Cryptosporidium parvum protease INS6 plays an important role in parasite proliferation and pathogenicity [0.03%]
隐孢子虫蛋白酶INS6在寄生和致病中起重要作用
Wei He,Zuwei Yang,Jing Wang et al.
Wei He et al.
Background: Cryptosporidium parvum is a common protozoan pathogen responsible for moderate to severe diarrhea in humans and animals. Parasite invasion and egress cause damage to intestinal epithelial cells, which is media...
Molecular docking to homology models of human and Trypanosoma brucei ERK8 that identified ortholog-specific inhibitors [0.03%]
针对人和布氏冈比亚小睡病原虫ERK8的同源模型进行分子对接，发现了特异作用于正交ologue的抑制剂
Matthew Merski,Zachary B Mackey
Matthew Merski
Human African Trypanosomiasis (HAT), also known as sleeping sickness, is a lethal disease caused by two vector-borne parasites: Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. The limited number of antitrypanosomal therapie...
Paratyphoid fever and the genomics of Salmonella enterica serovar Paratyphi A in Taiwan [0.03%]
台湾副伤寒杆菌感染与副伤寒沙门氏菌的基因组学研究
Ying-Shu Liao,Yu-Ping Hong,Bo-Han Chen et al.
Ying-Shu Liao et al.
Background: Salmonella enterica serovar Paratyphi A (S. Paratyphi A) has emerged as a significant global health concern due to the progressive development of antimicrobial resistance and its broader geographic distributio...
Clinical features and mortality risk factors in non-HIV elderly patients with cryptococcal meningitis: A retrospective cohort study from 2013 to 2022 [0.03%]
2013年至2022年非HIV老年新型隐球菌脑膜炎患者临床特征及影响死亡风险的危险因素：队列研究
Xiaofeng Xu,Xiaohong Su,Weipeng Li et al.
Xiaofeng Xu et al.
Background: Cryptococcal meningitis (CM) is a life-threatening fungal infection with increasing incidence among non-HIV (human immunodeficiency virus) elderly populations. However, data on CM in non-HIV elderly patients a...
Early events in dengue virus infection inducing cytokine storm: The dynamic interplay of pattern-recognition receptors, inflammasome activation, and biphasic NF-κB and STAT1-dependent inflammatory responses in human mononuclear phagocytes [0.03%]
诱发登革病毒感染细胞因子风暴的早期事件：模式识别受体、炎性小体激活以及人单核吞噬细胞中NF-κB和STAT1依赖的两相炎症反应的动态相互作用
Juan Felipe Valdés-López,Yordi Sebastián Tamayo-Molina,Geysson J Fernandez et al.
Juan Felipe Valdés-López et al.
A Cytokine storm is critical in severe dengue, significantly contributing to disrupted endothelial integrity, plasma leakage, and haemorrhage manifestations in affected patients. Various reports have demonstrated that mononuclear phagocytes...
Glycosomal ABC transporter 3 (GAT3) deletion enhances the oxidative stress responses and reduces the infectivity of Trypanosoma cruzi [0.03%]
克鲁氏锥虫甘露糖苷体ABC转运蛋白3(GAT3)缺失增强其氧化应激反应并减弱感染性
Davi Alvarenga Lima,Héllida Marina Costa-Silva,Karen Stephanie Sebe Albergaria et al.
Davi Alvarenga Lima et al.
Glycosomes, peroxisome-like organelles in Trypanosoma cruzi, contain enzymes involved in various metabolic processes, including glycolysis. Glycosomal ABC transporters (GATs) play a vital role in maintaining metabolic homeostasis by facilit...
Usability and quality evaluation of the World Health Organization SkinNTDs app among frontline health workers in Cameroon: A mixed methods study [0.03%]
尼日利亚卫生组织皮肤NTDs应用程序在喀麦隆一线卫生工作者中的使用性和质量评估：一种混合方法研究
Henri Claude Moungui,Paul Tonkoung Iyawa,Hugues Nana-Djeunga et al.
Henri Claude Moungui et al.
Background: Originally adapted from a paper-based guide for skin-related neglected tropical diseases (NTDs), version 3.0.0 of the World Health Organization (WHO) SkinNTDs app aims to strengthen disease surveillance and fr...
Richard Olumide Daodu,Ebenezer Awotoro,Jens-Uwe Ulrich et al.
Richard Olumide Daodu et al.
Lassa fever, caused by the Lassa virus (LASV), is a deadly disease characterized by hemorrhages. Annually, it affects approximately 300,000 people in West Africa and causes about 5,000 deaths. It currently has no approved vaccine and is cat...
Orthohantavirus rodent hosts and genotypes in Southern South America: A narrative review [0.03%]
南南美正汉塔病毒啮齿动物宿主及基因型：综述性研究
Natalia Ortiz,Juan Diego Pinotti,Verónica Andreo et al.
Natalia Ortiz et al.
Orthohantaviruses, family Hantaviridae, are zoonotic agents that pose a significant public health threat, particularly in South America, where they cause severe respiratory illnesses in humans. Despite their importance, knowledge gaps remai...
Diversity of Salmonella enterica isolates from urban river and sewage water in Blantyre, Malawi [0.03%]
马拉维布兰太尔市河流和污水中分离的沙门氏菌血清型多样性研究
Jonathan Rigby,Catherine N Wilson,Allan Zuza et al.
Jonathan Rigby et al.
Background: Salmonella enterica encompasses over 2,600 serovars, including several commonly associated with severe infection in humans. Salmonella is a major cause of sepsis in Africa; however, diagnosis requires clinical...