Diagnostic and Therapeutic Roles of Extracellular Vesicles in Aging-Related Diseases [0.03%]
外泌体在衰老相关性疾病中的诊断和治疗作用
Zixuan Sun,Xiaomei Hou,Jiaxin Zhang et al.
Zixuan Sun et al.
Aging shows a decline in overall physical function, and cellular senescence is the powerful catalyst leading to aging. Considering that aging will be accompanied with the emergence of various aging-related diseases, research on new antiagin...
Delicaflavone Represses Lung Cancer Growth by Activating Antitumor Immune Response through N6-Methyladenosine Transferases and Oxidative Stress [0.03%]
N6-甲基腺苷转移酶和氧化应激介导的香豆素delicaflavone通过激活抗肿瘤免疫反应抑制肺癌生长
Xuewen Wang,Dafen Xu,Bing Chen et al.
Xuewen Wang et al.
Our previous studies have shown that delicaflavone (DLL), a biocomponent extracted from Selaginella doederleinii Hieron, has antitumor activity. However, the role of DLL in the antitumor immune response is unknown. In this study, we tested ...
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis [0.03%]
褪黑素通过抑制NRF2/Slc7a11轴介导的铁死亡缓解急性肾损伤
Yue-Bo Huang,Ling Jiang,Xue-Qi Liu et al.
Yue-Bo Huang et al.
Acute kidney injury (AKI) is still a puzzling clinical problem; its pathophysiology is not completely understood. Up to now, an effective treatment for AKI is lacking. Ferroptosis is a novel form of regulated cell death characterized by the...
N1-Methyladenosine-Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Response in Uterine Corpus Endometrial Carcinoma [0.03%]
N1-甲基腺苷相关长链非编码RNA可能是子宫内膜癌预后及免疫反应的潜在生物标志物
Jinhui Liu,Rui Geng,Zihang Zhong et al.
Jinhui Liu et al.
Uterine corpus endometrial carcinoma (UCEC) is a malignant disease that, at present, has no well-characterised prognostic biomarker. In this study, two clusters were identified based on 28 N1-methyladenosine- (m1A-) related long noncoding R...
Systematic Oxidative Stress Indexes Associated with the Prognosis in Patients with T Lymphoblastic Lymphoma/Leukemia [0.03%]
T淋巴母细胞淋巴瘤/白血病患者预后相关氧化应激指数的分析
Liqin Ping,Yan Gao,Yanxia He et al.
Liqin Ping et al.
Background: T lymphoblastic lymphoma/leukemia (T-LBL/ALL) is an aggressive malignant tumor with 5-year overall survival (OS) rate reached 80% after high-dose chemotherapy. Due to the relatively low incidence of T-LBL/ALL,...
Apigenin Induced Apoptosis by Downregulating Sulfiredoxin Expression in Cutaneous Squamous Cell Carcinoma [0.03%]
染料木素通过下调硫铁蛋白表达诱导皮肤鳞状细胞癌凋亡
Wenhua Wang,Xin Liu,Zhibao Zhang et al.
Wenhua Wang et al.
Cutaneous squamous cell carcinoma (cSCC) is the second carcinoma in nonmelanoma skin cancer (NMSC). Sulfiredoxin (Srx) is an antioxidant protein with a role in maintaining redox homeostasis. And Srx has an oncogenic role in skin tumorigenes...
Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage [0.03%]
デス-パミペキソール通过减少出血性卒中后铁死亡来减轻白质损伤以促进运动功能恢复
Bo Wang,Xuyang Zhang,Jun Zhong et al.
Bo Wang et al.
Deciphering the factors causing damage to white matter fiber bundles and exploring new strategies to alleviate white matter injury (WMI) is a promising treatment to improve neurological impairments after intracerebral hemorrhage (ICH). Ferr...
Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity [0.03%]
蒽环类药物相关心脏毒性的遗传易感性和发病机制
Yonghe Ding,Ke Du,Yu-Juan Niu et al.
Yonghe Ding et al.
Anthracyclines are chemotherapeutic agents widely used to treat a variety of cancers, and these drugs have revolutionized our management of cancer patients. The dose-dependent cardiotoxicity of anthracyclines, however, remains one of the le...
Intermittent Hypoxia and Atherosclerosis: From Molecular Mechanisms to the Therapeutic Treatment [0.03%]
间断缺氧与动脉粥样硬化：从分子机制到治疗措施
Binyu Luo,Yiwen Li,Mengmeng Zhu et al.
Binyu Luo et al.
Intermittent hypoxia (IH) has a dual nature. On the one hand, chronic IH (CIH) is an important pathologic feature of obstructive sleep apnea (OSA) syndrome (OSAS), and many studies have confirmed that OSA-related CIH (OSA-CIH) has atherogen...
Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway [0.03%]
松脂衍生物IDOAMP通过激活RIPK1/RIPK3/MLKL信号通路抑制前列腺癌生长
Hong Xu,Xingkai Zeng,Xuecheng Wei et al.
Hong Xu et al.
Rosin derivatives such as dehydroabietic acid and dehydroabietic amine belonging to diterpenoids have similar structure with androgen that inhibited the occurrence and development of prostate cancer. In this study, the effects and possible ...