Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes [0.03%]
不同亚型乳腺癌转基因小鼠模型的研究进展概述
Jerry Usary,David Brian Darr,Adam D Pfefferle et al.
Jerry Usary et al.
Advances in the screening of new therapeutic options have significantly reduced the breast cancer death rate over the last decade. Despite these advances, breast cancer remains the second leading cause of cancer death among women. This is d...
Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery [0.03%]
转基因胶质母细胞瘤和寡形星形细胞CNS模型及其在药物发现中的应用概述
Fuyi Chen,Albert Becker,Joseph LoTurco
Fuyi Chen
Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero ...
Norio Yamamoto,Manabu Ueda-Wakagi,Takuya Sato et al.
Norio Yamamoto et al.
Facilitative glucose uptake transport systems are ubiquitous in animal cells and are responsible for transporting glucose across cell surface membranes. Evaluation of glucose uptake is crucial in the study of numerous diseases and metabolic...
A Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte (hiPSC-CM) Multielectrode Array Assay for Preclinical Cardiac Electrophysiology Safety Screening [0.03%]
一种临床前心脏电生理安全性筛选的人诱导多能干细胞源性心肌细胞多电极阵列测定法
Kate Harris
Kate Harris
Cardiotoxicity is a leading cause of compound attrition during drug development. Preclinical models used to assess the risk for compound-induced effects on cardiac electrophysiology largely rely on animals that can differ in terms of sensit...
Arnaud Dupuis,Véronique Heim,Philippe Ohlmann et al.
Arnaud Dupuis et al.
The P2Y₁₂/ADP receptor plays a central role in platelet activation. Characterization of this receptor is mandatory for studying disorders associated with a P2Y₁₂ receptor defect and for evaluating P2Y₁₂ receptor agonists and antagonis...
Sigma Receptor Binding Assays [0.03%]
σ受体结合试验
Uyen B Chu,Arnold E Ruoho
Uyen B Chu
Sigma receptors, both Sigma-1(S1R) and Sigma-2 (S2R), are small molecule-regulated, primarily endoplasmic reticulum (ER) membrane-associated sites. A number of drugs bind to sigma receptors, including the antipsychotic haloperidol and (+)-p...
Thomas Philips,Jeffrey D Rothstein
Thomas Philips
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and lower motor neurons in the central nervous system. Patients with ALS develop extensive muscle wasting and atrophy leading to paralysis and death 3 to 5 years ...
Determination of GPCR Phosphorylation Status: Establishing a Phosphorylation Barcode [0.03%]
GPCR磷酸化状态的确定：建立磷酸化条形码
Rudi Prihandoko,Sophie J Bradley,Andrew B Tobin et al.
Rudi Prihandoko et al.
G protein-coupled receptors (GPCRs) are rapidly phosphorylated following agonist occupation in a process that mediates receptor uncoupling from its cognate G protein, a process referred to as desensitization. In addition, this process provi...
Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer [0.03%]
Helicobacter（pyloro或felis）相关胃癌的小鼠模型
Carrie A Duckworth,Michael D Burkitt,Jonathan M Williams et al.
Carrie A Duckworth et al.
Gastric adenocarcinoma is the fifth most common cancer and third most common cause of cancer-related death in the world. The majority of these cancers develop in genetically susceptible individuals who are chronically infected with the Gram...
Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement [0.03%]
转基因小鼠模型在乳头状和未分化甲状腺癌研究中的进展及转化医学意义
Roch-Philippe Charles
Roch-Philippe Charles
The prognosis from thyroid cancer subtypes in humans covers a spectrum from "cured at almost 90%" to "100% lethal." Invasive and poorly differentiated forms of thyroid cancer are among the most aggressive human cancers, and there are few ef...