Detection of Nandrolone Decanoate and Its Metabolites in Equine Hair After Intramuscular Administration [0.03%]
马注射癸酸纳布龙后毛发中该药物及其代谢产物的检测
Yat-Ming So,Wai Him Kwok,Stella M S Yuen et al.
Yat-Ming So et al.
This paper describes the detection of nandrolone decanoate and its metabolites in mane hair collected from horses that have been treated with nandrolone decanoate (Deca-Durabolin). The intramuscular administration study of nandrolone decano...
Further Insights Into the Metabolism of LGD-4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake [0.03%]
LGD-4033人体尿液代谢的进一步见解。第二部分：一种新的次要代谢物具有雄激素受体拮抗活性可指示近期摄入该物质
Yiannis S Angelis,Panagiotis Sakellariou,Annekathrin M Keiler et al.
Yiannis S Angelis et al.
Using a targeted metabolic investigation approach, a new, previously undescribed metabolite, which is a pyrrole derivative of LGD-4033, has been detected and coded as M8. This metabolite can be detected in postadministration human urine sam...
Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations [0.03%]
关于二甲双胍在马体内的药代动力学及检测时间的蒙特卡罗模拟研究
Megan E Jacobs,Jeff Blea,Michael Hardy et al.
Megan E Jacobs et al.
The racehorse industry has strict regulations regarding the detection of prohibited substances in horses. Metformin, a diabetes medication, is a prohibited substance that has been reported in post-race blood and urine samples collected from...
PEth Cut-Off Thresholds for Hazardous Alcohol Consumption Based on a Drinking Study [0.03%]
基于饮酒研究的危险饮酒PEth临界值标准
Lisa Walther,Joanna Stenton,Therese Hansson et al.
Lisa Walther et al.
This study aimed to explore how PEth and other commonly used alcohol biomarkers (CDT, AST, ALT, and GGT) respond to regular consumption of what has been generally considered to correspond to low to moderate amounts of alcohol over a 2-week ...
Oxidative Processes to Transform and Degrade Amphetamine-Type Stimulants: Alternatives to Incineration [0.03%]
用于转化和降解安非他命类刺激剂的氧化处理工艺——焚烧之外的选择
Alexandra L Mercieca,Morgan Alonzo,Scott Chadwick et al.
Alexandra L Mercieca et al.
Although incineration is currently the primary method for the disposal of seized illicit drugs, alternative methods for the disposal of illicit drugs may be necessary to provide safer and more accessible alternatives. Chemical oxidation pro...
Identification of Metabolites for the Novel 5α-Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing [0.03%]
新型5α-还原酶抑制剂依普利特体外代谢产物的鉴定及其潜在的兴奋剂检测问题的影响研究
Zhongquan Li,Bing Liu,Yirang Wang et al.
Zhongquan Li et al.
Epristeride, a novel noncompetitive inhibitor of Type II 5α-reductase, has emerged as a potential therapeutic alternative for benign prostatic hyperplasia (BPH). Given that other 5α-reductase inhibitors, such as finasteride and dutasterid...
Clenbuterol, but not Inhaled Formoterol, Upregulates the Sarcomere Stabilizer KLHL41 to a Similar Extent as Resistance Training in Human Skeletal Muscle [0.03%]
克仑特罗而非雾化福莫特罗像抗阻训练一样上调人类骨骼肌中的肌小节稳定因子KLHL41
Morten Hostrup,Lukas Moesgaard,Martin Thomassen et al.
Morten Hostrup et al.
Beta2-adrenergic agonists are widely used for bronchial relief in respiratory conditions such as asthma and exercise-induced bronchoconstriction. However, this drug class has also been shown to have muscle anabolic properties. Kelch-Like Fa...
Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure [0.03%]
氯乙酰苯酮(CN催泪瓦斯在体外能与内源性血浆硫醇形成加合物用作暴露生物标志物的研究价值
Paula Helena Sieber,Dirk Steinritz,Franz Worek et al.
Paula Helena Sieber et al.
As the tear gas of the highest toxicity, 2-chloroacetophenone (CN) poses a potential threat for exposed individuals. Several fatality cases following exposure to CN are documented, but an unambiguous identification of CN exposure is still m...
Patrick B Kyle,Morgan C Bell,Akram Shalaby et al.
Patrick B Kyle et al.
Synthetic products are marketed for specimen substitution and can be difficult to identify because many contain creatinine, urea, and pH buffers designed to meet acceptance criteria of common specimen validity tests. Methods involving DNA a...
Mapping of the Pharmacological Effect of Prohibited Substances and Methods to Athletic Physiological Characteristics [0.03%]
禁用物质和方法的药理作用与运动员生理特征的关联映射
Gregory Hayward,Lorenzo Gaborini,Neil Robinson et al.
Gregory Hayward et al.
This study presents a novel physio-pharmacological framework for assessing the potential performance-enhancing effects of substances and methods included in the 2022 World Anti-Doping Agency (WADA) Prohibited List across 160 Olympic sport d...