Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression [0.03%]
体重减轻可逆转年龄和肥胖对乳腺肿瘤免疫抑制和发展的效果
Laura A Smith,Dalton M Craven,Alyssa N Ho et al.
Laura A Smith et al.
Advanced age and obesity are each a major risk factor for breast cancer progression, including triple-negative breast cancer (TNBC). Here we interrogated: a) whether these factors interact to promote TNBC progression, and b) if weight loss ...
Characteristics of the Newly Eligible Population under Two Recent Updates of Lung Cancer Screening Recommendations [0.03%]
近期肺癌筛查指南更新后的新一轮适合筛查人群特征分析
Yu Liu,Michael T Halpern,Robert J Volk et al.
Yu Liu et al.
The United States Preventive Services Task Force (USPSTF) updated its lung cancer screening (LCS) recommendation in 2021 and the American Cancer Society (ACS) updated its LCS guidelines in 2023. Each update expanded screening eligibility cr...
Cancer Incidence and Survival After Emergency Department Care in the U.S. Midwest: An Opportunity for Cancer Interception [0.03%]
美国中西部急诊科癌症发病率和患者的生存率：癌症拦截的机会
Mark E Sherman,Michael G Heckman,Christopher C DeStephano et al.
Mark E Sherman et al.
Historically, cancers diagnosed via the Emergency Department (ED) portend a poor prognosis. Recent data from the United States (U.S.) are sparse and analyses of cancers detected in the years following ED visits are lacking. Thus, we analyze...
Pre-diagnostic serum immune marker levels and multiple myeloma: A prospective longitudinal study using samples from the Janus Serum Bank in Norway [0.03%]
诊断前血清免疫标志物水平与多发性骨髓瘤：使用挪威Janus血清库样品的前瞻性纵向研究
Simona Herdenberg,Carl Wibom,Esmeralda J M Krop et al.
Simona Herdenberg et al.
Multiple myeloma (MM) is preceded by monoclonal gammopathy of undetermined significance (MGUS). Only a minority of MGUS patients will develop MM, but precise prediction of progression is impossible using routine clinical biomarkers. Changes...
Lower Neighborhood-level Socioeconomic Status is Associated with Lower Colorectal Cancer Screening Uptake in the Southern Community Cohort Study [0.03%]
较低的社区经济地位与南方社区队列研究中较低的大肠癌筛查率有关
Lauren Giurini,Ronald E Gangnon,Amy Trentham-Dietz et al.
Lauren Giurini et al.
Colorectal cancer (CRC) is highly preventable with timely screening, but screening modalities are widely underused, especially among those of low individual-level socioeconomic status (SES). In addition to individual-level SES, neighborhood...
Deriving a mammogram-based risk score from screening digital breast tomosynthesis for 5-year breast cancer risk prediction [0.03%]
从数字乳腺断层扫描中提取基于乳房X线照片的风险评分以预测五年后的乳腺癌风险
Shu Jiang,Debbie L Bennett,Graham A Colditz
Shu Jiang
Screening digital breast tomosynthesis (DBT) aims to identify breast cancer early when treatment is most effective leading to reduced mortality. In addition to early detection, the information contained within DBT images may also inform sub...
Randomized phase II clinical trial of sulforaphane in former smokers at high risk for lung cancer [0.03%]
高风险前吸烟者的随机二期临床蕨菁素实验
Jian-Min Yuan,Thomas W Kensler,Sanja Dacic et al.
Jian-Min Yuan et al.
Experimental studies have shown dietary isothiocyanates reduced cellular proliferative marker Ki-67 and increased apoptotic markers Caspase-3 and TUNEL in animals, but human data are lacking. The present study was to assess whether sulforap...
Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention [0.03%]
评估间歇性使用阿司匹林预防结直肠癌的效果
Xiangzhu Zhu,Ruohui Chen,Reid M Ness et al.
Xiangzhu Zhu et al.
Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent pre-clinical data suggest that intermittent dosing of aspirin may minimize adverse effects maintaining efficacy. We conducted a three-arm double-blind ra...
Implementing a Tribally-Engaged Lung Cancer Screening Pilot Program in Rural Oklahoma [0.03%]
在俄克拉荷马州农村地区实施部落参与的肺癌筛查试点项目
Zsolt Nagykaldi,Mark Doescher,Dorothy A Rhoades et al.
Zsolt Nagykaldi et al.
The Tribally-Engaged Approaches to Lung Cancer Screening (TEALS) study aimed to co-design and test a community-based lung cancer screening (LCS) program within a large, tribally operated health system. In 2020-2021, we conducted a pre-post ...