Resonance-enhanced multiphoton ionization mass spectrometry (REMPI-MS): applications for process analysis [0.03%]
共振增强多光子电离质谱(REMPI-MS)在过程分析中的应用
Thorsten Streibel,Ralf Zimmermann
Thorsten Streibel
Process analysis is an emerging discipline in analytical sciences that poses special requirements on analytical techniques, especially when conducted in an online manner. Mass spectrometric methods seem exceedingly suitable for this task, p...
Point-of-care platforms [0.03%]
现场检测平台技术
Günter Gauglitz
Günter Gauglitz
Point-of-care applications are gaining increasing interest in clinical diagnostics and emergency applications. Biosensors are used to monitor the biomolecular interaction process between a disease biomarker and a recognition element such as...
Ambient femtosecond laser vaporization and nanosecond laser desorption electrospray ionization mass spectrometry [0.03%]
飞秒激光蒸发和纳秒激光解吸电喷雾质谱法
Paul Flanigan,Robert Levis
Paul Flanigan
Recent investigations of ambient laser-based transfer of molecules into the gas phase for subsequent mass spectral analysis have undergone a renaissance resulting from the separation of vaporization and ionization events. Here, we seek to p...
Patrick Giraudeau,Lucio Frydman
Patrick Giraudeau
Two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy is widely used in chemical and biochemical analyses. Multidimensional NMR is also witnessing increased use in quantitative and metabolic screening applications. Conventional 2...
Analytical approaches for size and mass analysis of large protein assemblies [0.03%]
大型蛋白质复合物尺寸和质量分析的分析方法
Joost Snijder,Albert J R Heck
Joost Snijder
Analysis of the size and mass of nanoparticles, whether they are natural biomacromolecular or synthetic supramolecular assemblies, is an important step in the characterization of such molecular species. In recent years, electrospray ionizat...
Biologically inspired nanofibers for use in translational bioanalytical systems [0.03%]
仿生纳米纤维在转化生物分析系统中的应用研究
Lauren Matlock-Colangelo,Antje J Baeumner
Lauren Matlock-Colangelo
Electrospun nanofiber mats are characterized by large surface-area-to-volume ratios, high porosities, and a diverse range of chemical functionalities. Although electrospun nanofibers have been used successfully to increase the immobilizatio...
Erica M Forsberg,Clémence Sicard,John D Brennan
Erica M Forsberg
In the past 30 years, there has been a significant growth in the use of solid-phase assays in the area of drug discovery, with a range of new assays being used for both soluble and membrane-bound targets. In this review, we provide some bas...
Klaus Mathwig,Thijs J Aartsma,Gerard W Canters et al.
Klaus Mathwig et al.
The development of experiments capable of probing individual molecules has led to major breakthroughs in fields ranging from molecular electronics to biophysics, allowing direct tests of knowledge derived from macroscopic measurements and e...
M Ariel Geer,Michael C Fitzgerald
M Ariel Geer
Over the past 15 years, a series of energetics-based techniques have been developed for the thermodynamic analysis of protein folding and stability. These techniques include Stability of Unpurified Proteins from Rates of amide H/D Exchange ...
Il-Hoon Cho,Adarsh D Radadia,Khashayar Farrokhzad et al.
Il-Hoon Cho et al.
Despite continuing research efforts, timely and simple pathogen detection with a high degree of sensitivity and specificity remains an elusive goal. Given the recent explosion of sensor technologies, significant strides have been made in ad...