Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease [0.03%]
围绕施万细胞：健康和疾病下神经肌肉突触单元完整性和功能的守护者
Thomas W Gould,Chien-Ping Ko,Hugh Willison et al.
Thomas W Gould et al.
The neuromuscular junction (NMJ) is a highly reliable synapse to carry the control of the motor commands of the nervous system over the muscles. Its development, organization, and synaptic properties are highly structured and regulated to s...
Glia at Transition Zones [0.03%]
过渡区的胶质细胞
Sarah Kucenas,Pernelle Pulh,Piotr Topilko et al.
Sarah Kucenas et al.
Neural cells are segregated into their distinct central nervous system (CNS) and peripheral nervous system (PNS) domains. However, at specialized regions of the nervous system known as transition zones (TZs), glial cells from both the CNS a...
Modeling the Emergence of Circuit Organization and Function during Development [0.03%]
发育过程中电路的形成及功能建模研究
Shreya Lakhera,Elizabeth Herbert,Julijana Gjorgjieva
Shreya Lakhera
Developing neural circuits show unique patterns of spontaneous activity and structured network connectivity shaped by diverse activity-dependent plasticity mechanisms. Based on extensive experimental work characterizing patterns of spontane...
Carien M Niessen,M Lisa Manning,Sara A Wickström
Carien M Niessen
How tissue architecture and function emerge during development and what facilitates their resilience and homeostatic dynamics during adulthood is a fundamental question in biology. Biological tissue barriers such as the skin epidermis have ...
Stefano Di Talia
Stefano Di Talia
In most species, the earliest stages of embryogenesis are characterized by rapid proliferation, which must be tightly controlled with other cellular processes across the large scale of the embryo. The study of this coordination has recently...
Michael Heinzinger,Burkhard Rost
Michael Heinzinger
From AlphaGO over StableDiffusion to ChatGPT, the recent decade of exponential advances in artificial intelligence (AI) has been altering life. In parallel, advances in computational biology are beginning to decode the language of life: Alp...
Joseph Lipsick
Joseph Lipsick
Transcription factors play crucial roles in cancer, and oncogenic counterparts of cellular transcription factors are present in a number of tumor viruses. It was studies in the early 1980s that first showed tumor viruses could encode nuclea...
Sindy K Y Tang,Wallace F Marshall
Sindy K Y Tang
The ability to regenerate after the loss of a part is a hallmark of living systems and occurs at both the tissue and organ scales, but also within individual cells. Regeneration entails many processes that are physical and mechanical in nat...
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System [0.03%]
中枢神经系统的多发性硬化症及其他获得性脱髓鞘疾病
Michael D Kornberg,Peter A Calabresi
Michael D Kornberg
Acquired demyelinating diseases of the central nervous system (CNS) comprise inflammatory conditions, including multiple sclerosis (MS) and related diseases, as well as noninflammatory conditions caused by toxic, metabolic, infectious, trau...
Misha B Ahrens,Baljit S Khakh,Kira E Poskanzer
Misha B Ahrens
Astrocytes are predominant glial cells that tile the central nervous system and participate in well-established functional and morphological interactions with neurons, blood vessels, and other glia. These ubiquitous cells display rich intra...