A Meta-Analysis of International Flunixin Pharmacokinetics in Horses: Toward Regulatory Harmonization and Individualized Detection Times Using Bayesian Paradigm [0.03%]
基于贝叶斯理论的国际马匹氟尼辛药代动力学的meta分析：走向监管协调与个体化检测时间确定
Taisuke Kuroda,Heather K Knych,Glenys K Noble et al.
Taisuke Kuroda et al.
Flunixin meglumine is widely used to manage pain and inflammation in horses, and its regulation requires robust pharmacokinetic analysis for harmonization. In this study, we conducted a meta-analysis of flunixin disposition using plasma and...
Distinguishing Between Oral and Transdermal Administration Routes of Methyltestosterone Through Human Urine and Dried Blood Spot Analyses for Doping Control Purposes [0.03%]
用于反兴奋剂目的的人尿和干血斑分析区分甲基睾丸酮的口服和透皮给药途径
Masato Okano,Yuma Watanabe,Asami Miyamoto et al.
Masato Okano et al.
Unintentional doping violations have been reported after secondary skin exposure, including partner contact or contact sports. Methyltestosterone (MT), an anabolic androgenic steroid on the World Anti-Doping Agency Prohibited List, is readi...
Olivier Salamin,Joséphine Chappuis,Lasse V Bækken et al.
Olivier Salamin et al.
Erythropoietin receptor agonists (ERAs), including continuous erythropoietin receptor activators (CERAs), are potent blood doping substances used to enhance endurance performance by stimulating erythropoiesis. While traditionally detected t...
Evaluating the Testosterone-to-Luteinizing Hormone Ratio in Male Anti-Doping Serum Samples: Results From a Transdermal Testosterone Administration Trial and Field Collected Samples [0.03%]
基于经皮睾酮给药试验和现场收集样本评估男子反兴奋剂血清样品中的睾酮-黄体生成素比率
Jenna M Goodrum,Vinod S Nair,Andre K Crouch et al.
Jenna M Goodrum et al.
The serum testosterone-to-luteinizing hormone (T/LH) ratio has previously been suggested as a sensitive marker of testosterone use in an anti-doping setting. When measured with an automated immunoassay platform, this ratio represents a quic...
Equine Metabolism of Voxelotor and Its Impact on Hematological Indices: A Doping Control Perspective [0.03%]
伏诺托克在赛马体内的代谢及其对血液学指标的影响——从反兴奋剂控制的角度分析研究
Abdul Khader Karakka Kal,Michael Benedict Subhahar,Moses Philip et al.
Abdul Khader Karakka Kal et al.
Voxelotor, a therapeutic drug for sickle cell disease, has been reported to elevate serum erythropoietin and hemoglobin levels in healthy individuals. Because of its potential to alter blood parameters, the World Anti-Doping Agency (WADA) c...
Kathrine B Faldborg,Jørgen B Hasselstrøm,Thomas Kraemer et al.
Kathrine B Faldborg et al.
Gamma-hydroxybutyric acid (GHB) has been implicated in drug-facilitated sexual assault (DFSA). However, due to its rapid elimination and the challenge of distinguishing exogenous from endogenous levels, GHB is likely to be significantly und...
Prevalence of AAS-Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub-Study of Dual Use of AAS and Narcotics [0.03%]
2014年至2023年瑞典药物滥用实验室中阳性样本的流行率及类固醇和阿片类物质共用亚研究
Kim Petterson Bohlin,Tomas Villén,Oscar Hopcraft et al.
Kim Petterson Bohlin et al.
It is of interest to investigate trends in AAS usage profile. Here we aimed to retrospectively study the prevalence of AAS-positive samples based on 21,172 consecutive analyses from routine AAS testing 2014-2023. Moreover, 310 urine samples...
Identification of Candidate Biomarkers Detected in the Urine of Racehorses After Anabolic Agent Administration: Use of Orthogonal Methods for Structural Elucidation [0.03%]
赛马服用合成代谢药物后尿液中潜在生物标志物的鉴定：运用正交方法进行结构阐明
C Cloteau,V Delcourt,B Loup et al.
C Cloteau et al.
Biomarker identification by mass spectrometry represents a key step in the workflow of nontargeted metabolomic studies. Given the complexity of the data, this step, which must be carried out by a trained specialist, is time-consuming, and t...
Clostebol Metabolism by Different Routes of Administration: Selection of Diagnostic Urinary Markers [0.03%]
不同的给药途径对克鲁特代谢谱的影响及选择诊断标志物
Xavier de la Torre,Cristiana Colamonici,Dayamin Martínez Brito et al.
Xavier de la Torre et al.
The accidental contamination by the use of transdermal applications of clostebol acetate has been proven by the monitoring of its main urinary metabolite 4-chloro-3α-hydroxy-androst-4-en-17-one (M1). This work is aimed at describing closte...
Comparative Evaluation of Smart Sampling for hCG Determination: A New Potential Direction in Protein Biomarker Analysis From Dried Microsamples [0.03%]
智能取样法在人绒毛膜促性腺激素测定中的比较评估——来自干微样本的蛋白质生物标志物分析的新潜在方向
Ago Mrsa,Marijana Matijevic,Yvette Dehnes et al.
Ago Mrsa et al.
Since the early 20th century, sampling biological matrices like blood on paper (dried blood spots [DBS]) has been vital in clinical analysis. While DBS microsampling is convenient for small molecules, extensive sample preparation can make L...