Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses [0.03%]
结合前处理分离、离子淌度和质谱技术以增强多维生物及环境分析能力
Xueyun Zheng,Roza Wojcik,Xing Zhang et al.
Xueyun Zheng et al.
Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. Though IMS alone is useful, its coupling with mass spectrometry (MS) and front-end separations is extremely beneficial f...
Timothy K Toby,Luca Fornelli,Neil L Kelleher
Timothy K Toby
From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 years, mass spectrometry (MS) has become a powerf...
Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge [0.03%]
质谱中的高级多维分离：应对大数据洪流
Jody C May,John A McLean
Jody C May
Hybrid analytical instrumentation constructed around mass spectrometry (MS) is becoming the preferred technique for addressing many grand challenges in science and medicine. From the omics sciences to drug discovery and synthetic biology, m...
Recent Progress in Monolithic Silica Columns for High-Speed and High-Selectivity Separations [0.03%]
高速高选择性分离整体硅胶柱研究新进展
Tohru Ikegami,Nobuo Tanaka
Tohru Ikegami
Monolithic silica columns have greater (through-pore size)/(skeleton size) ratios than particulate columns and fixed support structures in a column for chemical modification, resulting in high-efficiency columns and stationary phases. This ...
Adrian M Schrell,Nikita Mukhitov,Lian Yi et al.
Adrian M Schrell et al.
The release of chemical information from cells and tissues holds the key to understanding cellular behavior and dysfunction. The development of methodologies that can measure cellular secretion in a time-dependent fashion is therefore essen...
Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications [0.03%]
糖链芯片技术及其应用进展
Andreas Geissner,Peter H Seeberger
Andreas Geissner
A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthink...
Alexander Laskin,Mary K Gilles,Daniel A Knopf et al.
Alexander Laskin et al.
This article presents an overview of recent advances in field and laboratory studies of atmospheric particles formed in processes of environmental air-surface interactions. The overarching goal of these studies is to advance predictive unde...
In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy [0.03%]
相干拉曼散射显微镜的原位和在体分子分析
Chien-Sheng Liao,Ji-Xin Cheng
Chien-Sheng Liao
Coherent Raman scattering (CRS) microscopy is a high-speed vibrational imaging platform with the ability to visualize the chemical content of a living specimen by using molecular vibrational fingerprints. We review technical advances and bi...
Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry [0.03%]
液相样品解吸电喷雾离子化质谱法的发展与应用
Qiuling Zheng,Hao Chen
Qiuling Zheng
Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fa...
Mass Spectrometry as a Preparative Tool for the Surface Science of Large Molecules [0.03%]
大规模分子表面科学准备工具中的质谱法
Stephan Rauschenbach,Markus Ternes,Ludger Harnau et al.
Stephan Rauschenbach et al.
Measuring and understanding the complexity that arises when nanostructures interact with their environment are one of the major current challenges of nanoscale science and technology. High-resolution microscopy methods such as scanning prob...