Kelly M King,Koenraad Van Doorslaer
Kelly M King
Phylogenetic analyses allow for inferring a hypothesis about the evolutionary history of a set of homologous molecular sequences. This hypothesis can be used as the basis for further molecular and computational studies. In this unit, we off...
Elizabeth M Anderson,Frank Maldarelli
Elizabeth M Anderson
HIV persists, despite effective antiretroviral therapy, in long-lived cells, posing a major barrier toward a cure. A key step in the HIV replication cycle and a hallmark of the Retroviridae family is the integration of the viral DNA into th...
Human Papillomavirus Integration: Analysis by Molecular Combing and Fiber-FISH [0.03%]
人乳头瘤病毒的整合：通过分子梳理和DNA纤维原位杂交进行分析
Catherine J Redmond,Haiqing Fu,Mirit I Aladjem et al.
Catherine J Redmond et al.
Human papillomaviruses (HPVs) are frequently integrated in HPV-associated cancers. HPV genomes can be integrated in three patterns: A single integrated HPV genome (type I), multiple, tandemly integrated HPV genomes (type II), and multiple, ...
Sandeep Vellanki,Maria Isabel Navarro-Mendoza,Alexis Garcia et al.
Sandeep Vellanki et al.
Mucor circinelloides is a fungus that belongs to the order Mucorales. It grows as mold in the environment and can cause mucormycosis, a potentially fatal infection in immunocompromised patients. M. circinelloides is a biodiesel producer and...
Tanel Punga,Sibel Ciftci,Mats Nilsson et al.
Tanel Punga et al.
Infection by DNA viruses such as human adenoviruses (HAdVs) causes a high-level accumulation of viral DNA and mRNA in the cell population. However, the average viral DNA and mRNA content in a heterogeneous cell population does not inevitabl...
Robert T Todd,Ann L Braverman,Anna Selmecki
Robert T Todd
Ploidy, the number of sets of homologous chromosomes in a cell, can alter cellular physiology, gene regulation, and the spectrum of acquired mutations. Advances in single-cell flow cytometry have greatly improved the understanding of how ge...
Kwang-Woo Jung,Kyung-Tae Lee,Yee-Seul So et al.
Kwang-Woo Jung et al.
Cryptococcus neoformans is an opportunistic fungal pathogen, which causes life-threatening meningoencephalitis in immunocompromised individuals and is responsible for more than 1,000,000 infections and 600,000 deaths annually worldwide. Nev...
Megha Gulati,Matthew B Lohse,Craig L Ennis et al.
Megha Gulati et al.
Candida albicans is a normal member of the human microbiota that asymptomatically colonizes healthy individuals, however it is also an opportunistic pathogen that can cause severe infections, especially in immunocompromised individuals. The...
Benjamin J Koestler,Cara M Ward,Shelley M Payne
Benjamin J Koestler
Shigella is an enteroinvasive human pathogen that infects the colonic epithelium and causes Shigellosis, an infectious diarrheal disease. There is no vaccine for the prevention or treatment of Shigellosis and antibiotic-resistant strains of...
Savannah E Sanchez,Eduardo Vallejo-Esquerra,Anders Omsland
Savannah E Sanchez
Coxiella burnetii is a highly infectious obligate intracellular bacterium and the etiological agent of the zoonosis Query (Q) fever. This Gram-negative gamma-proteobacterium has adapted to replicate within a specialized compartment in mamma...