Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia [0.03%]
饮食二十碳五烯酸对实验性髓系白血病化学预防作用的影响
Emily R Finch,Avinash K Kudva,Michael D Quickel et al.
Emily R Finch et al.
Current therapies for treatment of myeloid leukemia do not eliminate leukemia stem cells (LSC), leading to disease relapse. In this study, we supplemented mice with eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid, a...
Effect of Metformin on Breast Ductal Carcinoma In Situ Proliferation in a Randomized Presurgical Trial [0.03%]
二甲双胍对乳腺导管原位癌增殖影响的随机术前试验研究
Andrea DeCensi,Matteo Puntoni,Aliana Guerrieri-Gonzaga et al.
Andrea DeCensi et al.
Metformin is associated with lower breast cancer risk in epidemiologic studies and showed decreased proliferation in HER2-positive breast cancer in a presurgical trial. To provide insight into its preventive potential, we measured prolifera...
Physical Activity and Prostate Tumor Vessel Morphology: Data from the Health Professionals Follow-up Study [0.03%]
来自健康专业人员随访研究的体力活动与前列腺肿瘤血管形态学的数据
Erin L Van Blarigan,John P Gerstenberger,Stacey A Kenfield et al.
Erin L Van Blarigan et al.
Vigorous activity is associated with lower risk of prostate cancer progression, but the biologic mechanisms are unknown. Exercise affects vascularization of tumors in animal models, and small, irregularly shaped vessels in prostate tumors a...
Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence [0.03%]
同时具有APC、KRAS和PIK3CA驱动基因突变的结肠肿瘤仍然通过腺瘤-癌序列进展
Jamie N Hadac,Alyssa A Leystra,Terrah J Paul Olson et al.
Jamie N Hadac et al.
Human colorectal cancers often possess multiple mutations, including three to six driver mutations per tumor. The timing of when these mutations occur during tumor development and progression continues to be debated. More advanced lesions c...
Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells [0.03%]
大豆异黄酮强化面包的摄入与前列腺癌男性的炎性细胞因子降低和免疫抑制细胞减少有关
Gregory B Lesinski,Patrick K Reville,Thomas A Mace et al.
Gregory B Lesinski et al.
We hypothesized that soy phytochemicals may have immunomodulatory properties that may affect prostate carcinogenesis and progression. A randomized, phase II trial was conducted in 32 patients with prostate cancer with asymptomatic biochemic...
Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density [0.03%]
一项双盲随机12个月大豆干预试验对乳腺MRI纤维腺体组织密度或乳腺X线摄影密度均无影响
Anna H Wu,Darcy Spicer,Agustin Garcia et al.
Anna H Wu et al.
Soy supplementation by patients with breast cancer remains controversial. No controlled intervention studies have investigated the effects of soy supplementation on mammographic density in patients with breast cancer. We conducted a double-...
Randomized Controlled Trial
Cancer prevention research (Philadelphia, Pa.). 2015 Oct;8(10):942-51. DOI:10.1158/1940-6207.CAPR-15-0125 2015
Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer [0.03%]
前列腺癌患者食用标准化的豆类和豆杏仁面包后的异黄酮药代动力学及代谢情况
Jennifer H Ahn-Jarvis,Steven K Clinton,Elizabeth M Grainger et al.
Jennifer H Ahn-Jarvis et al.
Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted in 32 men with asymptomatic prostate can...
Noninvasive molecular screening for oral precancer in Fanconi anemia patients [0.03%]
范可尼贫血患者口腔癌前病变的非侵入性分子筛查
Stephanie E Smetsers,Eunike Velleuer,Ralf Dietrich et al.
Stephanie E Smetsers et al.
LOH at chromosome arms 3p, 9p, 11q, and 17p are well-established oncogenetic aberrations in oral precancerous lesions and promising biomarkers to monitor the development of oral cancer. Noninvasive LOH screening of brushed oral cells is a p...
ERβ expression and breast cancer risk prediction for women with atypias [0.03%]
ERβ表达与女性异常增生的乳腺癌风险预测
Tina J Hieken,Jodi M Carter,John R Hawse et al.
Tina J Hieken et al.
Estrogen receptor (ER) β is highly expressed in normal breast epithelium and a putative tumor suppressor. Atypical hyperplasia substantially increases breast cancer risk, but identification of biomarkers to further improve risk stratificat...
Low SFRP1 Expression Correlates with Poor Prognosis and Promotes Cell Invasion by Activating the Wnt/β-Catenin Signaling Pathway in NPC [0.03%]
低SFRP1表达与鼻咽癌预后不良及通过激活Wnt/β-catenin信号通路促进细胞侵袭有关
Xian-Yue Ren,Guan-Qun Zhou,Wei Jiang et al.
Xian-Yue Ren et al.
Distant metastasis remains the predominant mode of treatment failure in nasopharyngeal carcinoma (NPC). Unfortunately, the molecular events underlying NPC metastasis remain poorly understood. Secreted frizzled-related protein 1 (SFRP1) play...