Caught in the Act: Intercalated Duct Lesion Associated with Adenoid Cystic Carcinoma Harboring a MYBL1::NFIB Fusion [0.03%]
caught in the act：MYBL1::NFIB融合阳性的腺样囊性癌相关的闰管样病变
André Lametti,Seungwon Kim,Raja R Seethala
André Lametti
Intercalated duct lesions (IDLs) are putative precursors notably associated with epithelial myoepithelial carcinoma and basal cell adenoma. We report the novel transition of IDL to adenoid cystic carcinoma (AdCC) in the parotid gland of a 3...
A Genomic and Epigenetic Comparative Study of Low-grade Biphenotypic Sinonasal Sarcoma with Metachronous and Synchronous High-grade Rhabdomyosarcomatous Transformation [0.03%]
低级别双表型鼻腔窦肉瘤伴异时性和同步高级别横纹肌肉瘤样转化的基因组和表观遗传学比较研究
Rayan M Sibira,Constance Chen,Felipe D&#x; Almeida Costa et al.
Rayan M Sibira et al.
Background: Biphenotypic sinonasal sarcoma (BSNS) is usually histologically distinguishable in its conventional form based on morphology and ancillary studies. However, a subset of BSNS loses characteristic histologic fea...
Comparative Study
Head and neck pathology. 2026 May 25;20(1):49. DOI:10.1007/s12105-026-01923-1 2026
Digital Pathology in Head and Neck Squamous Cell Carcinoma: Translational Advances and Clinical Integration for Pathologists, Oncologists, and Surgeons [0.03%]
数字化病理在头颈部鳞状细胞癌中的转化进展和临床整合——病理学家、肿瘤学家和外科医生的视角
Sholem Hack,Daor Hayu,Jacob E Karni et al.
Sholem Hack et al.
Purpose: Artificial intelligence (AI)-enabled digital pathology has advanced rapidly in head and neck squamous cell carcinoma (HNSCC), but its readiness for clinical implementation remains uncertain. This review evaluates...
Genetic Landscape of Oral Carcinoma Cuniculatum and its Histological Mimics [0.03%]
乳头状口腔癌及其组织学模仿的遗传景观分析
Sawako Ono,Yuki Fukawa,Katsutoshi Hirose et al.
Sawako Ono et al.
Purpose: Oral carcinoma cuniculatum (CC) is a rare variant of oral squamous cell carcinoma (OSCC), characterized by a well-differentiated, burrowing invasive pattern and minimal cellular atypia. Its diagnosis is challengi...
Malignant Transformation of a Radiation-Naïve Sinonasal Tract Angiofibroma: Clinicopathologic and Molecular Characterization of an Exceptionally Delayed Transformation [0.03%]
未经放射的鼻窦血管纤维瘤恶性转化：迟发性恶性转化的临床病理和分子特征描述
Shaden N Hamada,Bayan A Alzumaili,Harry P W Kozakewich et al.
Shaden N Hamada et al.
Sinonasal tract angiofibroma (formerly juvenile nasopharyngeal angiofibroma) is a rare benign but locally aggressive vascular tumor that predominantly affects adolescent males. Malignant transformation is exceedingly uncommon and has histor...
HPV-Associated Sarcomatoid (Spindle Cell) Carcinoma of the Base of the Tongue with HRAS and TERT Promoter Mutations [0.03%]
与HRAS和TERT启动子突变有关的舌根部人乳头瘤病毒相关肉瘤样（梭形细胞）癌
Lacey Durham,Lawrence J Jennings,Yash J Patil et al.
Lacey Durham et al.
Background: Sarcomatoid carcinoma is an aggressive and uncommon variant of squamous cell carcinoma that is rarely encountered in the oropharynx. Distinguishing this entity from true sarcomas or reactive stromal proliferat...
Oropharyngeal Cartilaginous Choristoma Presenting as a Unilateral Mass [0.03%]
咽部软骨异位组织肿瘤作为单侧肿物出现的一例报告
Imran Ajmal,Harishanker Jeyarajan,Melad N Dababneh
Imran Ajmal
Oropharyngeal cartilaginous choristomas are uncommon incidental lesions identified in tonsillectomy specimens. We present an unusual example of a mass-forming cartilaginous choristoma of the palatine tonsil and share its macroscopic and his...
The Role of Molecular Testing in Head and Neck Squamous Cell Carcinoma of Unknown Primary [0.03%]
头颈部未知原发灶鳞状细胞癌的分子检测作用
Irfan Yasin,Jen-Fan Hang,Ying-Hsia Chu
Irfan Yasin
Squamous cell carcinomas of unknown primary (SCCUP), accounting for approximately 5% of head and neck malignancies, present significant clinical challenges in achieving disease control while minimizing therapy-related morbidities in the abs...
Malignant Transformation of Sinonasal Papilloma: Assessment of Clinicopathologic Features, p16 and p53 Expression, Transcriptionally Active HPV Status and Underlying Molecular Alterations [0.03%]
鼻窦乳头状瘤恶变的临床病理特征、p16和p53表达、HPV转录活性及潜在分子异常分析
Sara E Amin,Reiri Sono,Zubaidah I Al-Jumaili et al.
Sara E Amin et al.
Purpose: Sinonasal papilloma (SP) has a recognized potential for malignant transformation, most commonly into squamous cell carcinoma (SCC). Well-established criteria for malignancy are lacking in SP and often depends on ...
Delusions of Gland-eur: Navigating the Morphological Mimicry of and by Salivary Gland Neoplasms [0.03%]
唾液腺肿瘤的形态模仿：垂涎 gland-eur 的妄想
Elan Hahn
Elan Hahn
Background: Salivary gland neoplasms encompass a broad spectrum of morphologic patterns, immunophenotypes, and molecular alterations, and demonstrate overlap with other head and neck tumors and tumors from different lines...