In Situ Electrochemical Atomic Force Microscopy: From Interfaces to Interphases [0.03%]
原位电化学原子力显微术：从界面到相界
Wei-Wei Wang,Hao Yan,Yu Gu et al.
Wei-Wei Wang et al.
The electrochemical interface formed between an electrode and an electrolyte significantly affects the rate and mechanism of the electrode reaction through its structure and properties, which vary across the interface. The scope of the inte...
Alba Espargaró,Irene Álvarez-Berbel,Maria Antònia Busquets et al.
Alba Espargaró et al.
Amyloid-related diseases, such as Alzheimer's and Parkinson's disease, are devastating conditions caused by the accumulation of abnormal protein aggregates known as amyloid fibrils. While assays involving animal models are essential for und...
Kathryn J Vannoy,Myles Quinn Edwards,Christophe Renault et al.
Kathryn J Vannoy et al.
Analytical techniques operating at the nanoscale introduce confinement as a tool at our disposal. This review delves into the phenomenon of accelerated reactivity within micro- and nanodroplets. A decade of accelerated reactivity observatio...
Madeline E Colley,Allison B Esselman,Claire F Scott et al.
Madeline E Colley et al.
Imaging mass spectrometry (IMS) enables highly multiplexed, untargeted tissue mapping for a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges persist in molecular specificity, which is the ability ...
Cassandra Herbert,Satenik Valesyan,Jennifer Kist et al.
Cassandra Herbert et al.
Ribonucleic acids (RNAs) are key biomolecules responsible for the transmission of genetic information, the synthesis of proteins, and modulation of many biochemical processes. They are also often the key components of viruses. Synthetic RNA...
Toward Unrivaled Chromatographic Resolving Power in Proteomics: Design and Development of Comprehensive Spatial Three-Dimensional Liquid-Phase Separation Technology [0.03%]
迈向蛋白质组学中无与伦比的色谱分辨率：综合性空间三维液相分离技术的设计与开发
Sebastiaan Eeltink,Jelle De Vos,Gert Desmet
Sebastiaan Eeltink
Spatial comprehensive three-dimensional chromatography (3D-LC) offers an innovative approach to achieve unprecedented resolving power in terms of peak capacity and sample throughput. This advanced technique separates components within a 3D ...
Label-Free Optical Technologies to Enhance Noninvasive Endoscopic Imaging of Early-Stage Cancers [0.03%]
无标签光学技术提高非侵入性内窥镜成像早期癌症的能力
Shuang Chang,Halina Krzyzanowska,Audrey K Bowden
Shuang Chang
White light endoscopic imaging allows for the examination of internal human organs and is essential in the detection and treatment of early-stage cancers. To facilitate diagnosis of precancerous changes and early-stage cancers, label-free o...
Maximizing Analytical Performance in Biomolecular Discovery with LC-MS: Focus on Psychiatric Disorders [0.03%]
液质联用(LC-MS)在生物分子发现中对精神障碍的分析性能最大化
Bradley J Smith,Paul C Guest,Daniel Martins-de-Souza
Bradley J Smith
In this review, we discuss the cutting-edge developments in mass spectrometry proteomics and metabolomics that have brought improvements for the identification of new disease-based biomarkers. A special focus is placed on psychiatric disord...
Emerging Areas in Undergraduate Analytical Chemistry Education: Microfluidics, Microcontrollers, and Chemometrics [0.03%]
本科分析化学教育中的新兴领域：微流控、微控制器和化学计量学
Amber M Hupp,Michelle L Kovarik,Daniel A McCurry
Amber M Hupp
Analytical chemistry is a fast-paced field with frequent introduction of new techniques via research labs; however, incorporation of new techniques into academic curricula lags their adoption in research and industry. This review describes ...
Raman and Surface-Enhanced Raman Scattering Detection in Flowing Solutions for Complex Mixture Analysis [0.03%]
流动溶液中的拉曼和表面增强拉曼散射检测在复杂混合物分析中的应用
Monika Poonia,Courtney J Morder,Hannah C Schorr et al.
Monika Poonia et al.
Raman scattering provides a chemical-specific and label-free method for identifying and quantifying molecules in flowing solutions. This review provides a comprehensive examination of the application of Raman spectroscopy and surface-enhanc...