Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation [0.03%]
十年创新后的液相色谱/质谱技术在药物发现中的应用
Bradley L Ackermann,Michael J Berna,James A Eckstein et al.
Bradley L Ackermann et al.
Current drug discovery involves a highly iterative process pertaining to three core disciplines: biology, chemistry, and drug disposition. For most pharmaceutical companies the path to a drug candidate comprises similar stages: target ident...
Brian C Bohrer,Samuel I Merenbloom,Stormy L Koeniger et al.
Brian C Bohrer et al.
Although nonnative protein conformations, including intermediates along the folding pathway and kinetically trapped misfolded species that disfavor the native state, are rarely isolated in the solution phase, they are often stable in the ga...
Joshua M Stillahn,Kristina J Trevino,Ellen R Fisher
Joshua M Stillahn
This review focuses on the use of diagnostic tools to examine plasma processing chemistry, primarily plasma species energetics, dynamics, and molecule-surface reactions. We describe the use of optical diagnostic tools, mass spectrometry, an...
Theodore P Snow,Veronica M Bierbaum
Theodore P Snow
We present an overview of the interstellar medium, including physical and chemical conditions, spectroscopic observations, and current challenges in characterizing interstellar chemistry. Laboratory studies of ion-atom reactions, including ...
Laura M Borland,Sumith Kottegoda,K Scott Phillips et al.
Laura M Borland et al.
Chemical analysis of single cells requires methods for quickly and quantitatively detecting a diverse array of analytes from extremely small volumes (femtoliters to nanoliters) with very high sensitivity and selectivity. Microelectrophoreti...
Daniella Cohen,Jane A Dickerson,Colin D Whitmore et al.
Daniella Cohen et al.
Cytometry deals with the analysis of the composition of single cells. Flow and image cytometry employ antibody-based stains to characterize a handful of components in single cells. Chemical cytometry, in contrast, employs a suite of powerfu...
Novel detection schemes of nuclear magnetic resonance and magnetic resonance imaging: applications from analytical chemistry to molecular sensors [0.03%]
新颖的核磁共振及磁共振成像检测方法：从分析化学到分子传感的应用
Elad Harel,Leif Schröder,Shoujun Xu
Elad Harel
Nuclear magnetic resonance (NMR) is a well-established analytical technique in chemistry. The ability to precisely control the nuclear spin interactions that give rise to the NMR phenomenon has led to revolutionary advances in fields as div...
Shigeru Amemiya,Allen J Bard,Fu-Ren F Fan et al.
Shigeru Amemiya et al.
This review describes work done in scanning electrochemical microscopy (SECM) since 2000 with an emphasis on new applications and important trends, such as nanometer-sized tips. SECM has been adapted to investigate charge transport across l...
Plamen A Demirev,Catherine Fenselau
Plamen A Demirev
Advances in instrumentation, proteomics, and bioinformatics have contributed to the successful applications of mass spectrometry (MS) for detection, identification, and classification of microorganisms. These MS applications are based on th...
Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics [0.03%]
代谢组学和代谢物组学中用于信息恢复的分光镜技术和统计分析技术
John C Lindon,Jeremy K Nicholson
John C Lindon
Methods for generating and interpreting metabolic profiles based on nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and chemometric analysis methods are summarized and the relative strengths and weaknesses of NMR and ...