Nondestructive 3D Pathology with Light-Sheet Fluorescence Microscopy for Translational Research and Clinical Assays [0.03%]
用于转化研究和临床检验的非破坏性三维病理光片荧光显微镜技术
Jonathan T C Liu,Adam K Glaser,Chetan Poudel et al.
Jonathan T C Liu et al.
In recent years, there has been a revived appreciation for the importance of spatial context and morphological phenotypes for both understanding disease progression and guiding treatment decisions. Compared with conventional 2D histopatholo...
Bailey L Bowser,Renã A S Robinson
Bailey L Bowser
The identification of thousands of proteins and their relative levels of expression has furthered understanding of biological processes and disease and stimulated new systems biology hypotheses. Quantitative proteomics workflows that rely o...
Saliva Diagnostics [0.03%]
saliva诊断学
Taichiro Nonaka,David T W Wong
Taichiro Nonaka
Cancer remains one of the leading causes of death, and early detection of this disease is crucial for increasing survival rates. Although cancer can be diagnosed following tissue biopsy, the biopsy procedure is invasive; liquid biopsy provi...
Samantha M Grist,Kevin L Bennewith,Karen C Cheung
Samantha M Grist
Oxygen plays a fundamental role in respiration and metabolism, and quantifying oxygen levels is essential in many environmental, industrial, and research settings. Microdevices facilitate the study of dynamic, oxygen-dependent effects in re...
Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation [0.03%]
神经肽的质谱测定：从鉴定到定量
Eduardo A De La Toba,Sara E Bell,Elena V Romanova et al.
Eduardo A De La Toba et al.
Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are different...
Ryan E Leighton,Ariel M Alperstein,Renee R Frontiera
Ryan E Leighton
Biological and material samples contain nanoscale heterogeneities that are unresolvable with conventional microscopy techniques. Super-resolution fluorescence methods can break the optical diffraction limit to observe these features, but th...
Angelika B Harbauer,Annika Schneider,Dirk Wohlleber
Angelika B Harbauer
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within dif...
Kenneth Marshall Seaton,Morgan Leigh Cable,Amanda Michelle Stockton
Kenneth Marshall Seaton
One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in sit...
W Russ Algar,Katherine D Krause
W Russ Algar
Förster resonance energy transfer (FRET) is a widely used fluorescence-based sensing mechanism. To date, most implementations of FRET sensors have relied on a discrete donor-acceptor pair for detection of each analytical target. FRET netwo...
Quantitative Stimulated Raman Scattering Microscopy: Promises and Pitfalls [0.03%]
定量刺激拉曼散射显微镜：希望与挑战
Bryce Manifold,Dan Fu
Bryce Manifold
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a powerful chemical imaging tool that shows promise in numerous biological and biomedical applications. The spectroscopic capability of SRS enables ident...