Contribution of Adiponectin/Carnitine Palmityl Transferase 1A-Mediated Fatty Acid Metabolism during the Development of Idiopathic Pulmonary Fibrosis [0.03%]
脂联素/肉碱棕榈酰转移酶1A介导的脂肪酸代谢在特发性肺纤维病发生中的作用研究进展
Wenjuan Wu,Guojun Zhang,Lingxiao Qiu et al.
Wenjuan Wu et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease that leads rapidly to death. The present study is aimed at discovering the in-depth pathogenesis of IPF, exploring the role of adiponectin/carnitine palm...
Alzheimer's Amyloid- β Accelerates Cell Senescence and Suppresses the SIRT1/NRF2 Pathway in Human Microglial Cells [0.03%]
阿尔茨海默病淀粉样蛋白-β加速人类小胶质细胞衰老并抑制SIRT1/NRF2信号通路
Yuqian An,Yi Li,Yujun Hou et al.
Yuqian An et al.
Microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging-related neurodegenerative diseases including Alzheimer's disease, they are malfunctioning. Here, we demonstrated that amyloi...
Transmissible Endoplasmic Reticulum Stress Mediated by Extracellular Vesicles from Adipocyte Promoting the Senescence of Adipose-Derived Mesenchymal Stem Cells in Hypertrophic Obesity [0.03%]
脂肪细胞外泌体介导的变应性肥胖小鼠间充质干细胞衰老的内质网压力传染模型
Jia Fang,Li Li,Xingguo Cao et al.
Jia Fang et al.
Hypertrophic obesity, characterized by an excessive expansion of subcutaneous adipocytes, causes chronic inflammation and insulin resistance. It is the primary feature of obesity in middle-aged and elderly individuals. In the adipose microe...
miRNAs from Plasma Extracellular Vesicles Are Signatory Noninvasive Prognostic Biomarkers against Atherosclerosis in LDLr-/-Mice [0.03%]
载有miRNA的血浆胞外囊泡是LDLr-/-小鼠动脉粥样硬化预后的特异性非侵入性生物标志物
Ke-Feng Zhai,Hong Duan,Yan Shi et al.
Ke-Feng Zhai et al.
Circular microRNAs (miRNAs) have become central in pathophysiological conditions of atherosclerosis (AS). However, the biomarkers for diagnosis and therapeutics against AS are still unclear. The atherosclerosis models in low-density lipopro...
CCAAT/Enhancer-Binding Protein Delta Regulates Glioblastoma Survival through Catalase-Mediated Hydrogen Peroxide Clearance [0.03%]
转录因子C/EBPδ通过CAT介导的H2O2清除调节胶质母细胞瘤细胞生存能力
Hong-Yi Lin,Sher-Wei Lim,Tsung-I Hsu et al.
Hong-Yi Lin et al.
It has long been documented that cancer cells show increased and persistent oxidative stress due to increased reactive oxygen species (ROS), which is necessary for their increased proliferative rate. Due to the high levels of ROS, cancer ce...
Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy [0.03%]
生物硒纳米粒子通过调节内质网应激介导的线粒体自噬来缓解肠道上皮屏障损伤
Lei Qiao,Shuqi Yan,Xina Dou et al.
Lei Qiao et al.
The intestinal barrier plays a fundamental role in body health. Intracellular redox imbalance can trigger endoplasmic reticulum stress (ERS) and mitophagy, leading to intestinal barrier damage. Our previous studies demonstrated that mitopha...
Pigment Epithelium-Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model [0.03%]
色素上皮衍生因子保护视网膜神经细胞并预防体外缺血模型中的病理性血管生成
Lei Xi,Marina Tikhonovich,Antje Biesemeier et al.
Lei Xi et al.
Ocular ischemia/hypoxia is a severe problem in ophthalmology that can cause vision impairment and blindness. However, little is known about the changes occurring in the existing fully formed choroidal blood vessels. We developed a new whole...
Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice [0.03%]
激活LRP1通过TXNIP/NLRP3信号通路抑制神经炎症和氧化应激缓解小鼠脑缺血再灌注损伤及认知障碍
Cheng-Jie Yang,Xin Li,Xiao-Qing Feng et al.
Cheng-Jie Yang et al.
Cerebral ischemia/reperfusion (I/R) injury is a clinical event associated with high morbidity and mortality. Neuroinflammation plays a crucial role in the pathogenesis of I/R-induced brain injury and cognitive decline. Low-density lipoprote...
Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer [0.03%]
识别并验证三个参与去势抵抗性前列腺癌细胞增殖和预后的中心基因
Pan Yu,Yibei Dai,Tingting Zhuang et al.
Pan Yu et al.
Background: The acquisition of castration resistance is lethal and inevitable in most prostate cancer patients under hormone therapy. However, effective biomarkers and therapeutic targets for castration-resistant prostate...
Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis [0.03%]
与氧化应激和巨噬细胞铁死亡相关的新诊断生物标志物在动脉粥样硬化中的作用
Minhui Li,Siyuan Xin,Ruiyuan Gu et al.
Minhui Li et al.
Atherosclerosis (AS) is a chronic inflammatory disease, which has a complex interplay between altered immune metabolism and oxidative stress. Therefore, we aimed to determine the oxidative stress and immune-related biomarkers in AS. Differe...