Candidiasis of the Central Nervous System in Neonates and Children with Primary Immunodeficiencies [0.03%]
中枢神经系统念珠菌病在原发性免疫缺陷患儿中的发生率及危险因素分析
Rebecca A Drummond,Michail S Lionakis
Rebecca A Drummond
Purpose of review: Candida infections of the central nervous system (CNS) are a life-threatening complication of invasive infections that most often affect vulnerable groups of patients, including neonates and children wi...
Malcolm Richardson,Iain Page
Malcolm Richardson
Purpose of review: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant ...
Nina T Grossman,Tom M Chiller,Shawn R Lockhart
Nina T Grossman
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There...
The Management of Chronic Pulmonary Aspergillosis: The UK National Aspergillosis Centre Approach [0.03%]
慢性肺曲霉病的治疗：英国国家曲霉病中心的治疗方法
Firas Maghrabi,David W Denning
Firas Maghrabi
Purpose of review: Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbid...
An invisible threat: mutation-mediated resistance to triazole drugs in Aspergillus [0.03%]
唑类药物抗性曲霉的隐形威胁——突变介导的耐药性
Cau D Pham,Shawn R Lockhart
Cau D Pham
Aspergillosis has emerged as an important contributor to infection-related morbidity and mortality in susceptible populations. This comes at a time when we are also seeing an increase in the vulnerable populations themselves. At the same ti...
Prevention of Invasive Aspergillosis in High-Risk Patients: Universal Versus Preemptive, Targeted Treatment [0.03%]
高危患者侵袭性曲霉病的一级预防：普适策略与预警靶向治疗
John W Baddley,Senu Apewokin
John W Baddley
Invasive aspergillosis (IA) is associated with increased morbidity and mortality, and there is a need for better preventative and therapeutic approaches. Successful treatment of documented IA remains difficult, often because of the inabilit...
Christina A Cuomo
Christina A Cuomo
Purpose of review: Comparative genome sequencing studies of human fungal pathogens enable identification of genes and variants associated with virulence and drug resistance. This review describes current approaches, resou...
Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status [0.03%]
侵袭性曲霉病诊断的侧向流动分析法：现状
Sven Heldt,Martin Hoenigl
Sven Heldt
Purpose of review: Diagnosis during early stages of invasive aspergillosis (IA) and targeted antifungal treatment has the potential to improve survival significantly. Despite advances in the diagnostic arsenal, invasive m...
Adilia Warris,Thomas Lehrnbecher
Adilia Warris
Purpose of review: This review summarizes the fungal diagnostic measures currently available for use in paediatric patients at high risk for developing invasive fungal disease (IFD) and those suspected of having an IFD. T...
Craig Williams,Ranjith Ranjendran,Gordon Ramage
Craig Williams
For a long time, the microbiology of cystic fibrosis has been focussed on Pseudomonas aeruginosa and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts ...