Azole-resistant Aspergillus and Echinocandin-resistant Candida - What are the treatment options? [0.03%]
曲霉菌对唑类耐药和念珠菌对棘白菌素耐药——治疗选择有哪些？
Alison R Novak,Mary E Bradley,Tyree H Kiser et al.
Alison R Novak et al.
Purpose of review: This review summarizes current treatment options for echinocandin-resistant Candida spp. (ERC) and azole-resistant Aspergillus fumigatus (ARAF), emphasizing recent in vitro/in vivo data, clinical report...
David R Tribble,Anuradha Ganesan,Carlos J Rodriguez
David R Tribble
Purpose of review: This review highlights research from the past five years on combat trauma-related invasive fungal wound infections (IFIs) with a focus on risk stratification to aid patient management, microbiology, and...
Michail S Lionakis
Michail S Lionakis
Purpose of review: Fungal infections cause significant mortality in patients with acquired immunodeficiencies including AIDS, hematological malignancies, transplantation, and receipt of corticosteroids, biologics or small...
Challenges in the Diagnosis of Invasive Fungal Infections in Immunocompromised Hosts [0.03%]
免疫抑制宿主侵袭性真菌感染诊断的挑战
Spinello Antinori,Mario Corbellino,Carlo Parravicini
Spinello Antinori
Purpose of review: The expanding population of immunocompromised patients coupled with the recognition of a growing number of different species of fungi responsible for diseases in such hosts makes the diagnosis of invasi...
Pros and Cons of Extrapolating Animal Data on Antifungal Pharmacodynamics to Humans [0.03%]
外推动物抗真菌药理动力学数据到人类的利弊分析
Scott W Mueller,Tyree H Kiser
Scott W Mueller
Both the incidence of invasive fungal infections and the number of antifungal agents available to clinicians have expanded significantly over the past two decades. Successes with pharmacokinetic and pharmacodynamic evaluations of other anti...
Applying Pharmacogenomics to Antifungal Selection and Dosing: Are We There Yet? [0.03%]
药物基因组学在抗真菌药选择和用药剂量中的应用：我们准备好了吗？
Matthew A Miller,Yee Ming Lee
Matthew A Miller
Purpose of review: This review summarizes recent literature for applying pharmacogenomics to antifungal selection and dosing, providing an approach to implementing antifungal pharmacogenomics in clinical practice. ...
An Approach to a Pulmonary Infiltrate in Solid Organ Transplant Recipients [0.03%]
实体器官移植受者出现肺渗出性病变的处理方法
Jason A Trubiano,Sharon Chen,Monica A Slavin
Jason A Trubiano
The onset of a pulmonary infiltrate in a solid organ transplant (SOT) recipient is both a challenging diagnostic and therapeutic challenge. We outline the potential aetiologies of a pulmonary infiltrate in a SOT recipient, with particular a...
Victoria M Stevens,Scott W Mueller,Paul M Reynolds et al.
Victoria M Stevens et al.
Purpose of review: This article aimed to review animal models of antifungals and identifies human literature to assess if the extrapolation of results is reliable. ...
Fungal Infections with Ibrutinib and Other Small-Molecule Kinase Inhibitors [0.03%]
伊布替尼和其他小分子激酶抑制剂的真菌感染
Marissa A Zarakas,Jigar V Desai,Georgios Chamilos et al.
Marissa A Zarakas et al.
Purpose of review: Small molecule kinase inhibitors (SMKIs) have revolutionized the management of malignant and autoimmune disorders. Emerging clinical reports point toward an increased risk for invasive fungal infections...
(New) Methods for Detection of Aspergillus fumigatus Resistance in Clinical Samples [0.03%]
新型检出临床标本中烟曲霉耐药的方法
Jeffrey D Jenks,Birgit Spiess,Dieter Buchheidt et al.
Jeffrey D Jenks et al.
Purpose of review: The incidence of invasive aspergillosis has increased substantially over the past few decades, accompanied by a change in susceptibility patterns of Aspergillus fumigatus with increasing resistance obse...