Genetic Association Analysis Implicates Six MicroRNA-Related SNPs With Increased Risk of Breast Cancer in Australian Caucasian Women [0.03%]
基因关联分析揭示六种与乳腺癌增加风险相关的澳大利亚高加索女性遗传微小核糖核酸相关变异
K M Taufiqul Arif,Gabrielle Bradshaw,Thanh T N Nguyen et al.
K M Taufiqul Arif et al.
Introduction: Breast cancer (BC), a heterogeneous disease, features microRNA-related single nucleotide polymorphisms (miRSNPs) as underlying factors of BC development, thus providing targets for novel diagnostic and thera...
Long-term Survival Comparison of Repeated Breast-conserving Surgery Versus Mastectomy for Patients with DCIS with Ipsilateral Breast Tumor Recurrence: A Real-world Longitudinal Study [0.03%]
对侧乳房肿瘤复发的DCIS患者接受多次保乳手术与乳房切除术长期生存比较：一项真实世界纵向研究
Qing Li,Kang Wang,Ling Yang et al.
Qing Li et al.
Background: Although patients diagnosed with ductal carcinoma in situ (DCIS) harbor excellent overall survival (OS) after breast-conserving therapy, the evidence regarding to surgical management for ipsilateral breast tum...
Comparative Study
Clinical breast cancer. 2021 Aug;21(4):360-372. DOI:10.1016/j.clbc.2021.02.012 2021
Diagnostic Performance of Adjunctive Imaging Modalities Compared to Mammography Alone in Women with Non-Dense and Dense Breasts: A Systematic Review and Meta-Analysis [0.03%]
与单独乳腺X线摄影相比，辅助影像学检查手段在非致密型及致密型乳腺中的诊断性能：系统评价和Meta分析
Ibrahim Hadadi,William Rae,Jillian Clarke et al.
Ibrahim Hadadi et al.
Purpose: To compare the diagnostic performance of mammography (MG) alone versus MG combined with adjunctive imaging modalities, including handheld ultrasound (HHUS), automated breast ultrasound (ABUS), digital breast tomo...
Competing-Risk Nomograms for Predicting the Prognosis of Patients With Infiltrating Lobular Carcinoma of the Breast [0.03%]
用于预测乳腺浸润性小叶癌患者预后的竞争风险预测模型
Fengshuo Xu,Chengzhuo Li,Xiang Li et al.
Fengshuo Xu et al.
Background: Infiltrating lobular carcinoma (ILC) is the second most common histologic subtype of breast cancer. We assessed the rates of cause-specific death in ILC patients with the aim of establishing competing-risk nom...
Thermal Ablation as an Alternative for Surgical Resection of Small (≤ 2 cm) Breast Cancers: A Meta-Analysis [0.03%]
热消融治疗小乳腺癌(< =2厘米)的手术切除的替代疗法:一项Meta分析研究
Elles M F van de Voort,Gerson M Struik,Erwin Birnie et al.
Elles M F van de Voort et al.
Women with early-stage breast cancer have an excellent prognosis with current therapy, but could presumably be treated less invasively, without the need for surgery. The primary goal of this meta-analysis was to examine whether thermal abla...
Locoregional Management of the Axilla in Mastectomy Patients with One or Two Positive Sentinel Nodes: The Role of Intraoperative Pathology [0.03%]
乳腺癌根治术后1-2枚阳性前哨淋巴结的腋窝处理：术中病理的作用
John Davis Jr,Judy C Boughey,Tanya L Hoskin et al.
John Davis Jr et al.
Introduction: Controversy exists regarding optimal management of the axilla in clinically node-negative (cN0) mastectomy patients with one or two positive sentinel lymph nodes (+SLNs). We evaluated the influence of frozen...
A Phase I/Ib Trial of PD 0332991 (Palbociclib) and T-DM1 in HER2-Positive Advanced Breast Cancer After Trastuzumab and Taxane Therapy [0.03%]
帕博西尼联合T-DM1治疗接受过曲妥珠单抗和紫杉烷治疗的HER2阳性晚期乳腺癌I期/Ib期临床试验
Barbara Haley,Kiran Batra,Sunati Sahoo et al.
Barbara Haley et al.
Background: Preclinical breast cancer models with acquired HER2 resistance exhibit decreased proliferation with CDK4/6 inhibition in tumors with intact Rb and low p16 levels. Adding cytotoxic agents like T-DM1 enhances th...
Clinical Trial
Clinical breast cancer. 2021 Oct;21(5):417-424. DOI:10.1016/j.clbc.2021.03.005 2021
Uridine Glucuronosyltransferase 2B7 Polymorphism-Based Pharmacogenetic Dosing of Epirubicin in FEC Chemotherapy for Early-Stage Breast Cancer [0.03%]
基于UDP葡萄糖醛酸转移酶2B7基因多态性的TFC化疗中表阿霉素个体化剂量研究
Anil A Joy,Larissa J Vos,Edith Pituskin et al.
Anil A Joy et al.
Background: Epirubicin is metabolized by uridine glucuronosyltransferase 2B7 (UGT2B7). Patients homozygous for the minor allele (CC) in the UGT2B7 -161 promoter polymorphism have lower clearance and significantly higher r...
Rapid Assessment of Resection Margins During Breast Conserving Surgery Using Intraoperative Flow Cytometry [0.03%]
应用术中流式细胞仪进行乳房肿瘤局部切除时切缘的快速测定
George Vartholomatos,Haralambos Harissis,Maria Andreou et al.
George Vartholomatos et al.
Background: Positive margins are the most important factor for recurrence of the disease after breast-conserving surgery. Several methods have been developed throughout the years to evaluate the margin status during surge...
Breast-Conserving Surgeries With and Without Cavity Shave Margins Have Different Re-excision Rates and Associated Overall Cost: Institutional and Patient-Driven Decisions for Its Utilization [0.03%]
乳房保存手术中是否刮除切缘对再次手术率及总体花费的影响：其应用的相关机构及患者因素分析
Lorraine Colón Cartagena,Kandace McGuire,Patricija Zot et al.
Lorraine Colón Cartagena et al.
Background: Reducing the rate of margin positivity and reoperations remains a paramount goal in breast-conserving surgery (BCS). This study assesses the effectiveness of standard partial mastectomy with cavity shave margi...