miR-494-3p Promotes Erastin-Induced Ferroptosis by Targeting REST to Activate the Interplay between SP1 and ACSL4 in Parkinson's Disease [0.03%]
miR-494-3p通过靶向REST激活SP1和ACSL4之间的相互作用促进尔астин诱导的铁死亡在帕金森病中的作用
Jianjun Ma,Xiaohuan Li,Yongyan Fan et al.
Jianjun Ma et al.
Background: Ferroptosis is a type of iron-dependent programmed cell death. Ferroptosis has been shown to be a significant factor for the pathogenesis of Parkinson's disease (PD). However, the mechanism involved in ferropt...
Comprehensive Network Analysis Reveals the Targets and Potential Multitarget Drugs of Type 2 Diabetes Mellitus [0.03%]
综合网络分析揭示2型糖尿病 mellitus的靶点及潜在的多靶药物
Wan Zhou,Qiang Liu,Wei Wang et al.
Wan Zhou et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disease with increasing prevalence and mortality year by year. The purpose of this study was to explore new therapeutic targets and candidate drugs for multitargets by single-cell RNA expressio...
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial [0.03%]
左卡尼汀治疗急性缺血性脑卒中的临床疗效观察：一项前瞻性随机双盲自身对照研究
Mehrdokht Mazdeh,Parnaz Abolfathi,Maryam Sabetghadam et al.
Mehrdokht Mazdeh et al.
Background: This study was undertaken to evaluate the influence of oral Acetyl-L-carnitine (ALC) in patients with acute ischemic stroke. Methods: ...
Randomized Controlled Trial
Oxidative medicine and cellular longevity. 2022 Jul 29:2022:2493053. DOI:10.1155/2022/2493053 2022
Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 [0.03%]
rutin和quercetin通过调节炎症、氧化应激、凋亡和nrf2对抗wistar大鼠多柔比星肝毒性
Osama M Ahmed,Mohammed H Elkomy,Hanaa I Fahim et al.
Osama M Ahmed et al.
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (...
Hemodynamic and Geometric Risk Factors for In-Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis [0.03%]
颅内动脉粥样硬化性狭窄患者血管内治疗术后再狭窄的血流动力学及解剖因素分析
Xiaowen Song,Hancheng Qiu,Shuo Wang et al.
Xiaowen Song et al.
Methods: Severe ICAS patients managed with percutaneous transluminal angioplasty and stenting (PTAS) were included in the retrospective cohort study and were divided into two groups according to whether ISR occurred at fo...
Liver Regeneration: Changes in Oxidative Stress, Immune System, Cytokines, and Epigenetic Modifications Associated with Aging [0.03%]
衰老相关的肝脏再生：氧化应激、免疫系统、细胞因子和表观遗传修饰的变化
Chaoliang Tang,Hao Chen,Lai Jiang et al.
Chaoliang Tang et al.
The regenerative capacity of the liver decreases with increase in age. In recent years, studies in mice have found that the regenerative capacity of the liver is associated with changes in the immune system of the liver, cytokines in the bo...
A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation [0.03%]
一种LINARIN衍生物通过依赖KDELR的CSPG4活化促进脑血流恢复从而保护小鼠免受缺血诱导的神经元损伤
Cong Xie,Shiqin Yue,Xiangzhu Li et al.
Cong Xie et al.
The cerebral ischemic microvascular response and collateral circulation compensatory capacity are important for the outcome of ischemic stroke. Here, we sought to evaluate the effect of a linarin derivate 4'-benzylapigenin-7-β-rutinoside (...
Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway [0.03%]
多巴胺D2受体通过猫森亭B/线粒体转录因子A/活性氧通路抑制急性胰腺炎中的腺泡细胞坏死性凋亡
Zengkai Wu,Xiao Han,Jingpiao Bao et al.
Zengkai Wu et al.
Acute pancreatitis (AP) is an inflammatory disease that is associated with trypsinogen activation, mitochondrial dysfunction, cell death, and inflammation. Dopamine D2 receptor (DRD2) plays an essential role in alleviating AP, while it is u...
Wumei Pill Ameliorates AOM/DSS-Induced Colitis-Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S-Adenosylhomocysteine Hydrolase- (AHCY-) Mediated Hedgehog Signaling in Mice [0.03%]
五味子 Pill通过调节S-腺苷蛋氨酸脱羧酶介导的Hedgehog信号通路抑制炎症和氧化应激改善AOM/DSS诱导的结肠炎相关结直肠癌
Jue Wang,Kang Ding,Yuhang Wang et al.
Jue Wang et al.
Wumei Pill (WMP) is a traditional Chinese herbal formulation and widely used to treat digestive system diseases in clinical. S-Adenosylhomocysteine hydrolase (AHCY) can catalyze the hydrolysis of S-adenosylhomocysteine to adenosine and homo...
Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases [0.03%]
超越突触分泌：靶向突触和神经递质以治疗神经退行性疾病
Ziqing Wei,Mingze Wei,Xiaoyu Yang et al.
Ziqing Wei et al.
The nervous system is important, because it regulates the physiological function of the body. Neurons are the most basic structural and functional unit of the nervous system. The synapse is an asymmetric structure that is important for neur...