Mitochondrial DNA copy number assessment is a potent predictor for prostate cancer in White but not Black Individuals [0.03%]
线粒体DNA拷贝数评估可以预测白人前列腺癌但不能用于黑人
Melanie K Flores,Jessica L Janes,Mirajul Islam et al.
Melanie K Flores et al.
Black individuals are disproportionately burdened by prostate cancer compared to White individuals. The mitochondrion is an untapped source for prostate cancer (PCa) biomarkers, and previous work has shown altered mitochondrial DNA (mtDNA) ...
Genetic polymorphisms of TP53 and ApoB genes and risk of biliary tract cancer: A case-cohort study in Japan [0.03%]
日本胆道癌的遗传多态性与风险：一项基于病例队列的研究
Takao Asai,Taiki Yamaji,Shiori Nakano et al.
Takao Asai et al.
Although several retrospective studies have investigated the association of TP53 rs1042522 and ApoB rs693 with risk of biliary tract cancer (BTC), results have been inconsistent. Here, to provide evidence from a prospective study, we analyz...
Racial Health Disparity and Risk of Multiple Myeloma: Implications for Energy Balance Interventions [0.03%]
种族健康差异和多发性骨髓瘤的风险：能量平衡干预的含义
Amber J Normann,Rebekah L Wilson,Ellaney Matarese et al.
Amber J Normann et al.
Established risk factors for multiple myeloma, including obesity and sedentary lifestyles, are associated with well-known racial/ethnic disparities in disease risk. This review examines established risk determinants for multiple myeloma in ...
Gastric Cancer Origins: Stem Cells, Metaplasia, and Environmental Interactions [0.03%]
胃癌起源：干细胞、肠上皮化生和环境的相互作用
Hiroto Kinoshita,Guodong Lian,Yoku Hayakawa
Hiroto Kinoshita
The study by Morris and colleagues provides new insights into gastric cancer development, challenging the traditional Correa cascade model. Their findings show that cigarette smoke exposure accelerates dysplasia formation while reducing Hel...
Stage at Diagnosis for Common Cancers According to Rurality, Area Deprivation and Insurance, 2017-2021 [0.03%]
基于城乡、地区剥夺和保险的常见癌症诊断分期（2017-2021年）
Kathleen M Fairfield,Kimberly Murray,Lise M Cloutier et al.
Kathleen M Fairfield et al.
Poor access to care among rural and vulnerable populations may result in later stage cancer diagnoses. Using Maine Cancer Registry data (2017-2021) we examined relationships between rurality, insurance, area deprivation index (ADI), and sta...
Epigenetic changes induced by carcinogenic agents or occupational exposure with sufficient evidence for bladder cancer [0.03%]
致癌物或职业暴露所致膀胱癌的表观遗传改变（有充足证据者）
Edyta Kasperczyk,Kateryna Tarhonska,Ewa Jablonska
Edyta Kasperczyk
Extensive evidence highlights the role of epigenetic alterations in chemically induced carcinogenesis. Accordingly, this review focuses on the importance of epigenetics and exposure in bladder cancer. Specifically, we examined publications ...
Feasibility and acceptability of pay-it-forward in increasing uptake of HPV vaccination among 15-18-year-old girls in China: Pilot RCT Results [0.03%]
中国15至18岁女孩人乳头瘤病毒疫苗接种推广中“付给未来”模式可行性和可接受性的试点RCT结果分析
Yifan Li,Chuanyu Qin,Katherine T Li et al.
Yifan Li et al.
China has low human papillomavirus (HPV) vaccination rate due to limited public funding and mistrust in domestic vaccines. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary effectiveness of an innovative pay...
Clinical Evaluation of Cancer Signal Origin Prediction and Diagnostic Resolution Following Multi-Cancer Early Detection Testing in the PATHFINDER Study [0.03%]
PATHFINDER研究中多癌症早期检测后癌症信号来源预测和诊断分辨率的临床评价
Catherine R Marinac,Charles H McDonnell,Lincoln D Nadauld et al.
Catherine R Marinac et al.
Blood-based multi-cancer early detection (MCED) tests represent a new approach for cancer detection. To gain insight into the utility of various approaches of evaluating a cancer signal detected (CSD) test result, we evaluated diagnostic jo...
From therapy to cancer prevention using HRD testing on high grade ovarian cancer patients [0.03%]
用于高级别卵巢癌患者的HRD检测以进行治疗和癌症预防
Maria Grazia Tibiletti,Ileana Carnevali,Sofia Facchi et al.
Maria Grazia Tibiletti et al.
Approximately half of high-grade ovarian cancers are characterized by genetic and epigenetic alterations of genes involved in homologous recombination (HRR), most commonly BRCA1 and BRCA2. HRR defects identified by tests of genomic instabil...
Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence over 21 years of follow-up in the Diabetes Prevention Program [0.03%]
糖尿病预防计划中 metformin和强化生活方式干预对癌症发病率的21年随访随机研究
Brandy M Heckman-Stoddard,Jill P Crandall,Sharon L Edelstein et al.
Brandy M Heckman-Stoddard et al.
Meta-analyses have reported a decrease in overall cancer incidence of approximately 10-40% with metformin use among individuals with diabetes. Lifestyle change could potentially reduce cancer incidence. The objective was to determine whethe...