High frequency of the SDK1:AMACR fusion transcript in Chinese prostate cancer [0.03%]
中国前列腺癌患者中SDK1:AMACR融合转录本高频检出
Yanling Zhang,Xue-Ying Mao,Xiaoyan Liu et al.
Yanling Zhang et al.
Chromosomal rearrangements and fusion genes play important roles in tumor development and progression. Four high-frequency prostate cancer (CaP) specific fusion genes, SDK1:AMACR, RAD50:PDLIM4, CTAGE5:KHDRBS3 and USP9Y:TTTY15 have been repo...
Special computer-aided computed tomography (CT) volume measurement and comparison method for pulmonary tuberculosis (TB) [0.03%]
一种特殊类型的计算机辅助的肺结核(Ct)体积测量和比较方法
Jingming Liu,Zhaogang Sun,Ruming Xie et al.
Jingming Liu et al.
The computed tomography (CT) manifestations in pulmonary tuberculosis (PTB) patients are complex and could not be quantitatively evaluated. We aimed to establish a new method to objectively measure the lung injury level in PTB by thoracic C...
Lin28B over-expression mediates the repression of let-7 by hepatitis B virus X protein in hepatoma cells [0.03%]
HBV-X蛋白通过上调LIN28B在肝癌细胞中抑制LET-7家族微小核糖核酸的作用
Gang Wu,Pinbo Huang,Xueming Ju et al.
Gang Wu et al.
The Let-7 microRNA (miRNA) family is frequently downregulated in multiple human tumors, including hepatocellular carcinoma (HCC). Our previous report demonstrated that hepatitis B virus X protein (HBx) suppressed the expression of let-7 in ...
Apoptotic effects of Photofrin-Diomed 630-PDT on SHEEC human esophageal squamous cancer cells [0.03%]
Photofrin-Diomed 630-PDT诱导人食管癌SHEEC细胞的凋亡效应研究
Shegan Gao,Mengxi Zhang,Xiaojuan Zhu et al.
Shegan Gao et al.
Photodynamic therapy (PDT) using photofrin-II is a clinically effective treatment for both non-neoplastic and neoplastic diseases. Herein, we performed an in vitro experiment to study the anti-tumor effect and mechanisms of photofrin-II med...
Hypoxia-induced HMGB1 in would tissues promotes the osteoblast cell proliferation via activating ERK/JNK signaling [0.03%]
缺氧诱导的HMGB1促进骨膜组织中成骨细胞增殖的新机制研究
Qiang Li,Bin Yu,Peng Yang
Qiang Li
High mobility group box-B1 (HMGB1) is upregulated in tumors, inflammations, and other injuries. However, its extracellular role and signaling in wound healing remains unclear. In the present study, we examined the HMGB1 levels in hematoma s...
In vitro and in vivo effects of ethanol extract combined with Curcumae Radix and Glycyrrhizae Radix et Rhizoma on menopausal metabolic disturbances [0.03%]
体外和体内研究姜黄根和甘草根组合乙醇提取物对绝经代谢紊乱的影响
InSil Park,JinAh Ryuk,HyeWon Lee et al.
InSil Park et al.
Curcumae Radix (CR) and Glycyrrhizae Radix et Rhizoma (GR) extracts have been used as health supplements in traditional medicine. This study was performed to evaluate the effects of combined CR and GR extracts (CR+GR) on metabolic complicat...
Neuroprotection by epigallo catechin gallate against bupivacaine anesthesia induced toxicity involves modulation of PI3/Akt/PTEN signalling in N2a and SH-SY5Y cells [0.03%]
表没食子儿茶素没食子酸酯通过调节N2a和SH-SY5Y细胞中PI3/AKT/PTEN信号传导对丁卡因麻醉诱导的毒性发挥神经保护作用
Li-Yan Wang,Xia Li,Yu-Zeng Han
Li-Yan Wang
Bupivacaine, an amide type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown neurotoxicity following local administration of bupivacaine raising concerns ...
Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1 [0.03%]
大黄素通过调节SIRT1抑制HMGB1诱导的人类骨肉瘤肿瘤血管生成
Wei Qu,Yufei Wang,Qining Wu et al.
Wei Qu et al.
The anti-cancer effects of emodin, including inhibition of proliferation, invasion, metastasis and angiogenesis, were confirmed by various previous studies. However, the specific mechanisms were not clear. In this study, we investigated emo...
The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis [0.03%]
类风湿关节炎患者Treg细胞上CCR4和CCR6的异常表达
Ning Li,Wei Wei,Feng Yin et al.
Ning Li et al.
The study aims to investigate the frequency of CD4(+)CD25(+)Foxp3(+)CD127(-) T regulatory cells (Tregs) and the expression of CCR4, CCR6 and/or other chemokine receptors on Tregs in peripheral blood (PB) in patients with rheumatoid arthriti...
The miR-101/RUNX1 feedback regulatory loop modulates chemo-sensitivity and invasion in human lung cancer [0.03%]
miR-101/RUNX1反馈调节环路调控人肺癌的化疗敏感性及侵袭能力
Xianghui Wang,Yihua Zhao,Haiyun Qian et al.
Xianghui Wang et al.
The deregulation of miR-101 has been implicated in multiple cancer types including lung cancer, but the exact role, mechanisms and how silencing of miR-101 remain elusive. Here we confirmed miR-101 downregulation in lung cancer cell lines a...