Case Report: Oral-Nasal Damage in a Person Using Fentanyl and Xylazine [0.03%]
个例报告：使用芬太尼和赛拉嗪者的口腔-鼻部损伤
Julie Kmiec,Garret Choby
Julie Kmiec
Background: Xylazine, an alpha-2-adrenergic agonist, was added to illicitly manufactured fentanyl within the past decade. Intranasal drug use is common and associated with damage to nasal structures and the palate. There ...
Postmortem Toxicology Positivity for Medications for Opioid Use Disorder in Illinois Unintentional Opioid Overdose Deaths 2019-2024 [0.03%]
2019年至2024年伊利诺伊州意外阿片类药物过量死亡中用于治疗阿片类药物使用障碍的药物的法医毒理学阳性结果分析
Corey Hazekamp,Maryann Mason
Corey Hazekamp
Objectives: Currently, most unintentional opioid overdose deaths (OODs) in the United States are attributed to fentanyl. Buprenorphine and methadone reduce mortality associated with opioid use disorder. Despite the protec...
Opioid Agonist Treatment Use Among First Nation Peoples in Ontario, Canada: A Repeated Cross-sectional Study of Prevalence Trends From 2013 to 2023 [0.03%]
加拿大安大略省第一民族人群的阿片类激动剂治疗使用情况：2013年至2023年的重复横断面研究趋势分析
Nevena Rebić,Shaleesa Ledlie,Bisola Hamzat et al.
Nevena Rebić et al.
Objectives: The opioid toxicity crisis has disproportionately harmed First Nation Peoples, prompting efforts to expand access to opioid agonist therapy (OAT). We described trends in OAT use among this population in Ontari...
Advancing Kratom Science and Regulation: A Comparative Framework With Cannabis [0.03%]
kratom科学研究与监管：与大麻的比较框架
Ynhi T Thomas,Mubeen Iqbal,Chung J Mun et al.
Ynhi T Thomas et al.
Kratom (Mitragyna speciosa) is a psychoactive botanical with a long history of use in Southeast Asia and growing uptake in the United States for its analgesic, stimulant, and mood-altering properties. The evidence base remains limited, and ...
Buprenorphine for the Management of 7-Hydroxymitragynine (7-OH) Use: A Retrospective Case Series [0.03%]
布雷他丁用于7-羟基密 Ke 酐（7-OH）使用者治疗的回顾性病例系列研究
Emma Fenske,Beth Williams,Laurel Hallock-Koppelman et al.
Emma Fenske et al.
Background: Kratom (Mitragyna speciosa) is increasingly used in the United States as a dietary supplement for pain, mood regulation, and opioid withdrawal. Its alkaloids, mitragynine and 7-hydroxymitragynine (7-OH), demon...
Fertility Beliefs and Menstrual Experiences Among Women Entering Opioid Use Disorder Treatment [0.03%]
阿片类药物使用障碍治疗女性患者的生育观念和月经经历调查研究
Jennifer K Bello,Megan Fuerst,Ximena A Levander et al.
Jennifer K Bello et al.
Objectives: Although many people with OUD may believe they are infertile due to chronic opioid use contributing to menstrual irregularities, minimal data exists on how opioid cessation and OUD treatment may impact fertili...
A Narrative Review of the Metabolic Assessment of Patients on Methadone: An Alternative to Pharmacokinetically Blind Prescribing [0.03%]
美沙酮维持治疗患者的代谢评估述评：一种超越盲目关注药动学的处方方式的方法
John J McCarthy,Martin H Leamon
John J McCarthy
With the increase in fentanyl use, methadone remains one of the standards of care for opioid use disorder and may confer some advantages over buprenorphine. Yet the wide range of patient metabolism makes individual prescribing unpredictable...
Utility of Methadone:Metabolite Ratio as Marker of Methadone Metabolism During Methadone Initiation in Pregnancy [0.03%]
妊娠期开始美沙酮治疗时美沙酮∶代谢产物比率作为美沙酮代谢标志物的效用
Rupsa C Boelig,Dennis J Hand,Artem Belyakov et al.
Rupsa C Boelig et al.
Objectives: The methadone:metabolite ratio (MMR) is a laboratory value assessed pre-dose to discriminate between individuals who are rapid or slow metabolizers. It is a proposed alternative to peak:trough serum methadone ...
Development and Validation of an Image-Based Deep Learning Tool for Identification of Xylazine-Associated Wounds [0.03%]
一种基于图像的深度学习工具的开发和验证，用于识别与羟嗪相关的伤口
Pranav Sompalle,Abeed Sarker,Jennifer Love et al.
Pranav Sompalle et al.
Objectives: Accurate identification of xylazine-associated wounds (XAWs) is critical to providing timely and optimal management; however, discerning the etiology of wounds by appearance alone poses a clinical challenge. T...
Association of Emergency Department Buprenorphine Initiation With Subsequent Pharmacotherapy and Outcomes Among Patients With Opioid Use Disorder [0.03%]
急诊科开始使用布施奈菲定对 opioid 使用障碍患者的后续药物治疗和结局的影响
Peter Treitler,Ayse Akincigil,N Andrew Peterson et al.
Peter Treitler et al.
Objectives: To examine trends in emergency department (ED) buprenorphine initiation and evaluate its association with outcomes in the 180 days following discharge. ...