Caroline L Sokol,Andrew D Luster
Caroline L Sokol
Chemokines are chemotactic cytokines that control the migration and positioning of immune cells in tissues and are critical for the function of the innate immune system. Chemokines control the release of innate immune cells from the bone ma...
Human homosexuality: a paradigmatic arena for sexually antagonistic selection? [0.03%]
人类同性恋：性对抗选择的范例吗？
Andrea Camperio Ciani,Umberto Battaglia,Giovanni Zanzotto
Andrea Camperio Ciani
Sexual conflict likely plays a crucial role in the origin and maintenance of homosexuality in our species. Although environmental factors are known to affect human homosexual (HS) preference, sibling concordances and population patterns rel...
Cell of origin for malignant gliomas and its implication in therapeutic development [0.03%]
胶质瘤起源细胞及其对治疗研发的意义
Hui Zong,Luis F Parada,Suzanne J Baker
Hui Zong
Malignant glioma remains incurable despite tremendous advancement in basic research and clinical practice. The identification of the cell(s) of origin should provide deep insights into leverage points for one to halt disease progression. He...
Hiroyuki Ohkura
Hiroyuki Ohkura
Meiosis is the specialized cell division that generates gametes. In contrast to mitosis, molecular mechanisms and regulation of meiosis are much less understood. Meiosis shares mechanisms and regulation with mitosis in many aspects, but als...
Astrocyte calcium signaling: from observations to functions and the challenges therein [0.03%]
星形胶质细胞钙信号转导：从现象到功能及面临的挑战
Baljit S Khakh,Ken D McCarthy
Baljit S Khakh
We provide an overview of recent progress on the study of astrocyte intracellular Ca(2+) signaling. We consider the methods that have been used to monitor astrocyte Ca(2+) signals, the various types of Ca(2+) signals that have been discover...
Alexis S Chaine,Robert Montgomerie,Bruce E Lyon
Alexis S Chaine
The discovery that extrapair copulation (EPC) and extrapair paternity (EPP) are common in birds led to a paradigm shift in our understanding of the evolution of mating systems. The prevalence of extrapair matings in pair-bonded species sets...
Sexually antagonistic zygotic drive: a new form of genetic conflict between the sex chromosomes [0.03%]
性相反的合子驱动：性别染色体之间遗传冲突的新形式
Urban Friberg,William R Rice
Urban Friberg
Sisters and brothers are completely unrelated with respect to the sex chromosomes they inherit from their heterogametic parent. This has the potential to result in a previously unappreciated form of genetic conflict between the sex chromoso...
Brian S Kim,David Artis
Brian S Kim
Group 2 innate lymphoid cells (ILC2s) play critical roles in anti-helminth immunity, airway epithelial repair, and metabolic homeostasis. Recently, these cells have also emerged as key players in the development of allergic inflammation at ...
Glial development and function in the nervous system of Caenorhabditis elegans [0.03%]
秀丽隐杆线虫神经系统中的胶质细胞发育和功能研究
Shai Shaham
Shai Shaham
The nematode, Caenorhabditis elegans, has served as a fruitful setting for understanding conserved biological processes. The past decade has seen the rise of this model organism as an important tool for uncovering the mysteries of the glial...
The blood-brain barrier [0.03%]
血脑屏障
Richard Daneman,Alexandre Prat
Richard Daneman
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier, ...