In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function [0.03%]
环状结构中的异常DNA结构及其对端粒功能的影响
Elia Zanella,Ylli Doksani
Elia Zanella
Telomeric repeats recruit the shelterin complex to prevent activation of the double-strand break response at chromosome ends. Thousands of TTAGGG repeats are present at each chromosome end to ensure telomere function. This abundance of G-ri...
Patricia L Opresko,Samantha L Sanford,Mariarosaria De Rosa
Patricia L Opresko
Oxidative stress is associated with increasing telomere shortening and telomere dysfunction, as well as with numerous pathologies in humans, including inflammatory diseases and cancer. Critically short and dysfunctional telomeres lose their...
Maintaining Telomeres without Telomerase in Drosophila: Novel Mechanisms and Rapid Evolution to Save a Genus [0.03%]
果蝇保端粒而不依赖端粒酶的新型机制及其在种系保存中的快速进化
Stefano Cacchione,Giovanni Cenci,Anne-Marie Dion-Côté et al.
Stefano Cacchione et al.
Telomere maintenance is crucial for preventing the linear eukaryotic chromosome ends from being mistaken for DNA double-strand breaks, thereby avoiding chromosome fusions and the loss of genetic material. Unlike most eukaryotes that use tel...
Miguel Godinho Ferreira
Miguel Godinho Ferreira
Fish telomere lengths vary significantly across the numerous species, implicating diverse life strategies and environmental adaptations. Zebrafish have telomere dynamics that are comparable to humans and are emerging as a key model in which...
Marta Markiewicz-Potoczny,Eros Lazzerini Denchi
Marta Markiewicz-Potoczny
The natural ends of chromosomes resemble double-strand breaks (DSBs), which would activate the DNA damage response (DDR) pathway without the protection provided by a specialized protein complex called shelterin. Over the past decades, exten...
Life and Death without Telomerase: The Saccharomyces cerevisiae Model [0.03%]
端粒酶存在的酵母细胞生命与死亡：酿酒酵母模型研究
Veronica Martinez-Fernandez,Aurélia Barascu,Maria Teresa Teixeira
Veronica Martinez-Fernandez
Saccharomyces cerevisiae, a model organism in telomere biology, has been instrumental in pioneering a comprehensive understanding of the molecular processes that occur in the absence of telomerase across eukaryotes. This exploration spans i...
Nils Roll-Hansen
Nils Roll-Hansen
This paper argues that the historiography of genetics ∼1900, the formation period of modern science, is too narrow. It lacks attention to plant breeding. Perhaps this omission also narrows the present understanding of fundamental ideas lik...
Samir Okasha
Samir Okasha
It is well-known that the rediscovery of Mendelian genetics at the turn of twentieth century offered Darwin's theory a much-needed lifeline, by showing how Fleeming Jenkins' famous "blending" objection could be rebutted. However, Mendelism ...
Duncan M Baird
Duncan M Baird
Telomere function is critical for genomic stability; in the context of a functional TP53 response, telomere erosion leads to a G1/S cell-cycle arrest and the induction of replicative senescence, a process that is considered to underpin the ...
Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks [0.03%]
四维生物打印：利用活性力学进行活体墨水构建
Honesty Kim,Grace Hu,Austin J Graham et al.
Honesty Kim et al.
Three-dimensional (3D) printing can be beneficial to tissue engineers and the regenerative medicine community because of its potential to rapidly build elaborate 3D structures from cellular and material inks. However, predicting changes to ...