Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output [0.03%]
Yorkshire/ YORKIE 相互作用蛋白：微调 Hippo 信号通路的输出
Alexey Veraksa,Kenneth H Moberg
Alexey Veraksa
In a canonical view of Hippo signaling, the upstream kinases Hippo/MST and Warts (Wts)/large tumor suppressor (LATS) act as an on/off switch that controls phosphorylation and nuclear access of the key pathway effectors, Yorkie (Yki)/Yes-ass...
Transcriptional and Epigenetic Regulation of Cell Fate by YAP and TAZ [0.03%]
YAP和TAZ对细胞命运的转录及表观遗传调控
Ju-Gyeong Kang,Taejun Seol,Younghoon Kim et al.
Ju-Gyeong Kang et al.
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) (YAP/TAZ) are key transcriptional coregulators that govern mammalian cell fate through complex epigenetic mechanisms. As core effectors of the Hippo s...
Chen Weller,Osnat Bartok,Panagiotis Poulis et al.
Chen Weller et al.
Protein synthesis is tightly regulated in cells; however, in cancer, ribosomes deviate from canonical translation, generating altered protein products. These deviations arise from cell-intrinsic alterations, as well as extrinsic pressures w...
Targeting Yes-Associated Protein (YAP)/Transcriptional Coactivators with PDZ-Binding Motif (TAZ)-Transcriptional Enhanced Associate Domain (TEAD) for Cancer and Regenerative Medicine [0.03%]
靶向转录共激活因子Yes相关蛋白/含PDZ结合基序的转录共激活因子与转录增强子关联域用于癌症和再生医学
Ramesh Kumar,Zebin Hong,Sakshibeedu R Bharath et al.
Ramesh Kumar et al.
The evolutionarily conserved Hippo signaling pathway is crucial for regulating organ size, tissue homeostasis, and regeneration. Mammalian Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) and its interac...
Proteomic Analysis of Hippo Pathway Protein-Protein Interactions [0.03%]
Hippo信号通路蛋白质-蛋白质相互作用的蛋白质组分析
Jeongmin An,Wenqi Wang
Jeongmin An
The Hippo pathway is a conserved signaling cascade that regulates development, regeneration, tissue homeostasis, and organ size through a network of protein-protein interactions (PPIs). Since its discovery in Drosophila, PPI studies have si...
Cell Migration [0.03%]
细胞迁移
Michelle Starz-Gaiano,Peter N Devreotes
Michelle Starz-Gaiano
Cell migration is a dynamic, ubiquitous cellular behavior-and understanding it is advancing at an exceptional pace. This Perspectives in Biology volume aims to capture the field's breadth and depth, organizing chapters that span mechanisms ...
The Multifaceted Roles of the Hippo-Yes-Associated Protein (YAP)/Transcriptional Coactivator with a PDZ-Binding Motif Pathway in Regulating the Tumor Microenvironment [0.03%]
Hippo-YAP/TAZ信号通路在调控肿瘤微环境中的多重作用机制
Zihao Sui,Ting Wang,Chunling Yi
Zihao Sui
The Hippo-Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding motif (TAZ) pathway is frequently dysregulated in cancers. Beyond tumor cell-intrinsic functions of this pathway, Hippo-YAP/TAZ signaling exerts profound ...
Evolutionary and Biochemical Perspectives on the Incorporation and Utilization of Selenocysteine [0.03%]
从进化和生化角度论述硒半胱氨酸的引入及应用
Mihajlo Stašuk,Jesse Donovan,Paul R Copeland et al.
Mihajlo Stašuk et al.
Selenocysteine (Sec) incorporation is a uniquely complex and essential form of ribosomal recoding that redefines in-frame UGA codons through an evolutionarily ancient apparatus. Eukaryotic selenoprotein biosynthesis requires a specialized t...
Hilda Delgado de la Herran,Michael Feng,Margarita Chudenkova et al.
Hilda Delgado de la Herran et al.
Mitochondria act as dynamic signaling hubs, constantly adapting to tissue-specific metabolic demands to ensure cell homeostasis. Central to this role is their capacity to take up calcium (Ca2+) into the matrix, a process that regulates ener...
Growth Control and Beyond: Functional Diversity and Regulation of the Hippo Pathway in the Nervous System [0.03%]
生长调控及其他：Hippo信号通路在神经系统中的功能多样性及调节机制研究
Xinwei Cao
Xinwei Cao
The Hippo pathway prevents tissue overgrowth and tumorigenesis in many organs across species. Not surprisingly, this pathway limits the proliferation of progenitor cells in diverse regions of the nervous system, and its dysregulation can le...