Discovery of TBK1-Associated Oncogenic Mechanisms in Patients With Upper Tract Urothelial Carcinoma and Pre-Existing End-Stage Renal Disease [0.03%]
TBK1相关的上尿路尿路上皮癌与终末期肾脏疾病既往史患者的致癌机制研究发现
Yu-Pin Huang,Jen-Chieh Chen,Yu-Ching Peng et al.
Yu-Pin Huang et al.
Background: Upper tract urothelial carcinoma is an aggressive malignancy originating from the transitional epithelium of the urinary tract. UTUC patients with pre-existing end stage renal disease (ESRD) have limited perio...
Penalized-Survival Nomogram Predicts 5-Year Metastasis-Free Survival After Salvage Radiotherapy for Postprostatectomy Patients: A Multicenter Study [0.03%]
惩罚回归列线图预测挽救性放疗前列腺切除术后患者5年无转移生存率：一项多中心研究
F Mastroleo,R Villa,M Zaffaroni et al.
F Mastroleo et al.
Background/aim: Salvage radiotherapy (SRT) is a key treatment for biochemical recurrence (BCR) after radical prostatectomy (RP), yet a significant proportion of patients progress to distant metastasis. This multicenter re...
Association Between Early on-Treatment Weight Loss With Enfortumab Vedotin Plus Pembrolizumab and Survival in Advanced Urothelial Carcinoma [0.03%]
恩fortumab vedotin联合派姆单抗治疗晚期尿路上皮癌的早期减重与生存相关的研究
Ryan D Chow,Ronac Mamtani
Ryan D Chow
Background: Combination therapy with enfortumab vedotin plus pembrolizumab (EV+P) is now the preferred first-line (1L) therapy for advanced urothelial carcinoma (aUC), but prognostic indicators for patients on 1L EV+P hav...
Alon Lazarovich,Gregory Raster,Samuel Tremblay et al.
Alon Lazarovich et al.
Diagnostic Accuracy of Contrast-Enhanced Ultrasound in Differentiating RCC from AML in Small Hyperechoic Renal Masses (≤ 3 cm): A Retrospective Single-Center Study [0.03%]
对比增强超声在小等回声肾占位（≤3cm）鉴别肾癌与血管平滑肌脂肪瘤中的诊断准确性：单中心回顾性研究
Fabrizio Urraro,Nicoletta Giordano,Vittorio Patanè et al.
Fabrizio Urraro et al.
Background: Small (≤ 3 cm) hyperechoic renal masses are challenging to characterize due to overlapping features between angiomyolipomas (AMLs) and renal cell carcinomas (RCCs). Contrast-enhanced ultrasound (CEUS) offers ...
Neoadjuvant PD-1/PD-L1 Inhibitors for Muscle-Invasive Bladder Cancer: A Meta-Analysis [0.03%]
肌层浸润性膀胱癌新辅助PD-1/PD-L1抑制剂治疗的 meta 分析
Lian Hu,Jia-Wei Hu,Chang-Quan Wang et al.
Lian Hu et al.
Neoadjuvant immune checkpoint inhibitors have emerged as a potential treatment option for muscle-invasive bladder cancer (MIBC), but their comparative efficacy and safety remain unclear. This meta-analysis evaluated pathological outcomes an...
Is Active Surveillance a Suitable Approach for Bilateral Multifocal Renal Oncocytomas? The 20-Year National Cancer Institute Experience [0.03%]
国家癌症研究所的20年经验：主动监测是双侧多灶性肾乳头状瘤的合适方法吗？
Aditi Chaurasia,Shiva Singh,Noah Pinson et al.
Aditi Chaurasia et al.
Objectives: To investigate the clinical characteristics, tumor growth rate, oncologic and renal function outcomes in patients with bilateral, multifocal renal oncocytoma managed with active surveillance and/or surgery. ...
Treatment Patterns and Outcomes in Lymph-Node-Positive (pN1) Prostate Cancer: A National Cancer Database Study [0.03%]
基于全国癌症数据库的淋巴结阳性(pN1)前列腺癌的治疗模式及预后分析
Andrea Piccolini,Stephan M Korn,Zhiyu Qian et al.
Andrea Piccolini et al.
Introduction: Lymph node involvement after radical prostatectomy (pN1) is associated with worse oncologic outcomes, yet its optimal management remains controversial. We evaluated oncologic outcomes and treatment patterns ...
Reassessing the Evidence: Is Intensified Therapy Justified in Older Patients with Metastatic Hormone-Sensitive Prostate Cancer? [0.03%]
重新评估证据：更强效的治疗方案适用于转移性雄激素敏感前列腺癌的老年患者吗？
Lorenzo Dottorini,Italo Sarno,Alessandro Iaculli et al.
Lorenzo Dottorini et al.
To assess the comparative efficacy of intensified systemic treatments in older patients (≥ 65 years) with metastatic hormone-sensitive prostate cancer (mHSPC) through a network meta-analysis (NMA), and evaluate whether routine use of inten...
The Influence of Lymphovascular Invasion on T Stage Upstaging and Overall Survival in Renal Cell Carcinoma: A Population-Based Study [0.03%]
淋巴管侵犯对肾细胞癌T分期及总体生存影响的群体研究
Giacomo Musso,Giuseppe Garofano,Mai Dabbas et al.
Giacomo Musso et al.
Introduction: Lymphovascular invasion (LVI) is a recognized adverse pathological feature in renal cell carcinoma (RCC). However, its impact on staging and prognosis remains poorly defined, especially across T-stage subcat...