Heterozygous BRCA1 SNPs in the Central Functional Region are Associated With Increased Sensitivity to PARP Inhibition in Breast Cancer Cells [0.03%]
杂合BRCA1 SNP位点与乳腺癌细胞对PARP抑制剂的敏感性增加有关
Ming-Hsin Yeh,Chang-Wei Li,Ling Chen et al.
Ming-Hsin Yeh et al.
Introduction: Poly (ADP-ribose) polymerase (PARP) inhibitors demonstrate efficacy in breast cancer patients harboring pathogenic BRCA1/2 mutations. However, certain BRCA1 single nucleotide polymorphisms may alter protein ...
Patients With Luminal Breast Carcinoma: The State of the Field in Proteomic and Proteogenomic Molecular Subtyping [0.03%]
luminal型乳腺癌患者的分子分型现状：从蛋白质组学到蛋白基因组学
Michal Alexovič,Ján Sabo,Pavel Bouchal
Michal Alexovič
The subtyping of breast carcinoma (BC) is essential for an accurate diagnosis, prognosis, and treatment decisions. Histopathological evaluation and immunohistochemical analysis are standard methods for clinical stratification of patients wi...
The Xpert Breast Cancer Insight Test Predicts Distant Recurrence and Overall Survival in ER-Positive, HER2-Negative Early Breast Cancer [0.03%]
Xpert乳腺癌洞察检测在雌激素受体阳性、HER2阴性早期乳腺癌患者中预测远处复发和总生存期
Martin Filipits,Viktoria Gruber,Christian F Singer et al.
Martin Filipits et al.
Background: The aim of this study was to validate the Xpert Breast Cancer Insight (BC Insight) test. BC Insight is a multigene assay consisting of three target genes and three reference genes. ...
Breast Cancer Location Predicts Sentinel Lymph Node Metastasis in Clinically Node Negative Patients With Invasive Breast Cancer Treated With Upfront Surgery [0.03%]
乳腺癌的位置能够预测临床检查阴性的浸润性乳腺癌患者在初始手术后的哨点淋巴结转移状况
Nazia Riaz,Nizar AbuOddus,Hafsteinn Peturson et al.
Nazia Riaz et al.
Background: Assessment of clinicopathological factors is standard for predicting the sentinel lymph node (SLN) status in patients with clinically node negative breast cancer. Limited studies have specifically addressed th...
Long-Term Clinical Outcomes and Cost-Utility Analysis of Prepectoral Versus Subpectoral Implant-Based Breast Reconstruction Following Nipple-Sparing Mastectomy: A Multicenter Retrospective Cohort Study [0.03%]
乳头保留乳房切除术后胸前与胸下假体乳房重建的长期临床疗效及成本效益分析：一项多中心回顾性队列研究
Federica Grieco,Marco Driutti,Emma Zanin et al.
Federica Grieco et al.
Background: Immediate direct-to-implant (DTI) reconstruction after nipple-sparing mastectomy (NSM) can be performed prepectorally or subpectorally, with variable use of implant-supporting mesh. We compared long-term clini...
Additional Landmark and RMST Analyses Addressing Immortal Time Bias in the Evaluation of Autologous Formalin-Fixed Tumor Vaccine for Metastatic Breast Cancer [0.03%]
额外的地标和RMST分析：解决自体甲醛固定肿瘤疫苗治疗转移性乳腺癌评价中的“永生时间”偏倚问题
Tsubasa Miyazaki,Fumito Kuranishi,Tadao Ohno
Tsubasa Miyazaki
Axillary Management After Neoadjuvant Endocrine Therapy in HR-Positive/HER2-Negative Breast Cancer [0.03%]
HR阳性/her2阴性乳腺癌新辅助内分泌治疗后的腋窝处理
Zhangqi Gu,Yuye Zhang,Yuan Ye et al.
Zhangqi Gu et al.
To provide a clinically focused review of axillary management after neoadjuvant endocrine therapy (NET) in hormone receptor-positive/HER2-negative breast cancer and to define where selective de-escalation appears reasonable in current pract...
Health-Related Quality of Life in Early Breast Cancer Treatment and Effects of Surgery Type and Body Mass Index [0.03%]
乳腺癌治疗中的生命质量及手术类型和体质指数的影响
Alexa J Taghian,Mahek Aggarwal,Amy M Shui et al.
Alexa J Taghian et al.
Background: To evaluate health-related quality of life (HRQoL) and its specific domains (physical, social/family, emotional, functional, and breast cancer-specific well-being) and to examine HRQoL and the impact of clinic...
Effect of Treatment Sequencing in Older Adults With Early Breast Cancer. Insights From a Retrospective Single-Institution Cohort [0.03%]
老年早期乳腺癌患者的治疗顺序效果。单中心回顾性队列的见解
Yael Berner-Wygoda,Shabbir Mh Alibhai,Jacqueline Savill et al.
Yael Berner-Wygoda et al.
Background: Older adults (OA) account for nearly half of new breast cancer (BC) diagnoses, yet the effect of chemotherapy sequencing on treatment tolerability in OA treated with curative intent is poorly defined. ...
Is Breast Conserving Surgery Oncologically Safe for Patients With Multiple Ipsilateral Breast Cancers? A Systematic Review and Meta-analysis [0.03%]
保乳手术对多原发乳腺癌患者的安全性如何？系统评价和 meta 分析
Reem Althawadi,Reem Y Albuainain,Noora F Ali et al.
Reem Althawadi et al.
Background: The incidence of multiple ipsilateral breast cancers (MIBC), which includes multifocal and multicentric tumors, is increasing. Despite breast conserving surgery (BCS) being the mainstay of treatment in early b...