling has a long history in the context of collective cell migration, with applications throughout development, disease, and regenerative medicine. The aim of modeling in this context is to provide a framework in which to ma...