Phylogeographic dynamics of oropouche virus in the Colombian Amazon: Evolutionary insights in a climatic context [0.03%]
哥伦比亚亚马逊地区奥罗普楚病毒的谱系地理动力学：气候背景下的进化见解
Laura S Perez- Restrepo,Jaime Usuga,Alejandro Vasquez et al.
Laura S Perez- Restrepo et al.
Background: In 2024, the largest RT-qPCR-confirmed outbreak of Oropouche virus (OROV) in 70 years occurred in the Brazilian Amazon, raising concerns about transmission and viral evolution in the neighboring Colombian Amaz...
Enhancing risk communication for climate-sensitive neglected tropical diseases in Northern Tanzania: Integrating agropastoral community knowledge and health system strategies [0.03%]
坦桑尼亚北部气候变化敏感的被忽视的热带病风险沟通的加强：整合农牧社区知识和卫生系统策略
Chris G Buse,Emmanuel Sulle,Epiphania Ngowi et al.
Chris G Buse et al.
Tanzania has made significant progress in reducing number of neglected tropical diseases (NTDs) by using education initiatives and mass drug administration (MDA). However, as East Africa's climate continues to change, the extant NTD respons...
Can mass drug administration alone eliminate lymphatic filariasis in areas of Indonesia with zoophilic Brugia malayi? [0.03%]
在以动物嗜好的布鲁线虫为主区域中，单纯的大规模药物治疗能否消除淋巴丝虫病？
Taniawati Supali,Yenny Djuardi,Elisa Iskandar et al.
Taniawati Supali et al.
Belitung district, Indonesia, is endemic for lymphatic filariasis (LF) caused by zoophilic Brugia malayi. The district received 5 rounds of mass drug administration (MDA) with diethycarbamazine and albendazole (DA) between 2006 and 2010 and...
Efficacy and safety outcomes reported in human leptospirosis studies to inform the development of a core outcome and core outcome measurement set: A systematic review [0.03%]
系统综述：人患钩端螺旋体病研究报告的有效性和安全性结果以制定核心成果和核心测量集
Nathaniel Lee,Ines Corcuera Hotz,Chris Smith et al.
Nathaniel Lee et al.
Background: Leptospirosis is a neglected bacterial zoonotic disease of global health importance, disproportionately affecting marginalised communities in tropical and subtropical settings. Current clinical trial evidence ...
A real-time mechanistic framework for early inference of chikungunya transmission and outbreak sizes in mainland France, 2025 [0.03%]
2025年法国本土实时传播辛德毕斯病毒的机制框架及规模早期推断模型
Sandeep Tegar,Dominic P Brass,Bethan V Purse et al.
Sandeep Tegar et al.
In 2025, mainland France experienced an unprecedented chikungunya outbreak in Europe, likely associated with suitable climatic conditions and established presence of Aedes albopictus, the primary European vector of chikungunya virus (CHIKV)...
Synthesis and preliminary evaluation of novel compounds that demonstrate broad host-directed anti-leishmanial activity [0.03%]
一类新型广谱宿主导向抗利什曼病活性化合物的合成与初步评价
Elizabeth G Gurysh,M Shamim Hasan Zahid,Monica M Johnson et al.
Elizabeth G Gurysh et al.
Leishmaniasis, a neglected tropical disease affecting nearly 10% of the global population, suffers from limited therapeutic options and rising drug resistance. To address this, we developed 343 analogs of AR-12, a compound that has previous...
Laboratory diagnosis of loiasis to support individual patient management: A systematic review [0.03%]
劳妙术诊断用于支持利奥妙术的个体患者管理：系统评价
Luzia Veletzky,Marc P Hübner,Cristina Mazzi et al.
Luzia Veletzky et al.
Background: Loiasis is a filarial disease caused by Loa loa, endemic to Central and West Africa. Cases are observed in migrants and occasionally travellers. Its diagnosis may be difficult due to the unspecific clinical pi...
Helminth-infected Mozambican children with malaria have increased anaemia, cytokines and helminth-specific antibodies [0.03%]
莫桑比克患疟疾的寄生虫感染儿童出现贫血、细胞因子和寄生虫特异性抗体增多的现象
Inocência Cuamba,Rebeca Santano,Berta Grau-Pujol et al.
Inocência Cuamba et al.
Owing to their overlapping geographical distribution and the consequent occurrence of coinfections, several studies have evaluated the impact of helminth infections on malaria immune responses and clinical outcomes. However, little has been...
Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury [0.03%]
基于NLRP3/caspase-1/GSDMD途径激活的银环蛇心脏毒素致皮肤组织焦亡损伤作用及机制研究
Nianying Qin,Yiling Zhai,Hongying Cao et al.
Nianying Qin et al.
Background: Cardiotoxin (CTX) from Naja atra venom is a principal virulence factor responsible for progressive local tissue necrosis and systemic inflammation following snakebite. Despite its clinical importance, the mole...
Novel binding partners of the Vacuolar Transporter Chaperone (VTC) complex in Acidocalcisomes of Leishmania tarentolae [0.03%]
利什曼原疟虫酸钙体中的Vacuolar Transporter Chaperone (VTC)复合物的新结合蛋白
Paulina Królak,Orquidea Ribeiro,Bernadette Gehl-Väisänen et al.
Paulina Królak et al.
Acidocalcisomes are evolutionarily conserved acidic organelles that are rich in cations and inorganic phosphate, primarily polyphosphates. In kinetoplastid parasites, acidocalcisomes and their polyphosphate content are essential for osmoreg...