The Examination of the Influence of Caffeinated Coffee Consumption on the Concentrations of Serum Prolactin and Selected Parameters of the Oxidative-Antioxidant Balance in Young Adults: A Preliminary Report [0.03%]
咖啡因摄入对青年人血清泌乳素及部分氧化抗氧化参数影响的初步研究
Kamil Rodak,Izabela Kokot,Aleksandra Kryla et al.
Kamil Rodak et al.
We verified whether caffeinated coffee consumption influenced the concentrations of prolactin (PRL) and oxidative stress parameters: total antioxidant status (TAS), ferric reducing antioxidant power (FRAP), total oxidant status (TOS), oxida...
Adropin Improves Radiation-Induced Myocardial Injury via VEGFR2/PI3K/Akt Pathway [0.03%]
ADROPIN通过VEGFR2/PI3K/AKT途径改善辐射诱导的心肌损伤
Bingda Li,Zhenhua Wang,Yuanqiao He et al.
Bingda Li et al.
Mediastinal cancer radiotherapy exposes the heart and causes myocardial injury. It is of utmost importance to identify effective prevention and treatment targets. In this study, the regulatory role of adropin (Ad) in radiation-induced myoca...
Inhibition of c-MYC-miRNA 19 Pathway Sensitized CML K562 Cells to Etoposide via NHE1 Upregulation [0.03%]
c-MYC-miRNA 19信号通路的抑制通过上调NHE1使CML K562细胞对依托泊苷敏感化
Shannan Cao,Qingqing Xiong,Bowen Ding et al.
Shannan Cao et al.
As a previously discovered target of DNA damage, Na+/H+ exchanger 1 (NHE1) plays a role in regulation of intracellular pH (pHi) through the extrusion of intracellular proton (H+) in exchange for extracellular sodium (Na+). Its abnormal expr...
ZNF354C Mediated by DNMT1 Ameliorates Lung Ischemia-Reperfusion Oxidative Stress Injury by Reducing TFPI Promoter Methylation to Upregulate TFPI [0.03%]
DNMT1介导的ZNF354C通过降低TFPI启动子甲基化来上调TFPI，缓解肺缺血再灌注氧化应激损伤
Qi Shi,Nana Feng,Qingyun Ma et al.
Qi Shi et al.
Background: Pulmonary ischemia reperfusion- (I/R-) induced dysfunction is a significant clinical problem after lung transplantation. In this study, we aim to explore the molecular mechanism of lung I/R injury (LIRI). ...
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis [0.03%]
复发性低血糖通过诱导细胞焦亡损害2型糖尿病大鼠血管功能
Minghao Luo,Yu Hu,Dingyi Lv et al.
Minghao Luo et al.
Background: Hypoglycemia is a dangerous side effect of intensive glucose control in diabetes. Even though it leads to adverse cardiovascular events, the effects of hypoglycemia on vascular biology in diabetes have not bee...
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model [0.03%]
脑心通胶囊对急性心肌梗死大鼠能量代谢影响的实验研究
Jie Zhao,Yi Ouyang,Huanhuan Wang et al.
Jie Zhao et al.
Background: In myocardial ischemia, optimizing the myocardial metabolic phenotype to improve cardiac function is critical. Naoxintong capsules (NXT) are widely prescribed in Chinese medicine for the treatment of cerebrova...
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway [0.03%]
维生素C通过激活AMPK/Nrf2/HMOX1通路使胰腺癌细胞对Erastin诱导的铁死亡敏感
Yawen Liu,Pu Huang,Zheng Li et al.
Yawen Liu et al.
Ferroptosis is a type of regulated cell death that displays a promising therapeutic pathway for drug-resistant tumor cells. However, some pancreatic cancer (PC) cells are less sensitive to erastin-induced ferroptosis, and normal pancreatic ...
Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling [0.03%]
irisin通过激活LATS/YAP/CTGF信号通路改善椎间盘退变
Taiqiu Chen,Youxi Lin,Zizhao Wu et al.
Taiqiu Chen et al.
Unbalanced metabolism of an extracellular matrix (ECM) in nucleus pulposus cells (NPCs) is widely acknowledged as the primary cause of intervertebral disc degeneration (IDD). Irisin, a novel myokine, is cleaved from fibronectin type III dom...
Identifying a Novel Endoplasmic Reticulum-Related Prognostic Model for Hepatocellular Carcinomas [0.03%]
一种新型的与内质网相关的肝细胞癌预后模型识别方法
Fei Ding,Jinping Li,Yong Zhang et al.
Fei Ding et al.
From the standpoint of the ER (endoplasmic reticulum), we were interested in identifying hub genes that impact clinical prognosis for HCC (hepatocellular carcinoma) patients and developing an ER-related prognostic model. Using TCGA-LIHC (Th...
Integrated Analysis of Gene Expression and Methylation Data to Identify Potential Biomarkers Related to Atherosclerosis Onset [0.03%]
集成分析基因表达和甲基化数据以识别潜在的动脉粥样硬化发病生物标志物
Xiaoming Li,Xiaoqian Dong,Weidong Lu et al.
Xiaoming Li et al.
Atherosclerosis is a kind of chronic inflammatory cardiovascular disease. Epigenetic regulation plays a crucial role in atherosclerosis. Our study was aimed at finding potential biomarkers associated with the occurrence of atherosclerosis. ...