The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood-Retinal Barrier Dysfunction [0.03%]
瞬时受体电位通道介导的钙稳态失调在视网膜血管屏障功能障碍中的作用机制研究
Silvia Dragoni,Francesco Moccia,Martin D Bootman
Silvia Dragoni
The inner blood-retinal barrier (iBRB) protects the retinal vasculature from the peripheral circulation. Endothelial cells (ECs) are the core component of the iBRB; their close apposition and linkage via tight junctions limit the passage of...
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres [0.03%]
微同源介导的末端连接在功能失调端粒的作用机制中的作用
David Billing,Agnel Sfeir
David Billing
DNA double-strand break (DSB) repair pathways are crucial for maintaining genome stability and cell viability. However, these pathways can mistakenly recognize chromosome ends as DNA breaks, leading to adverse outcomes such as telomere fusi...
Roderick J O&#x;Sullivan,Roger A Greenberg
Roderick J O&#x;Sullivan
In recent years, significant advances have been made in understanding the intricate details of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a specialized DNA strand break repair mechanism, known as break-...
Teaching School Genetics in the 2020s: Why "Naive" Mendelian Genetics Has to Go [0.03%]
走向遗传教育的2.0版本——是时候告别“幼稚”的孟德尔式教学了
Kostas Kampourakis
Kostas Kampourakis
Whereas Mendelian genetics is an important research program in the life sciences, its school version is problematic. On the one hand, it contains stereotypical representations of Gregor Mendel's work that misrepresent his findings and the h...
Rediscovering and Unrediscovering Gregor Mendel: His Life, Times, and Intellectual Context [0.03%]
重识与再弃识格雷戈尔·门德尔：他的生活时代及智识语境
Sander Gliboff
Sander Gliboff
Two things about Mendel were "rediscovered" in 1900: His famous paper of 1865 and the story of his life and long neglect. Unlike the paper, which anyone could read in its entirety, the story came out only gradually, and many of its elements...
Corrigendum: Modeling the Emergence of Circuit Organization and Function during Development [0.03%]
更正：发育过程中电路结构和功能的出现及建模研究
Shreya Lakhera,Elizabeth Herbert,Julijana Gjorgjieva
Shreya Lakhera
Laura M de Smalen,Christoph Handschin
Laura M de Smalen
Skeletal muscle is one of the tissues with the highest range of variability in metabolic rate, which, to a large extent, is critically dependent on tightly controlled and fine-tuned mitochondrial activity. Besides energy production, other m...
Matishalin Patel,J Arvid Ågren
Matishalin Patel
Biology can be viewed from both an organismal and a genic perspective. A good example is W.D. Hamilton's work on inclusive fitness and kin selection, which puts relatedness at the heart of our understanding of social behavior. Relatedness m...
Silvia Siteni,Anthony Grichuk,Jerry W Shay
Silvia Siteni
While silent in normal differentiated human tissues, telomerase is reactivated in most human cancers. Thus, telomerase is an almost universal oncology target. This update describes preclinical and clinical advancements using a variety of ap...
Legumes and Linguistics: Translating Mendel for the Twenty-First Century [0.03%]
豌豆与语言学——21世纪的孟德尔翻译问题
Kersten Hall,Staffan Müller-Wille
Kersten Hall
Gregor Mendel's seminal publication, "Versuche über Pflanzen-Hybriden" ("Experiments on Plant Hybrids"), which appeared in 1866, is regarded as one of the founding documents of genetics and has therefore been translated several times. In 2...