Fundament and Prerequisites for the Application of an Antifungal TDM Service [0.03%]
开展抗真菌药物治疗药物监测服务的基础和先决条件
Roger J M Brüggemann,Rob E Aarnoutse
Roger J M Brüggemann
Therapeutic drug monitoring (TDM) involves the measurement of plasma or serum drug concentration to adapt dosages to achieve predefined target concentrations that are associated with optimal clinical response while minimizing the chance of ...
Large-Scale Chromosomal Changes and Associated Fitness Consequences in Pathogenic Fungi [0.03%]
致病真菌中的大规模染色体重排及其适应性后果
Anja Forche
Anja Forche
Pathogenic fungi encounter many different host environments to which they must adapt rapidly to ensure growth and survival. They also must be able to cope with alterations in established niches during long-term persistence in the host. Many...
Combat-Related Invasive Fungal Wound Infections [0.03%]
combat-related invasive fungal wound infections
David R Tribble,Carlos J Rodriguez
David R Tribble
Combat-related invasive fungal (mold) wound infections (IFIs) have emerged as an important and morbid complication following explosive blast injuries among military personnel. Similar to trauma-associated IFI cases among civilian population...
Candida albicans Niche Specialization: Features That Distinguish Biofilm Cells from Commensal Cells [0.03%]
白色念珠菌生态位特化：区分生物膜细胞和共生细胞的特征
Sanna E Herwald,Carol A Kumamoto
Sanna E Herwald
The fungus Candida albicans is a frequent commensal colonizer of the human gastrointestinal (GI) tract, but is also an opportunistic pathogen. This review explores features that distinguish the colonizing and pathogenic forms of C. albicans...
Michael K Mansour,Jennifer L Reedy,Jenny M Tam et al.
Michael K Mansour et al.
Cryptococcus species are fungal pathogens that are a leading cause of mortality. Initial inoculation is through the pulmonary route and, if disseminated, results in severe invasive infection including meningoencephalitis. Macrophages are th...
Zubair Ansari,Darlene Miller,Anat Galor
Zubair Ansari
Fungal keratitis remains a challenging and often elusive diagnosis in geographic regions where it is endemic. Marred by delays in diagnosis, the sequelae of corneal fungal infections, though preventable, can be irreversible. Recent studies ...
Garry T Cole,Brady J Hurtgen,Chiung-Yu Hung
Garry T Cole
Coccidioidomycosis (San Joaquin Valley fever) is a human respiratory disease caused by a soil-borne mold, and is recognized as an intransigent microbial infection by physicians who treat patients with the potentially life-threatening, disse...
Immunomodulation Therapy for Invasive Aspergillosis: Discussion on Myeloid Growth Factors, Recombinant Cytokines, and Antifungal Drug Immune Modulation [0.03%]
侵袭性曲霉菌病的免疫调节治疗：髓样生长因子、重组细胞因子和抗真菌药物免疫调节讨论
Amar Safdar
Amar Safdar
Understanding fungal pathogenesis and host-pathogen immune interaction at various stages of infection is critical to examine strategies for bolstering antifungal immune defenses. Recombinant myeloid growth factors, especially granulocyte-ma...
The Role of Biomarkers for Diagnosis of and Therapeutic Decisions Related to Invasive Aspergillosis in Children [0.03%]
儿童侵袭性曲霉病诊断及治疗相关的生物标志物的作用
Brian T Fisher
Brian T Fisher
Invasive aspergillosis (IA) is a feared opportunistic infection for many immuncompromised children resulting in significant morbidity and mortality. Timely diagnosis based on traditional testing modalities and clinical evaluation has proven...
Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections [0.03%]
开拓进取：侵袭性真菌感染新的治疗策略的证据
C Orla Morrissey
C Orla Morrissey
Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late w...