Deborah J Springer,Sujal Phadke,Blake Billmyre et al.
Deborah J Springer et al.
Cryptococcus gattii is an environmentally occurring pathogen that is responsible for causing cryptococcosis marked by pneumonia and meningoencephalitis in humans and animals. C. gattii can form long-term associations with trees and soil res...
Michail S Lionakis
Michail S Lionakis
Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when pe...
Cryptococcus-Related Immune Reconstitution Inflammatory Syndrome(IRIS): Pathogenesis and Its Clinical Implications [0.03%]
新发和复发型隐球菌病相关免疫重建炎性综合征(IRIS)的发病机制及临床意义
Darin L Wiesner,David R Boulware
Darin L Wiesner
This review provides an overview of Cryptococcus neoformans immunology and focuses on the pathogenesis of Cryptococcus-related paradoxical immune reconstitution inflammatory syndrome (IRIS). Cryptococcal IRIS has three phases: (1) before an...
Jose Sifuentes-Osornio,Dora E Corzo-León,L Alfredo Ponce-de-León
Jose Sifuentes-Osornio
The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also be...
Luis R Martinez,Bettina C Fries
Luis R Martinez
The use of indwelling medical devices is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms. Fungal biofilms have emerged as a clinical...
Frank L van de Veerdonk,Mihai G Netea
Frank L van de Veerdonk
It has been long appreciated that protective immunity against fungal pathogens is dependent on activation of cellular adaptive immune responses represented by T lymphocytes. The T-helper (Th)1/Th2 paradigm has proven to be essential for the...
Melissa D Johnson,John R Perfect
Melissa D Johnson
Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical expe...
Jennifer Le,Daryl S Schiller
Jennifer Le
Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized...
L Corbin Downey,P Brian Smith,Daniel K Benjamin Jr et al.
L Corbin Downey et al.
Neonatal candidiasis is serious and often fatal. Blood culture, the standard for diagnosis, has a sensitivity of 50% or less, and isolate speciation and susceptibility takes several days. This review explores recent advances in Candida dete...
Chelsea Marie,Theodore C White
Chelsea Marie
Antifungal resistance caused by mutations of the drug target, overexpression of the drug target, and drug efflux by the upregulation of transporters is increasingly common. Recently our understanding of fungal drug resistance has been advan...