Modafinil alone and in combination with low dose amphetamine does not establish conditioned place preference in male Sprague-Dawley rats [0.03%]
莫达非尼及其与低剂量苯丙胺联合使用对雄性Spraque-Dawley大鼠不产生条件位置偏好作用
Amanda J Quisenberry,Thomas E Prisinzano,Lisa E Baker
Amanda J Quisenberry
Modafinil is a novel wake-promoting drug with FDA approval for the treatment of narcolepsy, shift work sleep disorder, and sleep apnea. It is also prescribed for many off-label uses such as ADHD and it is currently being assessed as a treat...
Test-retest reliability and construct validity of the Experiential Discounting Task [0.03%]
经验折扣任务的测试-重测信度和构建效度
Rochelle R Smits,Jeffrey S Stein,Patrick S Johnson et al.
Rochelle R Smits et al.
Delay discounting (the devaluation of delayed rewards) has been studied extensively using animal models with psychophysical adjustment procedures. Similar procedures have been developed to assess delay discounting in humans and these proced...
Investigating group contingencies to promote brief abstinence from cigarette smoking [0.03%]
团体连锁干预促进吸烟者短暂戒烟效果的探索性研究
Steven E Meredith,Jesse Dallery
Steven E Meredith
In contingency management (CM), monetary incentives are contingent on evidence of drug abstinence. Typically, incentives (e.g., "vouchers" exchangeable for goods or services) are contingent on individual performance. We programmed vouchers ...
Krysten W Bold,Haewon Yoon,Gretchen B Chapman et al.
Krysten W Bold et al.
This study aimed to expand the current understanding of smoking maintenance mechanisms by examining how putative relapse risk factors relate to a single behavioral smoking choice using a novel laboratory smoking-choice task. After 12 hr of ...
An event-level examination of sex differences and subjective intoxication in alcohol-related aggression [0.03%]
基于事件的性别差异和饮酒主观感受对酒精相关攻击行为的影响研究
Patrick D Quinn,Cynthia A Stappenbeck,Kim Fromme
Patrick D Quinn
Laboratory-based experimental research has demonstrated that the pharmacological effects of alcohol can increase aggressive responding. Given mixed findings and concerns regarding task validity, however, it remains uncertain whether this ef...
Modulating roles of smoking status and sex on oxycodone-induced nausea and drug liking [0.03%]
吸烟状况和性别在羟考酮致恶心及欣快感中的调制作用
James P Zacny,Sean M Apfelbaum,Kenneth A Perkins
James P Zacny
Two prominent and important risk factors for nonmedical use of prescription opioids (NMUPO) identified in epidemiological studies are smoking status and sex (i.e., there is a greater likelihood of NMUPO in smokers and in men, relative to no...
Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats [0.03%]
预测酒精和蔗糖自身给药的灭绝和复归在杂交大鼠中的情况
Therese A Kosten,Richard A Meisch
Therese A Kosten
Preventing relapse to drinking or escalation to excessive drinking could be aided by identifying factors that predict these behaviors. Animal models, particularly those that utilize operant self-administration techniques, can be useful. In ...
Matthew W Johnson,Roland R Griffiths
Matthew W Johnson
Gamma-hydroxybutyric acid (GHB; sodium oxybate) is approved for narcolepsy symptom treatment, and it is also abused. This study compared the participant-rated, observer-rated effects, motor/cognitive, physiological, and reinforcing effects ...
Comparative Study
Experimental and clinical psychopharmacology. 2013 Apr;21(2):112-123. DOI:10.1037/a0031692 2013
Effects of a 10-day oxytocin trial in older adults on health and well-being [0.03%]
oxytocin在老年人中的应用效果
Jorge A Barraza,Naomi S Grewal,Susan Ropacki et al.
Jorge A Barraza et al.
The neuropeptide oxytocin (OT) modulates functioning of the hypothalamic-pituitary-adrenal (HPA) axis and regulates a range of social processes. Clinical studies have used intranasal OT administration to treat symptoms arising from a number...
Randomized Controlled Trial
Experimental and clinical psychopharmacology. 2013 Apr;21(2):85-92. DOI:10.1037/a0031581 2013
A comprehensive examination of delay discounting in a clinical sample of Cannabis-dependent military veterans making a self-guided quit attempt [0.03%]
对自引导式戒断的依赖大麻的军事退伍军人延迟折扣的全面检查
Adrienne J Heinz,Erica N Peters,Matthew T Boden et al.
Adrienne J Heinz et al.
Delay discounting (DD), an index of impulsivity, reflects individuals' preference for smaller immediate rewards to larger delayed rewards. The current study examined (a) relations between DD and quantity, frequency, and severity of Cannabis...