Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics [0.03%]
基于质谱的代谢组学当前挑战及最新进展
Stephanie L Collins,Imhoi Koo,Jeffrey M Peters et al.
Stephanie L Collins et al.
High-resolution mass spectrometry (MS) has advanced the study of metabolism in living systems by allowing many metabolites to be measured in a single experiment. Although improvements in mass detector sensitivity have facilitated the detect...
Kenneth R Wehmeyer,Ryan J White,Peter T Kissinger et al.
Kenneth R Wehmeyer et al.
The advent of electrochemical affinity assays and sensors evolved from pioneering efforts in the 1970s to broaden the field of analytes accessible to the selective and sensitive performance of electrochemical detection. The foundation of el...
Bo Cheng,Qi Tang,Che Zhang et al.
Bo Cheng et al.
As one of the major types of biomacromolecules in the cell, glycans play essential functional roles in various biological processes. Compared with proteins and nucleic acids, the analysis of glycans in situ has been more challenging. Herein...
David Klenerman,Yuri Korchev,Pavel Novak et al.
David Klenerman et al.
The reduction in ion current as a fine pipette approaches a cell surface allows the cell surface topography to be imaged, with nanoscale resolution, without contact with the delicate cell surface. A variety of different methods have been de...
Real-Time Visualization and Monitoring of Physiological Dynamics by Aggregation-Induced Emission Luminogens (AIEgens) [0.03%]
聚集诱导发光分子(AIEgen)的生理动态实时可视化与监测技术
Xuewen He,Jacky W Y Lam,Ryan T K Kwok et al.
Xuewen He et al.
Physiological dynamics in living cells and tissues are crucial for maintenance and regulation of their normal activities and functionalities. Tiny fluctuations in physiological microenvironments can leverage significant influences on cell g...
Goran W Tumbic,Md Yeathad Hossan,Megan C Thielges
Goran W Tumbic
Proteins function as ensembles of interconverting structures. The motions span from picosecond bond rotations to millisecond and longer subunit displacements. Characterization of functional dynamics on all spatial and temporal scales remain...
Recent Progress in the Analytical Chemistry of Champagne and Sparkling Wines [0.03%]
香槟和起泡酒分析化学的最新进展
Gérard Liger-Belair,Clara Cilindre
Gérard Liger-Belair
The strong interplay between the various parameters at play in a bottle and in a glass of champagne or sparkling wine has been the subject of study for about two decades. After a brief overview of the history of champagne and sparkling wine...
Nan Shi,Md Mohibullah,Christopher J Easley
Nan Shi
Droplet-based microfluidics has emerged as an important subfield within the microfluidic and general analytical communities. Indeed, several unique applications such as digital assay readout and single-cell sequencing now have commercial sy...
Tobias Weidner,David G Castner
Tobias Weidner
Proteins at surfaces and interfaces play important roles in the function and performance of materials in applications ranging from diagnostic assays to biomedical devices. To improve the performance of these materials, detailed molecular st...
Suji Lee,Kavyasree Chintalapudi,Abraham K Badu-Tawiah
Suji Lee
Early disease diagnosis is necessary to enable timely interventions. Implementation of this vital task in the developing world is challenging owing to limited resources. Diagnostic approaches developed for resource-limited settings have oft...