Natalia V De Marco García,Gord Fishell
Natalia V De Marco García
A persistent question in neuroscience is how early neuronal subtype identity is established during the development of neuronal circuits. Despite significant progress in the transcriptomic characterization of cortical interneurons, the mecha...
Facioscapulohumeral Dystrophy: Molecular Basis and Therapeutic Opportunities [0.03%]
面肩肱型肌营养不良的分子基础与治疗机会
Tessa Arends,Danielle C Hamm,Silvère van der Maarel et al.
Tessa Arends et al.
Facioscapulohumeral dystrophy (FSHD) is caused by misexpression of the early embryonic transcription factor Double Homeobox Protein 4 (DUX4) in skeletal muscle. DUX4 is normally expressed at the 4-cell stage of the human embryo and initiate...
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks [0.03%]
用循环神经网络模拟正常和异常的电路发展过程
Daniel Zavitz,ShiNung Ching,Geoffrey Goodhill
Daniel Zavitz
Neural development must construct neural circuits that can perform the computations necessary for survival. However, many theoretical models of development do not explicitly address the computational goals of the resulting networks, or comp...
David Rozema,Jean-Léon Maître
David Rozema
The blastocyst forms during the first days of mammalian development. The structure of the blastocyst is conserved among placental mammals and is paramount to the establishment of the first mammalian lineages. The blastocyst is composed of a...
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models [0.03%]
组织活性物质：将力学和信号整合到动力学模型中
David B Brückner,Edouard Hannezo
David B Brückner
The importance of physical forces in the morphogenesis, homeostatic function, and pathological dysfunction of multicellular tissues is being increasingly characterized, both theoretically and experimentally. Analogies between biological sys...
Enteric Glia [0.03%]
肠胶质细胞
Meenakshi Rao,Brian D Gulbransen
Meenakshi Rao
Enteric glia are a unique type of peripheral neuroglia that accompany neurons in the enteric nervous system (ENS) of the digestive tract. The ENS displays integrative neural circuits that are capable of governing moment-to-moment gut functi...
Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance [0.03%]
神经环路的进化：从发育到结构和适应意义
Nikolaos Konstantinides,Claude Desplan
Nikolaos Konstantinides
Neuronal circuits represent the functional units of the brain. Understanding how the circuits are generated to perform computations will help us understand how the brain functions. Nevertheless, neuronal circuits are not engineered, but hav...
The Blood-Brain Barrier: Composition, Properties, and Roles in Brain Health [0.03%]
血脑屏障：组成、性质及其在大脑健康中的作用
Baptiste Lacoste,Alexandre Prat,Moises Freitas-Andrade et al.
Baptiste Lacoste et al.
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier (BBB), which...
Toby G R Andrews,Rashmi Priya
Toby G R Andrews
Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process. Despite the complex and dynamic nature of embryonic development, organs are built with reproducible size, shape, and function, allowing them to support org...
Speciation [0.03%]
物种形成过程
Catherine L Peichel,Daniel I Bolnick,Åke Brännström et al.
Catherine L Peichel et al.
What drives the emergence of new species has fascinated biologists since Darwin. Reproductive barriers to gene flow are a key step in the formation of species, and recent advances have shed new light on how these are established. Genetic, g...