Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue [0.03%]
人多能干细胞来源的心内胚层分化心肌细胞和内皮细胞的共分化为心脏微组织提供三维模型
Elisa Giacomelli,Milena Bellin,Valeria V Orlova et al.
Elisa Giacomelli et al.
The formation of cardiac mesodermal subtypes is highly regulated in time and space during heart development. In vitro models based on human pluripotent stem cells (hPS cells) provide opportunities to study mechanisms underlying fate choices...
Matchmaker Exchange [0.03%]
匹配平台交换
Nara L M Sobreira,Harindra Arachchi,Orion J Buske et al.
Nara L M Sobreira et al.
In well over half of the individuals with rare disease who undergo clinical or research next-generation sequencing, the responsible gene cannot be determined. Some reasons for this relatively low yield include unappreciated phenotypic heter...
Daniel Shriner
Daniel Shriner
Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to Americans who trace ancestry to various combinations of Native Americans...
Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer (HNPCC) [0.03%]
遗传学检验在遗传性非息肉病性大肠癌中的应用(HNPCC)
Babi Ramesh Reddy Nallamilli,Madhuri Hegde
Babi Ramesh Reddy Nallamilli
Hereditary nonpolyposis colorectal cancer (HNPCC), also called Lynch syndrome, is an autosomal dominant cancer syndrome that confers an elevated risk of early-onset colorectal cancer (CRC) and increased lifetime risk for other cancers of th...
Katy Phelan,Kristin M May
Katy Phelan
Cultured mammalian cells are used extensively in the field of human genetics. It requires a number of special skills in order to be able to preserve the structure, function, behavior, and biology of the cells in culture. This unit describes...
George McNamara,Michael Difilippantonio,Thomas Ried et al.
George McNamara et al.
This unit provides an overview of light microscopy, including objectives, light sources, filters, film, and color photography for fluorescence microscopy and fluorescence in situ hybridization (FISH). We believe there are excellent opportun...
Sara Goodwin,Robert Wappel,W Richard McCombie
Sara Goodwin
Today's short-read sequencing instruments can generate read lengths between 50 bp and 700 bp depending on the specific instrument. These high-throughput sequencing approaches have revolutionized genomic science, allowing hundreds of thousan...
Zirui Dong,Weiwei Xie,Haixiao Chen et al.
Zirui Dong et al.
Emerging studies have demonstrated that whole-genome sequencing (WGS) is an efficient tool for copy-number variants (CNV) detection, particularly in probe-poor regions, as compared to chromosomal microarray analysis (CMA). However, the cost...
Computational Approach to Measuring Myocyte Disarray in Animal Models of Heart Disease [0.03%]
计算方法在心脏疾病动物模型心肌细胞排列测量中的应用
William Wan,Leslie Leinwand
William Wan
In cardiovascular disease research, studies often include measuring cardiac function and performing histological examination of heart tissue. After measuring contractility, hearts from animals such as mice and rats are often frozen or fixed...
Bruce R Korf,Fady M Mikhail
Bruce R Korf
Both cytogenetic and molecular genetic studies can contribute to the management of patients with cancer. In some cases, genetic markers are specific to particular tumor types and are useful in diagnosis. This can be helpful in distinguishin...