Bioanalytical Measurements Enabled by Surface-Enhanced Raman Scattering (SERS) Probes [0.03%]
表面增强拉曼散射(SERS)探针的生物分析测量技术
Lauren E Jamieson,Steven M Asiala,Kirsten Gracie et al.
Lauren E Jamieson et al.
Since its discovery in 1974, surface-enhanced Raman scattering (SERS) has gained momentum as an important tool in analytical chemistry. SERS is used widely for analysis of biological samples, ranging from in vitro cell culture models, to ex...
Siddarth Rawal,Yu-Ping Yang,Richard Cote et al.
Siddarth Rawal et al.
Circulating tumor cells (CTCs) are shed from the primary tumor into the circulatory system and act as seeds that initiate cancer metastasis to distant sites. CTC enumeration has been shown to have a significant prognostic value as a surroga...
Jason J Amsden,Michael E Gehm,Zachary E Russell et al.
Jason J Amsden et al.
The use of coded apertures in mass spectrometry can break the trade-off between throughput and resolution that has historically plagued conventional instruments. Despite their very early stage of development, coded apertures have been shown...
Liang Yuan,Nongjian Tao,Wei Wang
Liang Yuan
Electrochemical impedance spectroscopy (EIS) measures the frequency spectrum of an electrochemical interface to resist an alternating current. This method allows label-free and noninvasive studies on interfacial adsorption and molecular int...
Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells [0.03%]
磁共振光谱在活细胞中评估大分子结构和功能的工具
Conggang Li,Jiajing Zhao,Kai Cheng et al.
Conggang Li et al.
Investigating the structure, modification, interaction, and function of biomolecules in their native cellular environment leads to physiologically relevant knowledge about their mechanisms, which will benefit drug discovery and design. In r...
Sizing Up Protein-Ligand Complexes: The Rise of Structural Mass Spectrometry Approaches in the Pharmaceutical Sciences [0.03%]
结构质量测定在药物科学中的应用及结构性质作用复合物的分析方法的发展
Joseph D Eschweiler,Richard Kerr,Jessica Rabuck-Gibbons et al.
Joseph D Eschweiler et al.
Capturing the dynamic interplay between proteins and their myriad interaction partners is critically important for advancing our understanding of almost every biochemical process and human disease. The importance of this general area has sp...
Limor Cohen,David R Walt
Limor Cohen
The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement of analytes of interest into ultrasmall containers have greatly enhanced the sensi...
Angela R Wu,Jianbin Wang,Aaron M Streets et al.
Angela R Wu et al.
Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that woul...
Raman Imaging in Cell Membranes, Lipid-Rich Organelles, and Lipid Bilayers [0.03%]
细胞膜、富含脂质的细胞器和脂质双层中的拉曼成像技术
Aleem Syed,Emily A Smith
Aleem Syed
Raman-based optical imaging is a promising analytical tool for noninvasive, label-free chemical imaging of lipid bilayers and cellular membranes. Imaging using spontaneous Raman scattering suffers from a low intensity that hinders its use i...
Renee J Tran,Krystal L Sly,John C Conboy
Renee J Tran
Surface second harmonic generation (SHG) is a coherent, nonlinear optical technique that is well suited for investigations of biomolecular interactions at interfaces. SHG is surface specific due to the intrinsic symmetry constraints on the ...