Balancing Performance and Interpretability: Selecting Features with Bootstrapped Ridge Regression [0.03%]
基于自助法岭回归的选择性特征以平衡性能和可解释性
Matthew C Lenert,Colin G Walsh
Matthew C Lenert
Informctticists sometimes attempt to predict chronic healthcare events that are not fully understood. The resulting models often incorporate copious numbers of predictors derived across diverse datasets. This approach may yield desirable pe...
Mining clinical big data for drug safety: Detecting inadequate treatment with a DNA sequence alignment algorithm [0.03%]
基于临床大数据的药物安全性数据挖掘研究：运用DNA序列比对算法探测治疗不足现象
Thibault Ledieu,Guillaume Bouzille,Catherine Plaisant et al.
Thibault Ledieu et al.
Health data mining can bring valuable information for drug safety activities. We developed a visual analytics tool to find specific clinical event sequences within the data contained in a clinical data warehouse. To this aim, we adapted the...
Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients [0.03%]
整合型机器学习流水线用于异常生物标志物的富集(i-mAB)：在系统性红斑狼疮患者文献综述中表征分化簇
Trang T Le,Nigel O Blackwood,Jaclyn N Taroni et al.
Trang T Le et al.
Clusters of differentiation (CD) are cell surface biomarkers that denote key biological differences between cell types and disease state. CD-targeting therapeutic monoclonal antibodies (mABs) afford rich trans-disease repositioning opportun...
DrKnow: A Diagnostic Learning Tool with Feedback from Automated Clinical Decision Support [0.03%]
基于自动化临床决策支持的诊断反馈学习工具
Piyapong Khumrin,Anna Ryan,Terry Juddy et al.
Piyapong Khumrin et al.
Providing medical trainees with effective feedback is critical to the successful development of their diagnostic reasoning skills. We present the design of DrKnow, a web-based learning application that utilises a clinical decision support s...
Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures [0.03%]
整合转录组数据识别哮喘相关全局和细胞特异性基因表达特征
Mengyuan Kan,Maya Shumyatcher,Avantika Diwadkar et al.
Mengyuan Kan et al.
Over 140,000 transcriptomic studies performed in healthy and diseased cell and tissue types, at baseline and after exposure to various agents, are available in public repositories. Integrating results of transcriptomic datasets has been an ...
Re-Identification Risk in HIPAA De-Identified Datasets: The MVA Attack [0.03%]
HIPAA去识别数据集中的再识别风险：MVA攻击
Victor Janmey,Peter L Elkin
Victor Janmey
We present a re-identification attack that uses indirect (non-HIPAA) identifiers to target a vulnerable subset of records de-identified to the HIPAA Safe Harbor standard, those involving motor vehicle accidents (MVAs). Documentation of an M...
Using Demographic Factors and Comorbidities to Develop a Predictive Model for ICU Mortality in Patients with Acute Exacerbation COPD [0.03%]
基于人口统计学因素和伴随疾病的ICU急性加重期COPD患者死亡率预测模型的建立
Sukrit S Jain,Indra Neil Sarkar,Paul C Stey et al.
Sukrit S Jain et al.
Recognizing factors associated with mortality in patients admitted to the ICU with acute exacerbation of chronic obstructive pulmonary disease could reduce healthcare costs and improve end-of-life care. Previous studies have identified poss...
Clinical Documentation in Electronic Health Record Systems: Analysis of Similarity in Progress Notes from Consecutive Outpatient Ophthalmology Encounters [0.03%]
电子健康记录系统中的临床文档：门诊连续眼科就诊过程中进展笔记相似性分析
Abigail E Huang,Michelle R Hribar,Isaac H Goldstein et al.
Abigail E Huang et al.
Content importing technology enables duplication of large amounts of clinical text in electronic health record (EHR) progress notes. It can be difficult to find key sections such as Assessment and Plan in the resulting note. To quantify the...
Disease comorbidity-guided drug repositioning: a case study in schizophrenia [0.03%]
基于疾病共病的药物再定位研究——以精神分裂症为例
QuanQiu Wang,Rong Xu
QuanQiu Wang
The key to any computational drug repositioning is the availability of relevant data in machine-understandable format. While large amount of genetic, genomic and chemical data are publicly available, large-scale higher-level disease and dru...
Yu Chen,Kingsley T Abel,Steven C Cramer et al.
Yu Chen et al.
Stroke is a chronic condition and a leading cause of disability. After hospital discharge, patients need to transition into home-based rehabilitation, a long and distressful process. However, they are often ill-prepared to manage recovery a...