The Role of Biomarkers for Diagnosis of and Therapeutic Decisions Related to Invasive Aspergillosis in Children [0.03%]
儿童侵袭性曲霉病诊断及治疗相关的生物标志物的作用
Brian T Fisher
Brian T Fisher
Invasive aspergillosis (IA) is a feared opportunistic infection for many immuncompromised children resulting in significant morbidity and mortality. Timely diagnosis based on traditional testing modalities and clinical evaluation has proven...
Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections [0.03%]
开拓进取：侵袭性真菌感染新的治疗策略的证据
C Orla Morrissey
C Orla Morrissey
Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late w...
Deborah J Springer,Sujal Phadke,Blake Billmyre et al.
Deborah J Springer et al.
Cryptococcus gattii is an environmentally occurring pathogen that is responsible for causing cryptococcosis marked by pneumonia and meningoencephalitis in humans and animals. C. gattii can form long-term associations with trees and soil res...
Michail S Lionakis
Michail S Lionakis
Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when pe...
Cryptococcus-Related Immune Reconstitution Inflammatory Syndrome(IRIS): Pathogenesis and Its Clinical Implications [0.03%]
新发和复发型隐球菌病相关免疫重建炎性综合征(IRIS)的发病机制及临床意义
Darin L Wiesner,David R Boulware
Darin L Wiesner
This review provides an overview of Cryptococcus neoformans immunology and focuses on the pathogenesis of Cryptococcus-related paradoxical immune reconstitution inflammatory syndrome (IRIS). Cryptococcal IRIS has three phases: (1) before an...
Jose Sifuentes-Osornio,Dora E Corzo-León,L Alfredo Ponce-de-León
Jose Sifuentes-Osornio
The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also be...
Luis R Martinez,Bettina C Fries
Luis R Martinez
The use of indwelling medical devices is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms. Fungal biofilms have emerged as a clinical...
Frank L van de Veerdonk,Mihai G Netea
Frank L van de Veerdonk
It has been long appreciated that protective immunity against fungal pathogens is dependent on activation of cellular adaptive immune responses represented by T lymphocytes. The T-helper (Th)1/Th2 paradigm has proven to be essential for the...
Melissa D Johnson,John R Perfect
Melissa D Johnson
Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical expe...
Jennifer Le,Daryl S Schiller
Jennifer Le
Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized...