Sevoflurane induces endoplasmic reticulum stress mediated apoptosis inmouse hippocampal neuronal HT22 cells via modulating miR-15b-5p/Rab1A signaling pathway [0.03%]
异氟烷通过调控miR-15b-5p/Rab1A信号通路诱导小鼠海马HT22神经元细胞内质网应激介导的凋亡
Yongliang Li,Haijie Xia,Liangliang Chen et al.
Yongliang Li et al.
Sevoflurane (Sev) is a widely used anaesthetic agent in clinical patients. Growing evidences indicated that Sev resulted in cognitive impairment via inducing endoplasmic reticulum (ER) stress mediated neurons apoptosis in vivo. However, the...
Protective effects of mesenchymal stem cell cond tional medium against inflammatory injury on human gingival fibroblast [0.03%]
人牙龈纤维母细胞的炎症损伤向间充质干细胞凝集素介质的保护作用
Changhao Zhen,Haiyu Zhu,Qiaoling Li et al.
Changhao Zhen et al.
Mesenchymal stem cells (MSCs) alleviate oxidative stress in kidney, lung and heart by secreting bioactive factors. Human gingival fibroblasts (HGFs) are important for repairing periodontal tissues. This study observed protective effects of ...
Platelet-derived growth factor and stromal cell-derived factor-1 promote the skin wound repairing effect of bone mesenchymal stem cells: a key role of matrix metalloproteinase 1 and collagens [0.03%]
血小板源性生长因子和基质细胞衍生因子-1促进骨髓间充质干细胞的创面修复作用：基质金属蛋白酶1及胶原发挥了关键作用
Hailong Xu,Hui Zhang,Yue Ding
Hailong Xu
Bone marrow mesenchymal stem cells (BMSCs) have been applied to treatment of skin wounds. In the current study, the effect of BMSCs on secretion of several cytokines during skin wound healing was investigated. In addition, the mechanism und...
Role of AP-1 in the tobacco smoke-induced urocystic abnormal cell differentiation and epithelial-mesenchymal transition in vivo [0.03%]
活体中AP-1在烟草烟雾诱导的膀胱上皮细胞分化和上皮间充质转化中的作用研究
Yi Wang,Hao Geng,Li Zhao et al.
Yi Wang et al.
Bladder cancer is believed to arise after a series of progressive pathological changes. Cell differentiation exists in almost all cells, when become aberrant, can initiate or promote diseases processes and tumorigenesis. Epithelial-mesenchy...
Overexpression of p58ipk protects neuroblastoma against paraquat-induced toxicity [0.03%]
过表达p58ipk可保护神经母细胞瘤免受百草枯诱导的毒性影响
Fengrui Li,Biao Ge,Alatangaole Damirin
Fengrui Li
Background: Paraquat (PQ) is a powerful pathologic pesticide that contribute to the neurotoxicity, however, the pathogenic mechanism between them was unclear. The aims of this study were to explore the underlying mechanis...
High-grade serous ovarian and fallopian tube carcinomas with similar clinicopathological characteristics might originate from serous tubal intraepithelial carcinoma in Chinese women [0.03%]
中国女性类似临床病理特征的高级别浆液性卵巢癌和输卵管癌可能起源于输卵管内膜上皮瘤变
Jingmei Wang,Hongyan Wu,Yan Zhang et al.
Jingmei Wang et al.
Aims: This study aimed to compare the clinicopathological features, incidence, and prognosis between type II ovarian carcinoma (OC) and fallopian tube carcinoma (FTC) in Chinese women and to analyze the origin of high-gra...
MicroRNA-641 inhibits lung cancer cells proliferation, metastasis but promotes apoptosis in cells by targeting PDCD4 [0.03%]
微小核糖核酸-641通过靶向PDCD4抑制肺癌细胞增殖和转移但促进细胞凋亡
Jin Zhou,Hao Li,Na Li et al.
Jin Zhou et al.
Dysregulation of microRNAs (miRNAs) are found in various human cancers, but the roles of miR-641 in lung cancer are still unclear. Our purpose is to explore miR-641 effects on the cellular behavior of A549 cells and the related molecular me...
Overexpression of CTHRC1 in human melanoma promotes tumorigenesis targeted by miRNA155 [0.03%]
CTHRC1在黑色素瘤中的过表达促进肿瘤发生及其对miR155的靶向作用
Yuan Li,Yujie Zhang,Chong Ma et al.
Yuan Li et al.
Most of human malignant melanoma is metastatic and invasive, which has poor therapeutic response and poor prognosis as well as high incidence worldwide. CTHRC1 was overexpressed in metastatic primary melanomas. The relationship between CTHR...
Roles of lncRNA UCA1-miR-18a-SOX6 axis in preventing hypoxia injury following cerebral ischemia [0.03%]
长链非编码RNA UCA1通过调节miR-18a-SOX6轴预防脑缺血再灌注损伤中的缺氧损伤作用机制研究
Jianying Tian,Haiming Xu,Guisheng Chen et al.
Jianying Tian et al.
The present study aimed to elucidate the roles and possible molecular mechanisms of long noncoding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) in neuronal pheochromocytoma (PC)-12 cells under hypoxic conditions. The neuronal PC-12...
Neuron-derived netrin-1 and netrin-4 proteins are additional effective targets in diabetic retinopathy beyond VEGF [0.03%]
神经衍生的netrin-1和netrin-4蛋白是糖尿病视网膜病变中VEGF以外的有效靶标
Bowen Cao,Xuxia Meng,Yudong Fu et al.
Bowen Cao et al.
Vascular endothelial growth factor (VEGF) is the typical representative factor of diabetic retinopathy (DR) and is considered to be a key inducer of retinal vascular permeability in DR. Anti-VEGF has been widely used in clinical treatment b...