Michael B Pomfret,Jeffrey C Owrutsky,Robert A Walker
Michael B Pomfret
Thermal imaging and vibrational spectroscopy have become important tools for examining the physical and chemical changes that occur in real time in solid-oxide fuel cells (SOFCs). Imaging techniques can resolve temperature differences as fi...
James W Jorgenson
James W Jorgenson
Ultrahigh-pressure liquid chromatography (UHPLC) is a method of liquid chromatography utilizing sub-2-microm particles packed into capillary columns 25 to 100 cm long. Columns of this length packed with particles this fine require operation...
Single-molecule DNA analysis [0.03%]
单分子DNA分析
J William Efcavitch,John F Thompson
J William Efcavitch
The ability to detect single molecules of DNA or RNA has led to an extremely rich area of exploration of the single most important biomolecule in nature. In cases in which the nucleic acid molecules are tethered to a solid support, confined...
Michael D Fayer,Nancy E Levinger
Michael D Fayer
The properties of water depend on its extended hydrogen bond network and the continual picosecond-time scale structural evolution of the network. Water molecules in confined environments with pools a few nanometers in diameter or at interfa...
Evaluation of DNA/Ligand interactions by electrospray ionization mass spectrometry [0.03%]
采用静电喷雾电离质谱技术评价DNA/配体相互作用
Jennifer S Brodbelt
Jennifer S Brodbelt
Electrospray ionization mass spectrometry (ESI-MS) has enabled the detection and characterization of DNA/ligand complexes, including evaluation of both relative binding affinities and selectivities of DNA-interactive ligands. The noncovalen...
Min-Zong Huang,Cheng-Hui Yuan,Sy-Chyi Cheng et al.
Min-Zong Huang et al.
Mass spectrometric ionization methods that operate under ambient conditions and require minimal or no sample pretreatment have attracted much attention in such fields as biomedicine, food safety, antiterrorism, pharmaceuticals, and environm...
Integrated microreactors for reaction automation: new approaches to reaction development [0.03%]
集成式微反应器实现反应自动化：新的反应开发方法
Jonathan P McMullen,Klavs F Jensen
Jonathan P McMullen
Applications of microsystems (microreactors) in continuous-flow chemistry have expanded rapidly over the past two decades, with numerous reports of higher conversions and yields compared to conventional batch benchtop equipment. Synthesis a...
Royce W Murray
Royce W Murray
The author recounts progress observed in analytical chemistry (the discipline) from the vantage point of a 20-year editor of Analytical Chemistry (the journal). The recounting draws liberally from the journal's monthly editorials. A complet...
Kelly L Adams,Maja Puchades,Andrew G Ewing
Kelly L Adams
This article reviews recent work involving electrochemical methods for in vitro analysis of biomolecules, with an emphasis on detection and manipulation at and of single cells and cultures of cells. The techniques discussed include constant...
Yong-Eun Koo Lee,Ron Smith,Raoul Kopelman
Yong-Eun Koo Lee
Nanoparticle sensors have been developed for real-time imaging and dynamic monitoring, both in live cells and in vivo, of molecular and ionic components, constructs, forces, and dynamics observed during biological, chemical, and physical pr...