Nanoscale control and manipulation of molecular transport in chemical analysis [0.03%]
化学分析中分子传输的纳米调控与操作
Paul W Bohn
Paul W Bohn
The ability to understand and control molecular transport is critical to numerous chemical measurement strategies, especially as they apply to mass-limited samples in nanometer-scale structures. The characteristics of nanoscale structures a...
Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality [0.03%]
基于质谱的生物标志物发现：迈向个性化的全球蛋白质组指数
Adam M Hawkridge,David C Muddiman
Adam M Hawkridge
Biomarker discovery and proteomics have become synonymous with mass spectrometry in recent years. Although this conflation is an injustice to the many essential biomolecular techniques widely used in biomarker-discovery platforms, it unders...
Eun Jeong Cho,Joo-Woon Lee,Andrew D Ellington
Eun Jeong Cho
Aptamers are ligand-binding nucleic acids whose affinities and selectivities can rival those of antibodies. They have been adapted to analytical applications not only as alternatives to antibodies, but as unique reagents in their own right....
Tim Conze,Alysha Shetye,Yuki Tanaka et al.
Tim Conze et al.
Analytical reactions in which short DNA strands are used in combination with DNA ligases have proven useful for measuring, decoding, and locating most classes of macromolecules. Given the need to accumulate large amounts of precise molecula...
Miniature mass spectrometers [0.03%]
小型质谱仪
Zheng Ouyang,R Graham Cooks
Zheng Ouyang
We discuss miniaturization in mass spectrometry in terms of the mass analyzer, the mass spectrometer, and the total analytical system. Mass analyzer miniaturization has focused on ion traps. Decreases in mass analyzer size facilitate reduct...
Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles [0.03%]
单个生物分子和生物颗粒的超高质量质谱分析
Huan-Cheng Chang
Huan-Cheng Chang
Since the advent of soft ionization methods, mass spectrometry (MS) has found widespread application in the life sciences. Mass is now known to be a critical parameter for characterization of biomolecules and their complexes; it is also a u...
Renee J Soukup-Hein,Molly M Warnke,Daniel W Armstrong
Renee J Soukup-Hein
The role of ionic liquids (ILs) in analytical chemistry is increasing substantially every year. A decade ago there were but a handful of papers in this area of research that were considered curiosities at best. Today, those publications are...
Analytical chemistry with silica sol-gels: traditional routes to new materials for chemical analysis [0.03%]
硅溶胶-凝胶分析化学：从传统合成到用于化学分析的新材料
Alain Walcarius,Maryanne M Collinson
Alain Walcarius
The versatility of sol-gel chemistry enables us to generate a wide range of silica and organosilica materials with controlled structure, composition, morphology and porosity. These materials' hosting and recognition properties, as well as t...
Shigeru Terabe
Shigeru Terabe
Micellar electrokinetic chromatography (MEKC), a separation mode of capillary electrophoresis (CE), has enabled the separation of electrically neutral analytes. MEKC can be performed by adding an ionic micelle to the running solution of CE ...
Kyo Seon Hwang,Sang-Myung Lee,Sang Kyung Kim et al.
Kyo Seon Hwang et al.
Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically im...