Harold J W Zandvliet,Arie van Houselt
Harold J W Zandvliet
The scanning tunneling microscope (STM) has revolutionized our ability to explore and manipulate atomic-scale solid surfaces. In addition to its unparalleled spatial power, the STM can study dynamical processes, such as molecular conformati...
Liquid-phase and evanescent-wave cavity ring-down spectroscopy in analytical chemistry [0.03%]
液相和腔衰荡消光光谱在分析化学中的应用
L van der Sneppen,F Ariese,C Gooijer et al.
L van der Sneppen et al.
Due to its simplicity, versatility, and straightforward interpretation into absolute concentrations, molecular absorbance detection is widely used in liquid-phase analytical chemistry. Because this method is inherently less sensitive than z...
John B Fenn
John B Fenn
Editor's Note: Every year, the Editorial Committee of each Annual Reviews series asks an internationally distinguished researcher to prepare a prefatory article for the volume being planned. It was an easy choice for us to seek a contributi...
Stephen J Blanksby,Todd W Mitchell
Stephen J Blanksby
Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification and quantification of molecular lipids in complex matrices. Although there are s...
Udara Dharmasiri,Małgorzata A Witek,Andre A Adams et al.
Udara Dharmasiri et al.
Efficient selection and enumeration of low-abundance biological cells are highly important in a variety of applications. For example, the clinical utility of circulating tumor cells (CTCs) in peripheral blood is recognized as a viable bioma...
Rotationally induced hydrodynamics: fundamentals and applications to high-speed bioassays [0.03%]
旋转引起的流体动力学：基础理论及其在高速生物检测中的应用
Gufeng Wang,Jeremy D Driskell,April A Hill et al.
Gufeng Wang et al.
Bioassays are indispensable tools in areas ranging from fundamental life science research to clinical practice. Improving assay speed and levels of detection will have a profound impact in all of these areas. We recently developed a rapid, ...
Gas-phase chemistry of multiply charged bioions in analytical mass spectrometry [0.03%]
气相多重电荷生物离子的化学性质在分析型质谱中的作用
Teng-Yi Huang,Scott A McLuckey
Teng-Yi Huang
Ion chemistry has long played an important role in molecular mass spectrometry (MS), as it is central to the use of MS as a structural characterization tool. With the advent of ionization methods capable of producing gaseous ions from large...
Chiral separations [0.03%]
拆分的手性异构体
A M Stalcup
A M Stalcup
The main goal of this review is to provide a brief overview of chiral separations to researchers who are versed in the area of analytical separations but unfamiliar with chiral separations. To researchers who are not familiar with this area...
Victor I Claessen,Hans Engelkamp,Peter C M Christianen et al.
Victor I Claessen et al.
The potential of single-enzyme studies to unravel the complex energy landscape of these polymeric catalysts is the next critical step in enzymology. From its inception in Rotman's emulsion experiments in the 1960s, the field of single-molec...
Albert Schulte,Michaela Nebel,Wolfgang Schuhmann
Albert Schulte
This article reviews recent work involving the application of scanning electrochemical microscopy (SECM) to the study of individual cultured living cells, with an emphasis on topographical and functional imaging of neuronal and secretory ce...