Predictors of ≥15% Weight Reduction and Associated Changes in Cardiometabolic Risk Factors With Tirzepatide in Adults With Type 2 Diabetes in SURPASS 1-4 [0.03%]
SURPASS 1-4研究中 tirzepatide 治疗的成人2型糖尿病患者体重降低≥15%的影响因素及与心血管代谢危险因素变化的相关性
Maciej T Małecki,Rachel L Batterham,Naveed Sattar et al.
Maciej T Małecki et al.
Objective: To identify predictors of body weight (BW) reduction of ≥15% with tirzepatide treatment and to describe associated clinical parameters of participants with type 2 diabetes (T2D) who achieved different categori...
Clinical Trial
Diabetes care. 2023 Dec 1;46(12):2292-2299. DOI:10.2337/dc23-1135 2023
Jean Shin,Yash Patel,Nadine Parker et al.
Jean Shin et al.
Objective: To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved. ...
A Randomized Trial of Closed-Loop Insulin Delivery Postpartum in Type 1 Diabetes [0.03%]
1型糖尿病产后胰岛素封闭环路输送的随机试验
Lois E Donovan,Denice S Feig,Patricia Lemieux et al.
Lois E Donovan et al.
Objective: This study aimed to evaluate the efficacy of closed-loop insulin delivery postpartum. Research design and methods: In this o...
Randomized Controlled Trial
Diabetes care. 2023 Dec 1;46(12):2258-2266. DOI:10.2337/dc23-0882 2023
Dasiglucagon Treatment for Postprandial Hypoglycemia After Gastric Bypass: A Randomized, Double-Blind, Placebo-Controlled Trial [0.03%]
达西格鲁卡尔治疗胃旁路手术后餐后低血糖：随机双盲安慰剂对照试验
Casper K Nielsen,Caroline C Øhrstrøm,Inas J K Houji et al.
Casper K Nielsen et al.
Objective: Postbariatric hypoglycemia affects >50% of individuals who have undergone Roux-en-Y gastric bypass surgery. Despite the often debilitating nature of this complication, existing treatment options are limited and...
Randomized Controlled Trial
Diabetes care. 2023 Dec 1;46(12):2208-2217. DOI:10.2337/dc23-1193 2023
Cocoa Extract Supplementation and Risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial [0.03%]
可可提取物补充剂与2型糖尿病风险的关系：COSMOS随机临床试验
Jie Li,Howard D Sesso,Eunjung Kim et al.
Jie Li et al.
Objective: Observational studies have indicated that cocoa flavanol supplementation may be a promising strategy for type 2 diabetes (T2D) prevention. We aimed to directly evaluate its clinical efficacy in a large randomiz...
Randomized Controlled Trial
Diabetes care. 2023 Dec 1;46(12):2278-2284. DOI:10.2337/dc23-1012 2023
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes [0.03%]
2型糖尿病患者血浆犬尿氨酸通路代谢物与终末期肾病风险的关系
Jian-Jun Liu,Jianhong Ching,Hai Ning Wee et al.
Jian-Jun Liu et al.
Objective: We sought to study the associations between plasma metabolites in the tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease (ESKD) in patients with type 2 diabetes. ...
Association of Continuous Glucose Monitoring Metrics With Pregnancy Outcomes in Patients With Preexisting Diabetes [0.03%]
持续葡萄糖监测指标与既往糖尿病患者的妊娠结局的关系
Ayodeji A Sanusi,Yumo Xue,Claire McIlwraith et al.
Ayodeji A Sanusi et al.
Objective: Continuous glucose monitoring (CGM) improves maternal glycemic control and neonatal outcomes in type 1 diabetes pregnancies compared with self-monitoring of blood glucose. However, CGM targets for pregnancy are...
DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial [0.03%]
ABCG1基因甲基化与饮食干预后长期体脂量和体脂分布的变化：POUNDS Lost试验结果分析
Xiang Li,Xiaojian Shao,Minghao Kou et al.
Xiang Li et al.
Objective: To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight loss interventions with long-term changes in adiposity and body fat...
The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial [0.03%]
针对糖尿病预防的共享决策实施效果：来自糖尿病前期知情决策与教育（PRIDE）试验的24个月和36个月结果
O Kenrik Duru,Carol M Mangione,Norman Turk et al.
O Kenrik Duru et al.
Objective: We conducted a cluster-randomized, shared decision-making (SDM) trial offering lifestyle change, metformin, or both options, to adults at risk for diabetes in a primary care network (n = 20 practices). ...
Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission [0.03%]
通过在DiRECT和DIADEM-I随机临床试验中减重对心血管代谢健康进行血浆蛋白变化预测以实现2型糖尿病缓解
Naveed Sattar,Shahrad Taheri,David P Astling et al.
Naveed Sattar et al.
Objective: To determine the extent to which changes in plasma proteins, previously predictive of cardiometabolic outcomes, predict changes in two diabetes remission trials. ...