Elevated Urinary Levels of Fungal and Environmental Toxins in Patients with Pancreatic Ductal Adenocarcinoma [0.03%]
胰腺导管腺癌患者尿液中真菌和环境毒素的升高
Vanessa I Rodriguez,Jamila Mammadova,Jennifer B Permuth et al.
Vanessa I Rodriguez et al.
Background: Risk factors for pancreatic ductal adenocarcinoma (PDAC) include tobacco/alcohol abuse, genetic predisposition, insulin resistance, and pancreatic cysts. Despite these well-established risk factors and the scr...
Risk of Malignancy in Indeterminate Liver Nodules Among Patients with Cirrhosis: A Retrospective Cohort Study [0.03%]
肝硬化患者不确定性的肝脏结节恶变风险：一项回顾性队列研究
Yousef Yahia,Ma&#x;mon Qasem,Shahem Abbarh et al.
Yousef Yahia et al.
Background: Several studies have shown a higher risk of liver cancer from indeterminate liver nodules, but the exact occurrence and predictors of liver cancer in this group are still unclear. Our aim is to study the devel...
The Utility of Multitarget Stool DNA Testing for Colorectal Cancer Screening After a Normal Colonoscopy [0.03%]
正常结肠镜检查后的多靶点粪便DNA检测的效用
Abhinav K Rao,Shivam Kalra,Brett Van Leer-Greenberg et al.
Abhinav K Rao et al.
Background: Multitarget stool DNA (MT-sDNA) tests (here, Cologuard®) are currently used in average-risk patients as a primary method of screening for colorectal cancer. However, MT-sDNA testing has also been used in pati...
Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database [0.03%]
2000~2015年美国结直肠癌年轻患者性别和种族差异的动态变化：对CDC肿瘤数据库的分析
Yusuf Nawras,Nooraldin Merza,Katie Beier et al.
Yusuf Nawras et al.
Background: The mortality rates of early-onset colorectal cancer (EOCRC) have surged globally over the past two decades. While the underlying reasons remain largely unknown, understanding its epidemiology is crucial to ad...
Synergistic Effects of Fruquintinib Combined with Immune Checkpoint Inhibitors on Metastatic Colorectal Cancer [0.03%]
呋喹替尼联合免疫检查点抑制剂治疗转移性结直肠癌的协同作用研究
Ming-Zhi Xie,Yong-Qiang Li,Rong Liang et al.
Ming-Zhi Xie et al.
Background: Fruquintinib has received approval for the management of patients with chemotherapy-resistant metastatic colorectal cancer (mCRC). However, combination of fruquintinib with immune checkpoint inhibitors (ICIs) ...
Long-Term Survivor of Intrahepatic Cholangiocarcinoma for over 18 Years: Case Study with Longitudinal Histo-molecular and Tumor Immune Microenvironment Characterization and Systematic Review of the Literature [0.03%]
胆管癌长期生存者长达18余年的纵向病理-分子表征及肿瘤免疫微环境特征：病例研究和文献系统回顾
Paola Mattiolo,Mario De Bellis,Andrea Mafficini et al.
Paola Mattiolo et al.
Background: Intrahepatic cholangiocarcinoma is a biliary neoplasm usually showing a dismal prognosis. In early stages, surgical resection is the best treatment option, significantly increasing the overall survival. This a...
Saira Rafaqat,Huma Khurshid,Ramsha Hafeez et al.
Saira Rafaqat et al.
Purpose: This review article summarizes the pathophysiological aspects of interleukins (ILs) including IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, and IL-10 in pancreatic cancer (PC). ...
Exceptional Response to Pembrolizumab in HER2-Positive Gallbladder Carcinoma with High Tumor Mutational Burden [0.03%]
肿瘤突变负荷高的HER2阳性胆囊癌患者接受派姆单抗治疗的疗效分析
Akinori Sasaki,Satoru Nakajima,Yasuaki Motomura
Akinori Sasaki
Purpose: Patients with advanced cholangiocarcinoma, including gallbladder cancer, typically have a poor prognosis owing to limited effective chemotherapy options. The field of genotype-directed therapy in patients with ch...
Integrative Bioinformatics Analysis: Unraveling Variant Signatures and Single-Nucleotide Polymorphism Markers Associated with 5-FU-Based Chemotherapy Resistance in Colorectal Cancer Patients [0.03%]
整合生物信息学分析：揭示与结直肠癌患者氟尿嘧啶为基础的化疗耐药相关的变异特征和单核苷酸多态性标志物
Masomeh Askari,Ebrahim Mirzaei,Leila Navapour et al.
Masomeh Askari et al.
Background: Drug resistance in colorectal cancer (CRC) is modulated by multiple molecular factors, which can be ascertained through genetic investigation. Single nucleotide polymorphisms (SNPs) within key genes have the p...