Role of Microglia in Central Nervous System Development and Plasticity [0.03%]
小胶质细胞在中枢神经系统发育和可塑性中的作用
Dorothy P Schafer,Beth Stevens,Mariko L Bennett et al.
Dorothy P Schafer et al.
The nervous system comprises a remarkably diverse and complex network of cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell population...
Gerard Crowley,David Attwell,Hemali Phatnani et al.
Gerard Crowley et al.
It is becoming increasingly clear that the dominant, century-old neurocentric view of neurodegeneration is insufficient to explain why certain neurons degenerate, in particular with aging. Genetic studies in patient populations as well as m...
The Biology of Glia [0.03%]
神经胶质细胞的生物学作用
Beth Stevens,Kelly R Monk,Marc R Freeman
Beth Stevens
Glial cells play critical roles in the nervous system. Rather than being passive support cells as long thought, they are highly active participants. Recent work has shed new light on their many functions, include regulation of synapse forma...
Glial Malignancies [0.03%]
胶质恶性肿瘤
Suzanne J Baker,Hui Zong,Michelle Monje
Suzanne J Baker
Gliomas comprise a diverse spectrum of related tumor subtypes with varying biological and molecular features and clinical outcomes. Advances in detailed genetic and epigenetic characterizations along with an appreciation that subtypes assoc...
Matthew N Rasband,Elior Peles
Matthew N Rasband
Action potential propagation along myelinated axons requires clustered voltage-gated sodium and potassium channels. These channels must be restricted to nodes of Ranvier where the action potential is regenerated. Several mechanisms have evo...
Stefano Schiaffino,Francesco Chemello,Carlo Reggiani
Stefano Schiaffino
The widespread presence of slow-red and fast-white muscles in all vertebrates supports the evolutionary advantage of having two types of motors available for animal movement-a slow economical motor used for most activities, and a fast energ...
Abigail L Mackey
Abigail L Mackey
A critical link in the chain of force transmission from muscle fiber cross-bridge to bone is the interface between muscle and tendon-the myotendinous junction (MTJ). To meet the challenge of connecting these two tissues, the MTJ is speciali...
Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain [0.03%]
中枢神经系统的细胞间液体交换及淋巴清除作用
Leon C D Smyth,Natalie Beschorner,Maiken Nedergaard et al.
Leon C D Smyth et al.
Cerebrospinal fluid (CSF) bathes and cushions the brain; however, it also serves a major role in the clearance of metabolic wastes and in the distribution of glucose, lipids, and amino acids. Unlike every other organ in the body, the brain ...
Autophagy in Skeletal Muscle [0.03%]
自噬与骨骼肌
Anais Franco-Romero,Marco Sandri,Stefano Schiaffino
Anais Franco-Romero
Skeletal muscle fibers possess, like all cells of our body, an evolutionary conserved autophagy machinery, which allows them to segregate unfolded proteins and damaged organelles within autophagosomes, and to induce fusion of autophagosomes...
Anjana Sevagamoorthy,Adeline Vanderver,Jamie L Fraser et al.
Anjana Sevagamoorthy et al.
Inherited white matter disorders (IWMDs) are a phenotypically and genotypically heterogeneous group of disorders affecting the central nervous system (CNS) with or without peripheral neuropathy. They are classified either as leukodystrophie...